Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Christopher P, Wardell"'
Autor:
William J. Shelton, Sara Zandpazandi, J Stephen Nix, Murat Gokden, Michael Bauer, Katie Rose Ryan, Christopher P. Wardell, Olena Morozova Vaske, Analiz Rodriguez
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Brain tumors and genomics have a long-standing history given that glioblastoma was the first cancer studied by the cancer genome atlas. The numerous and continuous advances through the decades in sequencing technologies have aided in the advanced mol
Externí odkaz:
https://doaj.org/article/6ee3c7254d974a7db2c250c9dd959af6
Autor:
Cody Ashby, Eileen M. Boyle, Michael A. Bauer, Aneta Mikulasova, Christopher P. Wardell, Louis Williams, Ariel Siegel, Patrick Blaney, Marc Braunstein, David Kaminetsky, Jonathan Keats, Francesco Maura, Ola Landgren, Brian A. Walker, Faith E. Davies, Gareth J. Morgan
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 5, Pp 1-9 (2022)
Abstract Deciphering genomic architecture is key to identifying novel disease drivers and understanding the mechanisms underlying myeloma initiation and progression. In this work, using the CoMMpass dataset, we show that structural variants (SV) occu
Externí odkaz:
https://doaj.org/article/bfe0c5a7378449fc9275731e9baa6d54
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-6 (2021)
Abstract Background Somatic variant callers are used to find mutations in sequencing data from cancer samples. They are very sensitive and have high recall, but also may produce low precision data with a large proportion of false positives. Further a
Externí odkaz:
https://doaj.org/article/54d6ebbc829b4647a51fb4529e0b44ca
Autor:
Eileen M. Boyle, Shayu Deshpande, Ruslana Tytarenko, Cody Ashby, Yan Wang, Michael A. Bauer, Sarah K. Johnson, Christopher P. Wardell, Sharmilan Thanendrarajan, Maurizio Zangari, Thierry Facon, Charles Dumontet, Bart Barlogie, Arnaldo Arbini, Even H. Rustad, Francesco Maura, Ola Landgren, Fenghuang Zhan, Frits van Rhee, Carolina Schinke, Faith E. Davies, Gareth J. Morgan, Brian A. Walker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Progression from asymptomatic smoldering multiple myeloma (SMM) to symptomatic Multiple Myeloma occurs at different rates in different patients. Here, the authors report fewer NRAS and FAM46C mutations and adverse translocations in SMM compared to MM
Externí odkaz:
https://doaj.org/article/190cc8a591d94b4a813749741597a52e
Autor:
Erin M. Taylor, Stephanie D. Byrum, Jacob L. Edmondson, Christopher P. Wardell, Brittany G. Griffin, Sara C. Shalin, Murat Gokden, Issam Makhoul, Alan J. Tackett, Analiz Rodriguez
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-9 (2020)
Abstract Melanoma brain metastases (MBM) portend a grim prognosis and can occur in up to 40% of melanoma patients. Genomic characterization of brain metastases has been previously carried out to identify potential mutational drivers. However, to date
Externí odkaz:
https://doaj.org/article/2a33993e84a6480b9d4e9f4e173ccc47
Autor:
Cody Ashby, Michael Rutherford, Michael A. Bauer, Erich A. Peterson, Yan Wang, Eileen M. Boyle, Christopher P. Wardell, Brian A. Walker
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background The study of cancer genomics continually matures as the number of patient samples sequenced increases. As more data is generated, oncogenic drivers for specific cancer types are discovered along with their associated risks. This i
Externí odkaz:
https://doaj.org/article/fc9f9a214b9e440f9abe6c0ab4b3f1a4
Autor:
Megan R. Reed, A. Geoffrey Lyle, Annick De Loose, Katrina Learned, Cecile Rose T. Vibat, Christopher P. Wardell, Robert L. Eoff, Olena M. Vaske, Analiz Rodriguez
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 58-58 (2022)
OBJECTIVES/GOALS: A functional precision medicine platform to identify therapeutic targets for a glioblastoma patient with Li Fraumeni syndrome was performed. Comparative transcriptomics identified druggable targets and patient derived organoids and
Externí odkaz:
https://doaj.org/article/c2c3317ab6de45a186e45d9014a1a342
Autor:
Aneta Mikulasova, Cody Ashby, Ruslana G. Tytarenko, Pingping Qu, Adam Rosenthal, Judith A. Dent, Katie R. Ryan, Michael A. Bauer, Christopher P. Wardell, Antje Hoering, Konstantinos Mavrommatis, Matthew Trotter, Shayu Deshpande, Shmuel Yaccoby, Erming Tian, Jonathan Keats, Daniel Auclair, Graham H. Jackson, Faith E. Davies, Anjan Thakurta, Gareth J. Morgan, Brian A. Walker
Publikováno v:
Haematologica, Vol 105, Iss 4 (2020)
MYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation are poorly understood. We sho
Externí odkaz:
https://doaj.org/article/5a3d144402e64ba28314204a68ef38ea
Autor:
Megan R. Reed, A. Geoffrey Lyle, Annick De Loose, Leena Maddukuri, Katrina Learned, Holly C. Beale, Ellen T. Kephart, Allison Cheney, Anouk van den Bout, Madison P. Lee, Kelsey N. Hundley, Ashley M. Smith, Teresa M. DesRochers, Cecile Rose T. Vibat, Murat Gokden, Sofie Salama, Christopher P. Wardell, Robert L. Eoff, Olena M. Vaske, Analiz Rodriguez
Publikováno v:
Cells, Vol 10, Iss 12, p 3400 (2021)
Li Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by germline mutations in TP53. TP53 is the most common mutated gene in human cancer, occurring in 30–50% of glioblastomas (GBM). Here, we highlight a precision medicin
Externí odkaz:
https://doaj.org/article/9dc85f09d7834fddbaa84d2a1a8e9843
Autor:
Christopher P. Wardell, Emilie Darrigues, Annick De Loose, Madison P. Lee, Murat Gokden, Issam Makhoul, Alan J. Tackett, Analiz Rodriguez
Publikováno v:
Cancers, Vol 13, Iss 22, p 5598 (2021)
Brain metastases (BM) are the most common brain tumors in adults occurring in up to 40% of all cancer patients. Multi-omics approaches allow for understanding molecular mechanisms and identification of markers with prognostic significance. In this st
Externí odkaz:
https://doaj.org/article/d591e78b2b614af4abc722ff1c15d4d9