Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher P Ilch"'
Autor:
Bryan D. Moyer, Brad Herberich, Kaustav Biswas, Kenneth W. Walker, Beth D. Youngblood, Jennifer Aral, Tayo Ikotun, Min-Hwa Jasmine Lin, Linh Tran, Thomas Kornecook, Hongyan Li, Thomas Nixey, Joseph Ligutti, Shanti Amagasu, Li Yin, Xuhai Be, Kristin L. Andrews, Christopher M. Tegley, Charles Glaus, Marcus Soto, Les P. Miranda, James R. Falsey, Jason Long, Yuan Cheng, Robert S. Foti, Hossein Salimi-Moosavi, Kelvin Sham, Christopher P Ilch, Bin Wu, Justin K. Murray, Margaret Karow, Chawita Netirojjanakul, Liz Doherty
Publikováno v:
ACS Chemical Biology. 14:806-818
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel NaV1.7, is being pursued to address the unmet medical need with respect to chronic pain and the rising opioid epidemic. As part of e
Autor:
Bin Wu, Shanti Amagasu, Jason Long, Justin K. Murray, Kristin L. Andrews, Jennifer Aral, Les P. Miranda, Xuhai Be, Kaustav Biswas, Min-Hwa Jasmine Lin, Dong Liu, Zhulun Wang, Anruo Zou, Bryan D. Moyer, Joseph Ligutti, Xiaoshan Min, Kelvin Sham, Thomas Kornecook, Christopher P Ilch
Publikováno v:
Journal of Medicinal Chemistry. 61:9500-9512
Inhibitors of the voltage-gated sodium channel NaV1.7 are being investigated as pain therapeutics due to compelling human genetics. We previously identified NaV1.7-inhibitory peptides GpTx-1 and JzTx-V from tarantula venom screens. Potency and select
Autor:
Stefan I. McDonough, Min-Hwa Jasmine Lin, Erin F. DiMauro, Violeta Yu, Angel Guzman-Perez, Kristin Taborn, Christiane Bode, Thomas Kornecook, Thomas Dineen, Xin Huang, Robert T. Fremeau, Margaret Chu-Moyer, James R. Coats, Bingfan Du, Jeff S. McDermott, Hakan Gunaydin, Daniel S. La, Hua Gao, Bryan D. Moyer, Russell Graceffa, Alessandro Boezio, Charles Kreiman, Matthew Weiss, Hanh Nho Nguyen, David J. Matson, Joseph Ligutti, Christopher P Ilch, Isaac E. Marx, Emily A. Peterson, Howard Bregman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3477-3485
The voltage-gated sodium channel NaV1.7 has received much attention from the scientific community due to compelling human genetic data linking gain- and loss-of-function mutations to pain phenotypes. Despite this genetic validation of NaV1.7 as a tar
Autor:
Kristin Taborn, Joseph Ligutti, Josie H. Lee, Thomas Kornecook, Dong Liu, Dawn Zhu, Stephen Altmann, Ruoyuan Yin, Xuhai Be, Robert T. Fremeau, Jinti Wang, John Roberts, David J. Matson, Danielle Johnson, Violeta Yu, Christopher P Ilch, Bryan D. Moyer, Jason A. Luther, Virginia Berry, Matthew Weiss, Danny Ortuno, Michael Jarosh, Sonya G. Lehto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:146-160
Potent and selective antagonists of the voltage-gated sodium channel NaV1.7 represent a promising avenue for the development of new chronic pain therapies. We generated a small molecule atropisomer quinolone sulfonamide antagonist AMG8379 and a less
Autor:
Jessica Able, Benjamin C. Milgram, Loren Berry, Melanie Cooke, Liyue Huang, John Butler, Hongbing Huang, Violeta Yu, Kristin Taborn, John D. Roberts, Steven Altmann, Margaret Y. Chu-Moyer, John Yeoman, Jean Wang, Roman Shimanovich, Russell Graceffa, Matthew Weiss, Thomas Kornecook, Christopher P Ilch, Bryan D. Moyer, Christiane Boezio, Isaac E. Marx, Brian A. Sparling, Emily A. Peterson, Gwen Rescourio, Charles Kreiman, Elma Feric Bojic, Karina R. Vaida, Angel Guzman-Perez, Dawn Zhu, Hua Gao, Laurie B. Schenkel, Michael Jarosh, Hanh Nho Nguyen, Joseph Ligutti, Alessandro Boezio, Hakan Gunaydin, Daniel S. La, Thomas Dineen, Robert T. Fremeau, Robert S. Foti, Min-Hwa Jasmine Lin, Erin F. DiMauro, John Stellwagen
Publikováno v:
Journal of Medicinal Chemistry. 60:5990-6017
Because of its strong genetic validation, NaV1.7 has attracted significant interest as a target for the treatment of pain. We have previously reported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors that demo
Autor:
Justin K, Murray, Bin, Wu, Christopher M, Tegley, Thomas E, Nixey, James R, Falsey, Brad, Herberich, Li, Yin, Kelvin, Sham, Jason, Long, Jennifer, Aral, Yuan, Cheng, Chawita, Netirojjanakul, Liz, Doherty, Charles, Glaus, Tayo, Ikotun, Hongyan, Li, Linh, Tran, Marcus, Soto, Hossein, Salimi-Moosavi, Joseph, Ligutti, Shanti, Amagasu, Kristin L, Andrews, Xuhai, Be, Min-Hwa Jasmine, Lin, Robert S, Foti, Christopher P, Ilch, Beth, Youngblood, Thomas J, Kornecook, Margaret, Karow, Kenneth W, Walker, Bryan D, Moyer, Kaustav, Biswas, Les P, Miranda
Publikováno v:
ACS chemical biology. 14(4)
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel Na
Autor:
Bin, Wu, Justin K, Murray, Kristin L, Andrews, Kelvin, Sham, Jason, Long, Jennifer, Aral, Joseph, Ligutti, Shanti, Amagasu, Dong, Liu, Anruo, Zou, Xiaoshan, Min, Zhulun, Wang, Christopher P, Ilch, Thomas J, Kornecook, Min-Hwa Jasmine, Lin, Xuhai, Be, Les P, Miranda, Bryan D, Moyer, Kaustav, Biswas
Publikováno v:
Journal of medicinal chemistry. 61(21)
Inhibitors of the voltage-gated sodium channel Na
Autor:
Christopher P Ilch, Eugene V. Golanov
Publikováno v:
Neuroscience Letters. 368:92-95
In Sprague-Dawley rats symmetrical sites of the parietal cortex were microinjected with ibotenic acid (IBO, 10microg in 1microl) to lesion local neurons or with saline (1microl). Five days later, changes of cortical cerebral blood flow (CBF) in respo
Publikováno v:
Brain research. 994(2)
We investigated whether selective stimulation of neurons of the sympathoinhibitory ventral periaqueductal gray (VPAG), or sympathoexcitatory dorsal periaqueductal gray (DPAG), differentially modulates CBF and EEG and exerts neuroprotection. Electrica
Publikováno v:
Brain research. 912(1)
We investigated whether stimulation of the functionally discrete subthalamic region, subthalamic cerebrovasodilator area (SVA), which increases cerebral blood flow (CBF) when excited, would, like stimulation of cerebellar fastigial nucleus (FN), prod