Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christopher P Ptak"'
Autor:
Ching-Lin Hsieh, Christopher P Ptak, Andrew Tseng, Igor Massahiro de Souza Suguiura, Sean P McDonough, Tepyuda Sritrakul, Ting Li, Yi-Pin Lin, Richard E Gillilan, Robert E Oswald, Yung-Fu Chang
Publikováno v:
eLife, Vol 6 (2017)
Pathogens rely on proteins embedded on their surface to perform tasks essential for host infection. These obligatory structures exposed to the host immune system provide important targets for rational vaccine design. Here, we use a systematically des
Externí odkaz:
https://doaj.org/article/a50dc2ca412046858cd4e180b079cee2
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/dbe10c24123c4c7c86aaba67ed53b5ee
Autor:
Wen-Chin Lin, Christopher P. Ptak, Chi-Yu Chang, Man-Kei Ian, Min-Yuan Chia, Ter-Hsin Chen, Chih-Jung Kuo
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Bovine enteric bacterial pathogens are a major cause of health decline in agricultural cattle populations. The identification of host-derived microbiota with probiotic characteristics is key for the development of treatments utilizing pathogen displa
Externí odkaz:
https://doaj.org/article/aad8e8c53ba641778bbf024f046dc93e
Autor:
Christopher P. Ptak, Tabitha A. Peterson, Jesse B. Hopkins, Christopher A. Ahern, Michael E. Shy, Robert C. Piper
Mutations in Myelin Protein Zero (MPZ) account for 5% of Charcot-Marie-Tooth cases and can cause demyelinating or axonal phenotypes, reflecting the diverse roles of MPZ in Schwann cells. MPZ holds the apposing membranes of the myelin sheath together,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52ea1c55e4a10e4fdf90d568145b698
https://doi.org/10.1101/2023.03.18.533291
https://doi.org/10.1101/2023.03.18.533291
Autor:
Ryan K. Betters, Emma Luhmann, Amy C. Gottschalk, Zhen Xu, Christopher P. Ptak, Kimberly L. Fiock, Lilliana C. Radoshevich, Marco M. Hefti
Tau phosphorylation and aggregation is the final common pathway for neuronal toxicity across multiple neurodegenerative diseases including Alzheimer disease, progressive supranuclear palsy, and corticobasal degeneration. We have previously shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86578f6286d292baaff46a8da5b1730e
https://doi.org/10.1101/2022.10.17.512532
https://doi.org/10.1101/2022.10.17.512532
Autor:
Tiffany S. Dwyer, Joseph B. O’Brien, Christopher P. Ptak, Justin E. LaVigne, Daniel P. Flaherty, Val J. Watts, David L. Roman
Publikováno v:
Purdue University Libraries Open Access Publishing Support Fund
Genetic and preclinical studies have implicated adenylyl cyclase 1 (AC1) as a potential target for the treatment of chronic inflammatory pain. AC1 activity is increased following inflammatory pain stimuli and AC1 knockout mice show a marked reduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228f36c4db23e8760fe01a31099b0779
https://docs.lib.purdue.edu/cgi/viewcontent.cgi?article=1042&context=fund
https://docs.lib.purdue.edu/cgi/viewcontent.cgi?article=1042&context=fund
Autor:
Ryan K. Betters, Emma Luhmann, Amy C. Gottschalk, Zhen Xu, Mallory R. Shin, Christopher P. Ptak, Kimberly L. Fiock, Lilliana C. Radoshevich, Marco M. Hefti
Publikováno v:
eneuro. 10:ENEURO.0503-22.2023
Despite exhibiting tau phosphorylation similar to Alzheimer’s disease (AD), the human fetal brain is remarkably resilient to tau aggregation and toxicity. To identify potential mechanisms for this resilience, we used co-immunoprecipitation (co-IP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4ff719116cd77dbbe2eb664c8a9409b
https://doi.org/10.1523/eneuro.0503-22.2023
https://doi.org/10.1523/eneuro.0503-22.2023
Autor:
Matthew T. Sipple, Christine Yuan, Robert E. Oswald, Edward Y. Shi, Jayasri Srinivasan, Linda M. Nowak, Christopher P. Ptak
Publikováno v:
The Journal of General Physiology
Glutamate activates individual subunits of AMPA receptors in a stepwise manner. Shi et al. reveal that two noncompetitive antagonists disrupt this gating pattern and that their binding sites at the boundary between the transmembrane and extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7cfa02b593884c550685633c7432a82
https://doi.org/10.1085/jgp.201812209
https://doi.org/10.1085/jgp.201812209
Autor:
Ping He, Mohd Akif, Yinghua Xu, Christopher P. Ptak, Robert E. Oswald, Alex Devarajan, Yung-Fu Chang, Ching-Lin Hsieh
Publikováno v:
Biotechnology and Bioengineering. 116:260-271
Recombinant antigens exhibit targeted protectiveproperties and offer important opportunities in the development of therapeutic technologies. Biophysical and structural methods have become important tools for the rational design and engineering of imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54be5bfba54caf25a4393f2778d16b1f
https://doi.org/10.1002/bit.26864
https://doi.org/10.1002/bit.26864
Autor:
Ter-Hsin Chen, Chi-Yu Chang, Min-Yuan Chia, Man-Kei Ian, Chih-Jung Kuo, Christopher P. Ptak, Wen-Chin Lin
Publikováno v:
Frontiers in Veterinary Science
Frontiers in Veterinary Science, Vol 7 (2020)
Frontiers in Veterinary Science, Vol 7 (2020)
Bovine enteric bacterial pathogens are a major cause of health decline in agricultural cattle populations. The identification of host-derived microbiota with probiotic characteristics is key for the development of treatments utilizing pathogen displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d51d3d2aa8d2ed8408feaa619172594