NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z.

Autor: Christopher M Ziegler, Loan Dang, Philip Eisenhauer, Jamie A Kelly, Benjamin R King, Joseph P Klaus, Inessa Manuelyan, Ethan B Mattice, David J Shirley, Marion E Weir, Emily A Bruce, Bryan A Ballif, Jason Botten

Publikováno v: PLoS Pathogens, Vol 15, Iss 11, p e1008100 (2019)

Viral late domains are used by many viruses to recruit the cellular endosomal sorting complex required for transport (ESCRT) to mediate membrane scission during viral budding. Unlike the P(S/T)AP and YPX(1-3)L late domains, which interact directly wi

Externí odkaz: https://doaj.org/article/b77f00b06c8a41729f32479998049880

Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle  pre-assembly

Autor: Emily A. Bruce, Philip Eisenhauer, Jason Botten, Christopher M. Ziegler, Benjamin R. King, Daniel Zenklusen, Samuel Kellner

Publikováno v: The Journal of General Virology

We report a fluorescence in situ hybridization (FISH) assay that allows the visualization of lymphocytic choriomeningitis mammarenavirus (LCMV) genomic RNAs in individual cells. We show that viral S segment genomic and antigenomic RNA, along with vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d91232ac494b1393ec0bbdbd3f6b65
https://doi.org/10.1099/jgv.0.000930

Host-Driven Phosphorylation Appears to Regulate the Budding Activity of the Lassa Virus Matrix Protein

Autor: Bryan A. Ballif, Christopher M. Ziegler, Jason Botten, Inessa Manuelyan, Marion E. Weir, Emily A. Bruce, Philip Eisenhauer

Publikováno v: Pathogens
Pathogens, Vol 7, Iss 4, p 97 (2018)

Lassa mammarenavirus (LASV) is an enveloped RNA virus that can cause Lassa fever, an acute hemorrhagic fever syndrome associated with significant morbidity and high rates of fatality in endemic regions of western Africa. The arenavirus matrix protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b668bdaf6b82e97d9655346c4c0a1d
http://europepmc.org/articles/PMC6313517

Visualization of Arenavirus RNA Species in Individual Cells by Single-Molecule Fluorescence In Situ Hybridization Suggests a Model of Cyclical Infection and Clearance during Persistence

Autor: Christopher M. Ziegler, Florian Mueller, Emily A. Bruce, Philip Eisenhauer, Daniel Zenklusen, Benjamin R. King, Aubin Samacoits, Christophe Zimmer, Jason Botten

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2018, 92 (12), pp.e2241-17. ⟨10.1128/JVI.02241-17⟩
Journal of Virology, 2018, 92 (12), pp.e2241-17. ⟨10.1128/JVI.02241-17⟩

Lymphocytic choriomeningitis mammarenavirus (LCMV) is an enveloped, negative-strand RNA virus that causes serious disease in humans but establishes an asymptomatic, lifelong infection in reservoir rodents. Different models have been proposed to descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc772f98ceaf453b6b3d9dc5f080187
https://hal-pasteur.archives-ouvertes.fr/pasteur-02075021

Visualization of Arenavirus RNA Species in Individual Cells by Single-Molecule Fluorescence

Autor: Benjamin R, King, Aubin, Samacoits, Philip L, Eisenhauer, Christopher M, Ziegler, Emily A, Bruce, Daniel, Zenklusen, Christophe, Zimmer, Florian, Mueller, Jason, Botten

Publikováno v: Journal of virology. 92(12)

Lymphocytic choriomeningitis mammarenavirus (LCMV) is an enveloped, negative-strand RNA virus that causes serious disease in humans but establishes an asymptomatic, lifelong infection in reservoir rodents. Different models have been proposed to descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c77ca46721c2adbb4ee12800c7af3114
https://pubmed.ncbi.nlm.nih.gov/29643234