Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Christopher O. Miles"'
Autor:
Christopher O. Miles, Pearse McCarron, Krista Thomas, Bakir Al-Sinawi, Tianzhe Liu, Brett A. Neilan
Publikováno v:
ACS Omega, Vol 9, Iss 25, Pp 27618-27631 (2024)
Externí odkaz:
https://doaj.org/article/b565c7ca4bbb445e881d7e79da0bb6c1
Autor:
Fedor Kryuchkov, Alison Robertson, Elizabeth M. Mudge, Christopher O. Miles, Soetkien Van Gothem, Silvio Uhlig
Publikováno v:
Toxins, Vol 14, Iss 6, p 399 (2022)
Ciguatera poisoning is a global health concern caused by the consumption of seafood containing ciguatoxins (CTXs). Detection of CTXs poses significant analytical challenges due to their low abundance even in highly toxic fish, the diverse and in-part
Externí odkaz:
https://doaj.org/article/3338470bda374c99996ec049a6112ad4
Publikováno v:
Toxicon: X, Vol 8, Iss , Pp 100059- (2020)
Azaspiracids (AZAs) are lipophilic polyether toxins produced by Azadinium and Amphidoma species of marine microalgae. The main dinoflagellate precursors AZA1 and AZA2 are metabolized by shellfish to produce an array of AZA analogues. Many marine toxi
Externí odkaz:
https://doaj.org/article/986e71f36b154718ba3218b51daef79e
Publikováno v:
Toxicon: X, Vol 6, Iss , Pp - (2020)
We have investigated the in vitro metabolism of pectenotoxin-2 (PTX-2) using primary hepatocytes from Wistar rats in suspension. Purified PTX-2 was rapidly metabolized. Two major and several minor oxidized PTX-2 metabolites were formed, none of which
Externí odkaz:
https://doaj.org/article/cf3a966a7a3d43f7abb3ad8c53d9a07d
Autor:
Alistair L. Wilkins, Thomas Rundberget, Morten Sandvik, Frode Rise, Brent K. Knudsen, Jane Kilcoyne, Beatriz Reguera, Pilar Rial, Elliott J. Wright, Sabrina D. Giddings, Michael J. Boundy, Cheryl Rafuse, Christopher O. Miles
Publikováno v:
Toxins, Vol 13, Iss 8, p 510 (2021)
Two high-mass polar compounds were observed in aqueous side-fractions from the purification of okadaic acid (1) and dinophysistoxin-2 (2) from Dinophysis blooms in Spain and Norway. These were isolated and shown to be 24-O-β-d-glucosides of 1 and 2
Externí odkaz:
https://doaj.org/article/9decc81d37b24017a5806c3690b66fa5
Autor:
Jane Kilcoyne, Stephen Burrell, Cíara Nulty, Rafael Salas, Elliott J. Wright, Isabelle Rajotte, Christopher O. Miles
Publikováno v:
Marine Drugs, Vol 18, Iss 12, p 647 (2020)
Okadaic acid (OA) group toxins may accumulate in shellfish and can result in diarrhetic shellfish poisoning when consumed by humans, and are therefore regulated. Purified toxins are required for the production of certified reference materials used to
Externí odkaz:
https://doaj.org/article/ff812dc0c5324d37ac0cecf625d8f139
Autor:
Andreas Ballot, Thida Swe, Marit Mjelde, Leonardo Cerasino, Vladyslava Hostyeva, Christopher O. Miles
Publikováno v:
Toxins, Vol 12, Iss 4, p 232 (2020)
Meiktila Lake is a shallow reservoir located close to Meiktila city in central Myanmar. Its water is used for irrigation, domestic purposes and drinking water. No detailed study of the presence of cyanobacteria and their potential toxin production ha
Externí odkaz:
https://doaj.org/article/7a8c4c9854f241b2b5bbe83f87a7b2f3
Publikováno v:
Marine Drugs, Vol 18, Iss 4, p 182 (2020)
Ciguatera poisoning is linked to the ingestion of seafood that is contaminated with ciguatoxins (CTXs). The structural variability of these polyether toxins in nature remains poorly understood due to the low concentrations present even in highly toxi
Externí odkaz:
https://doaj.org/article/80ac6f8b16a146058ce3d472bc51e34e
Autor:
Patricia LeBlanc, Nadine Merkley, Krista Thomas, Nancy I. Lewis, Khalida Békri, Susan LeBlanc Renaud, Frances R. Pick, Pearse McCarron, Christopher O. Miles, Michael A. Quilliam
Publikováno v:
Toxins, Vol 12, Iss 2, p 77 (2020)
[D-Leu1]MC-LY (1) ([M + H]+ m/z 1044.5673, Δ 2.0 ppm), a new microcystin, was isolated from Microcystis aeruginosa strain CPCC-464. The compound was characterized by 1H and 13C NMR spectroscopy, liquid chromatography−high resolution tandem mass sp
Externí odkaz:
https://doaj.org/article/9ca323dd0ff04d349798f87f95ac7b43
Publikováno v:
Marine Drugs, Vol 17, Iss 11, p 643 (2019)
Microcystins are cyclic heptapeptides from cyanobacteria that are potent inhibitors of protein phosphatases and are toxic to animals and humans. At present, more than 250 microcystin variants are known, with variants reported for all seven peptide mo
Externí odkaz:
https://doaj.org/article/47d49b1b751249768f9a4facb76cce99