Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Christopher P, Calderon"'
Publikováno v:
Biotechnology and Bioengineering. 119:3596-3611
Processing stresses on therapeutic proteins may cause formation of subvisible particles. Different stress mechanisms generate particle populations with characteristic morphological "fingerprints," and machine learning techniques like convolutional ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23474a87f136ff097e4c212ab76447b2
https://doi.org/10.1002/bit.28239
https://doi.org/10.1002/bit.28239
Autor:
Nidhi G. Thite, Saba Ghazvini, Nicole Wallace, Naomi Feldman, Christopher P. Calderon, Theodore W. Randolph
Publikováno v:
Journal of Pharmaceutical Sciences. 111:2730-2744
Container choice can influence particle generation within protein formulations. Incompatibility between proteins and containers can manifest as increased particle concentrations, shifts in particle size distributions and changes in particle morpholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a550ab80e406b89caa9e8b42352a4696
https://doi.org/10.1016/j.xphs.2022.06.017
https://doi.org/10.1016/j.xphs.2022.06.017
Autor:
Christopher P. Calderon, Dean C. Ripple, Charudharshini Srinivasan, Youlong Ma, Michael J. Carrier, Theodore W. Randolph, Thomas F. O’Connor
Publikováno v:
Pharmaceutical Research. 39:263-279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eaa8f32c74e6fb7f90ba5d3c22fb8cf
https://doi.org/10.1007/s11095-021-03130-9
https://doi.org/10.1007/s11095-021-03130-9
Autor:
Christopher J. Obara, Jonathon Nixon-Abell, Andrew S. Moore, Federica Riccio, David P. Hoffman, Gleb Shtengel, C. Shan Xu, Kathy Schaefer, H. Amalia Pasolli, Jean-Baptiste Masson, Harald F. Hess, Christopher P. Calderon, Craig Blackstone, Jennifer Lippincott-Schwartz
To coordinate cellular physiology, eukaryotic cells rely on the inter-organelle transfer of molecules at specialized organelle-organelle contact sites1,2. Endoplasmic reticulum-mitochondria contact sites (ERMCSs) are particularly vital communication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579fc9145c33d990b7a7a084005a5ccb
https://doi.org/10.1101/2022.09.03.505525
https://doi.org/10.1101/2022.09.03.505525
Autor:
Theodore W. Randolph, Alyssa E. Witeof, Andrew P. Goodwin, Christopher P. Calderon, Austin L. Daniels, Sanli Movafaghi, Mary D. Kelly
Publikováno v:
ACS Applied Bio Materials. 4:6946-6953
This work reports the ability of hydrogel coatings to protect therapeutic proteins from cavitation-induced aggregation caused by mechanical stress. Here, we show that polyacrylamide hydrogel coatings on container surfaces suppress mechanical shock-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c8ed65728bbac029fed3ce14104a75
https://doi.org/10.1021/acsabm.1c00622
https://doi.org/10.1021/acsabm.1c00622
Autor:
Christopher P. Calderon
Publikováno v:
Molecules, Vol 19, Iss 11, Pp 18381-18398 (2014)
Optical microscopes and nanoscale probes (AFM, optical tweezers, etc.) afford researchers tools capable of quantitatively exploring how molecules interact with one another in live cells. The analysis of in vivo single-molecule experimental data faces
Externí odkaz:
https://doaj.org/article/a0d77cbe27254896a9980b2426edc329
Autor:
Christopher P. Calderon
Publikováno v:
Molecules, Vol 20, Iss 2, Pp 2828-2830 (2015)
The author wishes to make the following corrections to paper [1] (doi:10.3390/molecules191118381, website: http://www.mdpi.com/1420-3049/19/11/18381):
Externí odkaz:
https://doaj.org/article/c1759f1c53ac44f589ebd899b1fc3a40
Publikováno v:
Journal of pharmaceutical sciences. 111(9)
This study investigates how backgrounded membrane imaging (BMI) can be used in combination with convolutional neural networks (CNNs) in order to quantitatively and qualitatively study subvisible particles in both protein biopharmaceuticals and sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c93597c3a581a933345882dfe66c4ff
https://pubmed.ncbi.nlm.nih.gov/35661758
https://pubmed.ncbi.nlm.nih.gov/35661758
Publikováno v:
The Journal of Physical Chemistry B. 124:8110-8123
Appropriate time series modeling of complex diffusion in soft matter systems on the microsecond time scale can provide a path toward inferring transport mechanisms and predicting bulk properties characteristic of much longer time scales. In this work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65ad338af032a71960fd2d55e635b69
https://doi.org/10.1021/acs.jpcb.0c05010
https://doi.org/10.1021/acs.jpcb.0c05010
Publikováno v:
Biotechnol Bioeng
Therapeutic proteins are exposed to numerous stresses during their manufacture, shipping, storage and administration to patients, causing them to aggregate and form particles through a variety of different mechanisms. These varied mechanisms generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b71a8d8725e3558d8a5ed2a0de9936f
https://doi.org/10.1002/bit.27501
https://doi.org/10.1002/bit.27501