Zobrazeno 1 - 10
of 310
pro vyhledávání: '"Christopher O'callaghan"'
Autor:
Christopher O’Callaghan, Scott Berry, Petr Kavan, Jonathan M Loree, Felix Couture, Dongsheng Tu, Sheryl Koski, Lucy X Ma, Emma Titmuss, Derek J Jonker, Hagen F Kennecke, Chaudhary E Ahmad, John R Goffin, Mohammed Harb, Bruce Colwell, Setareh Samimi, Benoit Samson, Tahir Abbas, Nathalie Aucoin, Francine Aubin, Eric X Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 12 (2024)
Background Nutritional stress is a mechanism that allows tumor cells to evade the immune system. Arginine (ARG), an amino acid involved in immunomodulation, aids in regulating T-lymphocyte cell activity and the antitumor response. ARG deficiency in t
Externí odkaz:
https://doaj.org/article/049a1ab63a0c4bb59840eb50e1b906d5
Autor:
Annalan M.D. Navaratnam, Christopher O'Callaghan, Sarah Beale, Vincent Nguyen, Anna Aryee, Isobel Braithwaite, Thomas E. Byrne, Wing Lam Erica Fong, Ellen Fragaszy, Cyril Geismar, Susan Hoskins, Jana Kovar, Parth Patel, Madhumita Shrotri, Sophie Weber, Alexei Yavlinsky, Robert W. Aldridge, Andrew C. Hayward, Susan Michie, Pia Hardelid, Linda Wijlaars, Eleni Nastouli, Moira Spyer, Ben Killingley, Ingemar Cox, Vasileios Lampos, Rachel A. McKendry, Tao Cheng, Yunzhe Liu, Jo Gibbs, Richard Gilson, Alison Rogers, Anne M. Johnson
Publikováno v:
International Journal of Infectious Diseases, Vol 139, Iss , Pp 28-33 (2024)
Objectives: The importance of SARS-CoV-2 transmission via the eyes is unknown, with previous studies mainly focusing on protective eyewear in healthcare settings. This study aimed to test the hypothesis that wearing eyeglasses is associated with a lo
Externí odkaz:
https://doaj.org/article/226649ca8e6243bba90a57f7163b122c
Autor:
Charlie Rowlands, Huw B. Thomas, Jenny Lord, Htoo A. Wai, Gavin Arno, Glenda Beaman, Panagiotis Sergouniotis, Beatriz Gomes-Silva, Christopher Campbell, Nicole Gossan, Claire Hardcastle, Kevin Webb, Christopher O’Callaghan, Robert A. Hirst, Simon Ramsden, Elizabeth Jones, Jill Clayton-Smith, Andrew R. Webster, Genomics England Research Consortium, Andrew G. L. Douglas, Raymond T. O’Keefe, William G. Newman, Diana Baralle, Graeme C. M. Black, Jamie M. Ellingford
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The development of computational methods to assess pathogenicity of pre-messenger RNA splicing variants is critical for diagnosis of human disease. We assessed the capability of eight algorithms, and a consensus approach, to prioritize 249 v
Externí odkaz:
https://doaj.org/article/cff014b62747418fa2af4029a4e249c3
Autor:
Elizabeth F. Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H.C. Gowers, Celine Denais, Sandra Gómez-López, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian N.J. Woodall, Tereza Masonou, Katie-Marie Case, Vitor H. Teixeira, Benjamin E. Hartley, Richard J. Hewitt, Chadwan Al Yaghchi, Gurpreet S. Sandhu, Martin A. Birchall, Christopher O’Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105409- (2022)
Summary: The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related mole
Externí odkaz:
https://doaj.org/article/bc9bfc65a4564f5b8c32bca349dccceb
Autor:
Jeffrey Fong Ting Chau, Mianne Lee, Martin Man Chun Chui, Mullin Ho Chung Yu, Jasmine Lee Fong Fung, Christopher Chun Yu Mak, Christy Shuk-Kuen Chau, Ka Ka Siu, Jacqueline Hung, Kit San Yeung, Anna Ka Yee Kwong, Christopher O'Callaghan, Yu Lung Lau, Chun-Wai Davy Lee, Brian Hon-Yin Chung, So-Lun Lee
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Bronchiectasis is the abnormal dilation of the airway which may be caused by various etiologies in children. Beyond the more recognized cause of bacterial and viral infections and primary immunodeficiencies, other genetic conditions such as cystic fi
Externí odkaz:
https://doaj.org/article/1354567d67c147fb8a3fb1d9e75939ea
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background To aid in the diagnosis of Primary Ciliary Dyskinesia (PCD) and to evaluate the respiratory epithelium in respiratory disease, normal age-related reference ranges are needed for ciliary beat frequency (CBF), beat pattern and ultra
Externí odkaz:
https://doaj.org/article/e0bef698c5e94edaa0644b5bfea9a46b
Autor:
Wai-Yee Lam, Clara Sze-Man Tang, Man-Ting So, Haibing Yue, Jacob Shujui Hsu, Patrick Ho-Yu Chung, John M. Nicholls, Fanny Yeung, Chun-Wai Davy Lee, Diem Ngoc Ngo, Pham Anh Hoa Nguyen, Hannah M. Mitchison, Dagan Jenkins, Christopher O'Callaghan, Maria-Mercè Garcia-Barceló, So-Lun Lee, Pak-Chung Sham, Vincent Chi-Hang Lui, Paul Kwong-Hang Tam
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103530- (2021)
Background: Biliary atresia (BA) is the most common obstructive cholangiopathy in neonates, often progressing to end-stage cirrhosis. BA pathogenesis is believed to be multifactorial, but the genetic contribution, especially for nonsyndromic BA (comm
Externí odkaz:
https://doaj.org/article/de3d870458914c54bce3e247eeaeb86d
Autor:
Jason Oke, Rafael Perera, Christopher O’Callaghan, Jeffrey Aronson, Daniel Lasserson, Clare Taylor, Benjamin Feakins, Emily McFadden, Nathan Hill, Richard Stevens
Publikováno v:
BMJ Open, Vol 9, Iss 6 (2019)
Objectives To characterise serum creatinine and urinary protein testing in UK general practices from 2005 to 2013 and to examine how the frequency of testing varies across demographic factors, with the presence of chronic conditions and with the pres
Externí odkaz:
https://doaj.org/article/d5130728783744a4baf90a2bac54a706
Autor:
Neeta Kulkarni, Ahmad Kantar, Silvia Costella, Vincenzo Ragazzo, Giorgio Piacentini, Attilio Boner, Christopher O'Callaghan
Publikováno v:
Frontiers in Pediatrics, Vol 6 (2018)
Background and Objective: Airway macrophages perform the crucial functions of presenting antigens, clearing pathogens, and apoptotic cells. Macrophage phagocytosis is increased in adults with mild asthma and allergen exposure is known to activate mac
Externí odkaz:
https://doaj.org/article/6e74640dd0f24a0aa2d6c26016581503
Autor:
Robert A Hirst, Claire L Jackson, Janice L Coles, Gwyneth Williams, Andrew Rutman, Patricia M Goggin, Elizabeth C Adam, Anthony Page, Hazel J Evans, Peter M Lackie, Christopher O'Callaghan, Jane S Lucas
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89675 (2014)
The diagnosis of primary ciliary dyskinesia (PCD) requires the analysis of ciliary function and ultrastructure. Diagnosis can be complicated by secondary effects on cilia such as damage during sampling, local inflammation or recent infection. To diff
Externí odkaz:
https://doaj.org/article/f40fd44fc77f4bfc8bf5409717d71003