Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Christopher P Arthur"'
Autor:
Marc Kschonsak, Christine C Jao, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Publikováno v:
eLife, Vol 12 (2023)
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel analgesic target due to its involvement in human pain syndromes. However, clinically available NaV channel-blocking drugs are not selective among the nine NaV chan
Externí odkaz:
https://doaj.org/article/1b1793fee7d349608601029e46d0c8cd
Autor:
Sigrid Noreng, Naruhisa Ota, Yonglian Sun, Hoangdung Ho, Matthew Johnson, Christopher P. Arthur, Kellen Schneider, Isabelle Lehoux, Christopher W. Davies, Kyle Mortara, Kit Wong, Dhaya Seshasayee, Matthieu Masureel, Jian Payandeh, Tangsheng Yi, James T. Koerber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
NADPH oxidase NOX2 produces superoxide, a reactive oxygen species essential in innate immunity. Here, the authors reveal the structure of the NOX2 core, rationalize disease-causing mutations, and suggest avenues for selective NOX2 pharmacological mod
Externí odkaz:
https://doaj.org/article/d13cff7b590548a384f3e3bb6a259cd4
Autor:
Cameron L. Noland, Han Chow Chua, Marc Kschonsak, Stephanie Andrea Heusser, Nina Braun, Timothy Chang, Christine Tam, Jia Tang, Christopher P. Arthur, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
NaX is an atypical member of the voltage-gated sodium channel family that may contribute to Na+ homeostasis. Here, the authors describe the structural and functional attributes of the human NaX channel to reveal new insights into its physiology.
Externí odkaz:
https://doaj.org/article/2f977168e29d4738843b01d6e6b08fea
Autor:
Michael J. Holliday, Axel Witt, Alejandro Rodríguez Gama, Benjamin T. Walters, Christopher P. Arthur, Randal Halfmann, Alexis Rohou, Erin C. Dueber, Wayne J. Fairbrother
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the struct
Externí odkaz:
https://doaj.org/article/7e23aebac6c444bc92a15b78399d9b56
Autor:
Christine C Jao, Marc Kschonsak, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd282fdd94d6f54f454fbf1d90a6ee32
https://doi.org/10.7554/elife.84151.sa2
https://doi.org/10.7554/elife.84151.sa2
Autor:
Marc Kschonsak, Christine C. Jao, Christopher P. Arthur, Alexis L. Rohou, Philippe Bergeron, Daniel Ortwine, Steven J. McKerrall, David H. Hackos, Lunbin Deng, Jun Chen, Peter S. Dragovich, Matthew Volgraf, Matthew R. Wright, Jian Payandeh, Claudio Ciferri, John C. Tellis
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel pain target due to its striking human genetics. However, clinically available drugs (e.g. lidocaine, carbamazepine, etc.) are not selective among the nine NaV chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb81783c5e491a22f8ca88176067e13
https://doi.org/10.1101/2022.11.10.515983
https://doi.org/10.1101/2022.11.10.515983
Autor:
Christopher J. Arthur
Publikováno v:
Revista Opinião Filosófica, Vol 7, Iss 1 (2017)
Externí odkaz:
https://doaj.org/article/fbec55c8d17a487ab35258517903a42c
Autor:
Radosław Chaber, Artur Gurgul, Grażyna Wróbel, Olga Haus, Anna Tomoń, Jerzy Kowalczyk, Tomasz Szmatoła, Igor Jasielczuk, Blanka Rybka, Renata Ryczan-Krawczyk, Ewa Duszeńko, Sylwia Stąpor, Krzysztof Ciebiera, Sylwia Paszek, Natalia Potocka, Christopher J Arthur, Izabela Zawlik
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187422 (2017)
In addition to genetic alterations, epigenetic abnormalities have been shown to underlie the pathogenesis of acute lymphoblastic leukemia (ALL)-the most common pediatric cancer. The purpose of this study was to characterize the whole genome DNA methy
Externí odkaz:
https://doaj.org/article/2ebb20b6e6f24b5b88b8aa6760e5670d
Autor:
Radosław Chaber, Christopher J. Arthur, Kornelia Łach, Anna Raciborska, Elżbieta Michalak, Katarzyna Bilska, Katarzyna Drabko, Joanna Depciuch, Ewa Kaznowska, Józef Cebulski
Publikováno v:
Molecules, Vol 24, Iss 6, p 1075 (2019)
Background: Improved outcome prediction is vital for the delivery of risk-adjusted, appropriate and effective care to paediatric patients with Ewing sarcoma—the second most common paediatric malignant bone tumour. Fourier transform infrared (FTIR)
Externí odkaz:
https://doaj.org/article/f3bfc9d9fa3c4472a744b61c5f9ca0fe
Autor:
Marc Kschonsak, Matthew C. Johnson, Rachel Schelling, Evan M. Green, Lionel Rougé, Hoangdung Ho, Nidhi Patel, Cem Kilic, Edward Kraft, Christopher P. Arthur, Alexis L. Rohou, Laetitia Comps-Agrar, Nadia Martinez-Martin, Laurent Perez, Jian Payandeh, Claudio Ciferri
Publikováno v:
Science advances, vol. 8, no. 10, pp. eabm2536
Human cytomegalovirus (HCMV) represents the viral leading cause of congenital birth defects and uses the gH/gL/UL128-130-131A complex (Pentamer) to enter different cell types, including epithelial and endothelial cells. Upon infection, Pentamer elici