Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher N. Reyes"'
Autor:
Sabrina Müller, Daniel D. De Carvalho, David M. Underhill, George Y. Liu, Andrea J. Wolf, Gislâine A. Martins, Christopher N. Reyes, Moshe Arditi, Marisel Sanchez, Rajat Singhania, Stacey L. Kolar, Chihiro Ogawa
Publikováno v:
Cell hostmicrobe. 22(4)
Summary Humans do not usually develop effective immunity to Staphylococcus aureus reinfection. Using a murine model that mimics human infection, we show that lack of protective immunity to S. aureus systemic reinfection is associated with robust inte
Autor:
David M. Underhill, Moshe Arditi, Hee Cheol Cho, Kenichi Shimada, Andrea J. Wolf, K. Mark Coggeshall, Courtney A. Becker, Narcis I. Popescu, Matthew L. Wheeler, Wenbin Liang, Christopher N. Reyes
Publikováno v:
Cell, vol 166, iss 3
Degradation of Gram-positive bacterial cell wall peptidoglycan in macrophage and dendritic cell phagosomes leads to activation of the NLRP3 inflammasome, a cytosolic complex that regulates processing and secretion of interleukin (IL)-1β and IL-18. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3d345c32f891d2f36552a34f3f36eb
https://escholarship.org/uc/item/9jq258m6
https://escholarship.org/uc/item/9jq258m6
Autor:
Marla Dubinsky, David M. Underhill, Courtney A. Becker, Vincent Funari, Kent D. Taylor, Phillip Fleshner, Hanlin L. Wang, Jerome I. Rotter, Quoclinh Nguyen, Christopher N. Reyes, Jordan Brown, Iliyan D. Iliev, Gordon D. Brown, Dermot P.B. McGovern, Samuel P. Strom
Publikováno v:
Science. 336:1314-1317
The Mycobiome In the past few years, much attention has been given to the trillions of bacterial inhabitants in our guts and the myriad of ways in which they influence our overall health. But what about fungi? Iliev et al. (p. 1314 ) now report that
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 284:G85-G95
Treatments for pancreatitis are limited. Activation of transcription factor NF-kappaB, a key regulator of inflammatory molecule expression, is an early event in experimental pancreatitis and correlates with the inflammatory response. We report here t
L chain 3 (LC3)-associated phagocytosis is a process in which LC3, a protein canonically involved in engulfing intracellular materials (autophagy), is recruited to traditional phagosomes during internalization of extracellular payloads. LC3’s assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2be7f62bd8efb28986d4483eaae1b0
https://europepmc.org/articles/PMC3966112/
https://europepmc.org/articles/PMC3966112/
Autor:
Andrea Arruda, Moshe Arditi, David M. Underhill, Takahiro Shimada, George Y. Liu, Amber T. Kaplan, Kenichi Shimada, Andrea J. Wolf, Christopher N. Reyes
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(11)
Signaling by innate immune receptors initiates and orchestrates the overall immune responses to infection. Macrophage receptors recognizing pathogens can be broadly grouped into surface receptors and receptors restricted to intracellular compartments
Autor:
Christopher N. Reyes, Courtney A. Becker, Nandita Bose, Andrew S. Magee, Helen S. Goodridge, Michael E. Danielson, Anissa S.H. Chan, Andrea J. Wolf, David M. Underhill, Tamiko R. Katsumoto, Jun Ma, Arthur Weiss, John P. Vasilakos
Publikováno v:
Nature. 472(7344)
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by mye
Autor:
Iliyan D. Iliev, David M. Underhill, Courtney A. Becker, Vincent Funari, Christopher N. Reyes
Publikováno v:
Inflammatory Bowel Diseases. 18:S8-S9
Autor:
Shelly C. Lu, Christopher N. Reyes, Ilya Gukovsky, Teodoro Bottiglieri, Stephen J. Pandol, Aurelia Lugea, Lixin Chen, Zong-Zhi Huang, José M. Mato
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(1)
Severe necrotizing pancreatitis occurs in young female mice fed a choline-deficient and ethionine-supplemented (CDE) diet. Although the mechanism of the pancreatitis is unknown, one consequence of this diet is depletion of hepatic S-adenosylmethionin
Autor:
Christopher N. Reyes, Anna S. Gukovskaya, Larry D. Faller, Vladimir N. Kasho, Michelle Mouria, Ilya Gukovsky, Stephen J. Pandol
Publikováno v:
Gastroenterology. 122(1)
Background & Aims: Ethanol metabolism by pancreatic acinar cells and the role of its metabolites in ethanol toxicity to the pancreas remain largely unknown. Here, we characterize ethanol metabolism in pancreatic acinar cells and determine the effects