Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christopher M. Treleaven"'
Autor:
James C. Dodge, Thomas J. Tamsett, Christopher M. Treleaven, Tatyana V. Taksir, Peter Piepenhagen, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to ear
Externí odkaz:
https://doaj.org/article/117f28947efd422dbf60d1918e6bc62d
Autor:
Seng H. Cheng, S. Pablo Sardi, Elina Makino, Catherine Viel, James Dodge, Christopher M. Treleaven, Maureen A. Olszewski, Hyejung Park, Lamya S. Shihabuddin, Richard L. Sidman, Amy M. Richards, Bing Wang, John Marshall, Jennifer Clarke
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2699-2704
Mutations in the glucocerebrosidase gene (GBA) confer a heightened risk of developing Parkinson's disease (PD) and other synucleinopathies, resulting in a lower age of onset and exacerbating disease progression. However, the precise mechanisms by whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827ad5f1403b8d4410cead9885bdc1ce
https://doi.org/10.1073/pnas.1616152114
https://doi.org/10.1073/pnas.1616152114
Autor:
Jonathan A. Fidler, Kuma Misra, Christopher M. Treleaven, Richard L. Sidman, Thomas J. Tamsett, Seng H. Cheng, James Dodge, Tatyana V. Taksir, Channa Bao, Lamya S. Shihabuddin, Michelle Searles
Publikováno v:
Proceedings of the National Academy of Sciences. 110:10812-10817
Metabolic dysfunction is an important modulator of disease course in amyotrophic lateral sclerosis (ALS). We report here that a familial mouse model (transgenic mice over-expressing the G93A mutation of the Cu/Zn superoxide dismutase 1 gene) of ALS e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe609911cb4c5deaa2ca2b50df1d521
https://doi.org/10.1073/pnas.1308421110
https://doi.org/10.1073/pnas.1308421110
Autor:
Eliezer Masliah, Christopher M. Treleaven, Catherine Viel, S. Pablo Sardi, Brian Spencer, Anthony Adame, James Dodge, Edward Rockenstein, Hyejung Park, Nicholas M. Panarello, Seng H. Cheng, Lamya S. Shihabuddin, Changyoun Kim, Jennifer Clarke
Publikováno v:
Human Molecular Genetics
Mutations in GBA1, the gene encoding glucocerebrosidase, are associated with an enhanced risk of developing synucleinopathies such as Parkinson's disease (PD) and dementia with Lewy bodies. A higher prevalence and increased severity of motor and non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b19e3dd14a1d5300267f024ee3fc829
https://pubmed.ncbi.nlm.nih.gov/27126635
https://pubmed.ncbi.nlm.nih.gov/27126635
Autor:
S. Pablo Sardi, Marco A. Passini, Jie Bu, Lisa Woodworth, Gregory D Hurlbut, James Dodge, Lamya S. Shihabuddin, Christopher M. Treleaven, Thomas J. Tamsett, Jonathan A. Fidler, Seng H. Cheng
Publikováno v:
Molecular Therapy. 20(9):1713-1723
Central nervous system (CNS)-directed gene therapy with recombinant adeno-associated virus (AAV) vectors has been used effectively to slow disease course in mouse models of several neurodegenerative diseases. However, these vectors were typically tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ee5a62c935de9e9063c0e85666c9ef
Autor:
Christopher M. Treleaven, Robin J. Ziegler, Ernesto A. Salegio, Krystof S. Bankiewicz, John Bringas, Thomas J. Tamsett, Massimo S. Fiandaca, Scott D. Bercury, James Dodge, Piotr Hadaczek, Lamya S. Shihabuddin, Ronald K. Scheule
Publikováno v:
Experimental Neurology. 231:261-271
One treatment approach for lysosomal storage diseases (LSDs) is the systemic infusion of recombinant enzyme. Although this enzyme replacement is therapeutic for the viscera, many LSDs have central nervous system (CNS) components that are not adequate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e38067e2527ba8f55f2d5f4fcc73940
https://doi.org/10.1016/j.expneurol.2011.06.019
https://doi.org/10.1016/j.expneurol.2011.06.019
Autor:
Ashley E. Frakes, Brian K. Kaspar, Seng H. Cheng, Jonathan A. Fidler, Thomas J. Tamsett, Mary E. McCrate, Lamya S. Shihabuddin, Christopher M. Treleaven, James Dodge
Publikováno v:
The FASEB Journal. 25:4369-4377
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron cell loss, muscular atrophy, and a shortened life span. Survival is highly variable, as some patients die within months, while others live fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9706d3d748affe5be85c57ba0797213
https://doi.org/10.1096/fj.11-190819
https://doi.org/10.1096/fj.11-190819
Autor:
Seng H. Cheng, James Dodge, Tatyana V. Taksir, Lamya S. Shihabuddin, Richard L. Sidman, Jonathan A. Fidler, Christopher M. Treleaven, Wendy Yang
Publikováno v:
Experimental Neurology. 227:287-295
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. However, recent reports suggest an active role of non-neuronal cells in the pathogenesis of the disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386bb4e59cd3a9ea10d3ffc5d8ff3007
https://doi.org/10.1016/j.expneurol.2010.11.019
https://doi.org/10.1016/j.expneurol.2010.11.019
Autor:
Jonathan A. Fidler, Jennifer C Matthews, Meghan Rao, Amy Eagle, Christopher M. Treleaven, Brian K. Kaspar, Chalonda R. Handy, Tatyana V. Taksir, Seng H. Cheng, Amanda M. Haidet, Mark E. Hester, Lamya S. Shihabuddin, James Dodge
Publikováno v:
Molecular Therapy. 18:2075-2084
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron cell death in the cortex, brainstem, and spinal cord. Extensive efforts have been made to develop trophic factor-based therapies to enhance motor n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f44cc3653c4ab8049a3a76a6597488d
https://doi.org/10.1038/mt.2010.206
https://doi.org/10.1038/mt.2010.206
Autor:
Seng H. Cheng, Edward H. Schuchman, Jonathan A. Fidler, Christopher M. Treleaven, Marco A. Passini, Kenneth P. Karey, Denise Griffiths, Wendy Yang, Tatyana V. Taksir, Lamya S. Shihabuddin, James Dodge, Jennifer Clarke
Publikováno v:
Experimental Neurology. 215:349-357
Niemann-Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity. Previously, we showed that the storage pathology in the ASM knockout (ASMKO) mouse brain could be corrected by intracer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90be1695519f0d90b468493266c95301
https://doi.org/10.1016/j.expneurol.2008.10.021
https://doi.org/10.1016/j.expneurol.2008.10.021