Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christopher N J, Young"'
Autor:
Liam D. Cassidy, Andrew R. J. Young, Christopher N. J. Young, Elizabeth J. Soilleux, Edward Fielder, Bettina M. Weigand, Anthony Lagnado, Rebecca Brais, Nicholas T. Ktistakis, Kimberley A. Wiggins, Katerina Pyrillou, Murray C. H. Clarke, Diana Jurk, Joao F. Passos, Masashi Narita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Autophagy declines with age, yet it is unclear if restoration of autophagy extends lifespan. Here, the authors demonstrate in murine models that the inhibition of Atg5 induces ageing phenotypes and reduces lifespan, whilst autophagy restoration parti
Externí odkaz:
https://doaj.org/article/08d9c43fad6f4fa996ca4382c883b9dc
Autor:
Rasha Al-Khalidi, Chiara Panicucci, Paul Cox, Natalia Chira, Justyna Róg, Christopher N. J. Young, Rhiannon E. McGeehan, Kameshwari Ambati, Jayakrishna Ambati, Krzysztof Zabłocki, Elisabetta Gazzerro, Stephen Arkle, Claudio Bruno, Dariusz C. Górecki
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Duchenne muscular dystrophy (DMD) is the most common inherited muscle disorder that causes severe disability and death of young men. This disease is characterized by progressive muscle degeneration aggravated by sterile inflammation and is a
Externí odkaz:
https://doaj.org/article/dd25d786045a4ae7b7f3c0189e811271
Autor:
João F. Passos, Anthony B. Lagnado, Elizabeth J. Soilleux, Katerina Pyrillou, Rebecca Brais, Nicholas T. Ktistakis, Liam D. Cassidy, Diana Jurk, Bettina M. Weigand, Masashi Narita, Murray C.H. Clarke, Kimberley A. Wiggins, Edward Fielder, Andrew R. J. Young, Christopher N. J. Young
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with increasing age, yet it is unknown if th
Autor:
Maziar Ashrafian Bonab, Mandana Ameli-Mojarad, Hosna Babini, Christopher N. J. Young, Ehsan Nazemalhosseini-Mojarad, Melika Ameli-Mojarad, Mahrooyeh Hadizadeh
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-16 (2021)
Cancer Cell International
Cancer Cell International
Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the ident
Autor:
Anthony Sinadinos, Christopher N J Young, Rasha Al-Khalidi, Anna Teti, Paweł Kalinski, Shafini Mohamad, Léonore Floriot, Tiphaine Henry, Gianluca Tozzi, Taiwen Jiang, Olivier Wurtz, Alexis Lefebvre, Mikhail Shugay, Jie Tong, David Vaudry, Stephen Arkle, Jean-Claude doRego, Dariusz C Górecki
Publikováno v:
PLoS Medicine, Vol 12, Iss 10, p e1001888 (2015)
BackgroundDuchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Death is caused by the progressive degeneration of striated muscles aggravated by sterile inflammation. The
Externí odkaz:
https://doaj.org/article/2382264224b74bba97356135e450e25b
Autor:
Michael Ladomery, Fakhrosadat Anaraki, Ehsan Nazemalhossini-Mojarad, Sarah Almond, Hamid Asadzadeh-Aghdaei, Mina Golmohammadi, Maziar Ashrafian Bonab, Hamid Rezvani, Sina Salari, Sama Rezasoltani, Mahrooyeh Hadizadeh, Christopher N. J. Young
Publikováno v:
Cancer Informatics
Cancer Informatics, Vol 19 (2020)
Cancer Informatics, Vol 19 (2020)
Aberrant activation of the WNT/CTNNB1 pathway is notorious in colorectal cancer (CRC). Here, we demonstrate that the expression of specific and crucial WNT signaling pathway genes is linked to disease progression in colonic adenomatous (AP) and hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e8719b5a91d70b7cf8cf39914b3f7e
Autor:
Sanaz Savabkar, Hamid Asadzadeh Aghdaei, Vahid Chaleshi, Maziar Ashrafian Bonab, Christopher N. J. Young, Mahrooyeh Hadizadeh, Shiva Irani, Reza Mirfakhraie, Elham Kashani
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 519 (2019)
Biomolecules
Volume 9
Issue 10
Biomolecules
Volume 9
Issue 10
open access article Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, representing 13% of all cancers. The role of epigenetics in cancer diagnosis and prognosis is well established. MicroRNAs in particular influence numer
Autor:
J. Dunlop, Darek Gorecki, Aleksandra Oksiejuk, Maxime R. F. Gosselin, Kacper Łukasiewicz, Natalia Chira, Paweł Matryba, Robin M. H. Rumney, Alexander P. Kao, Christopher N. J. Young, Samuel Robson, Krzysztof Zabłocki, Lukasz Bozycki
Publikováno v:
Young, C, Gosselin, M R F, Rumney, R M H, Oksiejuk, A, Chira, N, Bozycki, L, Matryba, P, Łukasiewicz, K, Kao, A, Dunlop, J N, Robson, S, Zabłocki, K & Gorecki, D 2020, ' Total absence of dystrophin expression exacerbates ectopic myofiber calcification and fibrosis and alters macrophage infiltration patterns ', American Journal of Pathology, vol. 190, no. 1, pp. 190-205 . https://doi.org/10.1016/j.ajpath.2019.09.021
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Duchenne muscular dystrophy (DMD) causes severe disability and death of young men due to progressive m
Autor:
João F. Passos, Liam D. Cassidy, Kimberley A. Wiggins, Rebecca Brais, Diana Jurk, Christopher N. J. Young, Masashi Narita, Edward Fielder, Andrew R. J. Young, Bettina M Weigand, Murray C.H. Clarke, Elizabeth J. Soilleux
Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to aging. A decrease in autophagy is associated with increasing age, yet it is unknown if thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d741b435c09772814e7f0d75b41a01
https://doi.org/10.1101/528984
https://doi.org/10.1101/528984
Autor:
Mark D. Evans, Michael J. Randles, Christopher N. J. Young, María Á. Peña, Antonio Peña-Fernández
Publikováno v:
INTED Proceedings.