Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher M. Woodley"'
Autor:
Laura-Oana Albulescu, Adam Westhorpe, Rachel H. Clare, Christopher M. Woodley, Nivya James, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors
Externí odkaz:
https://doaj.org/article/e44e33036d7043608452939fe49851f5
Autor:
Rachel H. Clare, Charlotte A. Dawson, Adam Westhorpe, Laura-Oana Albulescu, Christopher M. Woodley, Nada Mosallam, Daniel J. W. Chong, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Snakebite envenoming results in ∼100,000 deaths per year, with close to four times as many victims left with life-long sequelae. Current antivenom therapies have several limitations including high cost, variable cross-snake species efficacy and a r
Externí odkaz:
https://doaj.org/article/c67978e66f4041d2bd395e92866c736a
Autor:
Ali H Alghamdi, Jane C Munday, Gustavo Daniel Campagnaro, Dominik Gurvic, Fredrik Svensson, Chinyere E Okpara, Arvind Kumar, Juan Quintana, Maria Esther Martin Abril, Patrik Milić, Laura Watson, Daniel Paape, Luca Settimo, Anna Dimitriou, Joanna Wielinska, Graeme Smart, Laura F Anderson, Christopher M Woodley, Siu Pui Ying Kelly, Hasan MS Ibrahim, Fabian Hulpia, Mohammed I Al-Salabi, Anthonius A Eze, Teresa Sprenger, Ibrahim A Teka, Simon Gudin, Simone Weyand, Mark Field, Christophe Dardonville, Richard R Tidwell, Mark Carrington, Paul O'Neill, David W Boykin, Ulrich Zachariae, Harry P De Koning
Publikováno v:
eLife, Vol 9 (2020)
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that
Externí odkaz:
https://doaj.org/article/04cf21046dd94dac9faba5a20eaa5348
Autor:
Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, Christopher M Woodley, Keiko Onuma, Suet C. Leung, Paul M. O'Neill, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward, Takashi Hasebe, Weiqian David Hong
Publikováno v:
ACS Med Chem Lett
[Image: see text] Synthetic endoperoxide antimalarials, such as 1,2,4-trioxolanes and 1,2,4,5-tetraoxanes, are promising successors for current front-line antimalarials, semisynthetic artemisinin derivatives. However, limited solubility of second-gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabef208cdad2cca3bf319febc3587b4
https://doi.org/10.1021/acsmedchemlett.1c00031
https://doi.org/10.1021/acsmedchemlett.1c00031
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
MEDICINAL RESEARCH REVIEWS
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
MEDICINAL RESEARCH REVIEWS
Artemisinin combination therapies (ACTs) have been used as the first-line treatments against Plasmodium falciparum malaria for decades. Recent advances in chemical proteomics have shed light on the complex mechanism of action of semi-synthetic artemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7fa1bcb987e730238df66192d7d471
https://hdl.handle.net/10400.1/17140
https://hdl.handle.net/10400.1/17140
Autor:
Anna Dimitriou, Daniel Paape, Christopher M Woodley, Ulrich Zachariae, Anthonius A. Eze, Simone Weyand, Ibrahim A. Teka, Ali H. Alghamdi, Richard R. Tidwell, Arvind Kumar, Jane C. Munday, Juan F. Quintana, Mark Carrington, Mohammed I. Al-Salabi, Paul M. O'Neill, Laura F Anderson, Maria Esther Martin Abril, Harry P. de Koning, Teresa Sprenger, Hasan M. S. Ibrahim, Fredrik Svensson, Simon Gudin, Fabian Hulpia, Patrik Milic, Chinyere E Okpara, Gustavo D. Campagnaro, Dominik Gurvic, Graeme Smart, David W. Boykin, Christophe Dardonville, Luca Settimo, Siu Pui Ying Kelly, Laura Watson, Joanna Wielinska, Mark C. Field
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa648917f3111794e8be1fa4dd747110
https://doi.org/10.7554/elife.56416.sa2
https://doi.org/10.7554/elife.56416.sa2
Autor:
Harry P. de Koning, Ibrahim A. Teka, Hasan M. S. Ibrahim, Christopher M Woodley, Simon Gudin, Patrik Mili, Arvind Kumar, Daniel Paape, Fredrik Svensson, Fabian Hulpia, Jane C. Munday, Mark Carrington, Mohammed I. Al-Salabi, Dominik Gurvic, Laura F Anderson, Christophe Dardonville, David W. Boykin, Chinyere E Okpara, Ali H. Alghamdi, Luca Settimo, Laura Watson, Maria Esther Martin Abril, Joanna Wielinska, Gustavo D. Campagnaro, Graeme Smart, Ulrich Zachariae, Anthonius A. Eze, Richard R. Tidwell, Anna Dimitriou, Siu Pui Ying Kelly, Paul M. O'Neill
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a2c3019e9ca4c7a9a0aacc54e2b6b
Autor:
Paul M. O'Neill, Harry P. de Koning, Anna Dimitriou, Ulrich Zachariae, Joanna Wielinska, Arvind Kumar, Anthonius A. Eze, Mark C. Field, Chinyere E Okpara, Juan F. Quintana, Richard R. Tidwell, Simone Weyand, Luca Settimo, Siu Pui Ying Kelly, Christopher M Woodley, Dominik Gurvic, Ibrahim A. Teka, Mohammed I. Al-Salabi, Fredrik Svensson, Fabian Hulpia, Ali H. Alghamdi, Patrik Milic, Teresa Sprenger, Hasan M. S. Ibrahim, David W. Boykin, Laura Watson, Laura F Anderson, Daniel Paape, Mark Carrington, Maria Esther Martin Abril, Simon Gudin, Gustavo D. Campagnaro, Graeme Smart, Jane C. Munday, Christophe Dardonville
Publikováno v:
ELIFE
eLife
eLife, Vol 9 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
eLife
eLife, Vol 9 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a8612e3af4438b62845ec7d02b257f
https://biblio.ugent.be/publication/8671473
https://biblio.ugent.be/publication/8671473