Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher M. Rasik"'
Publikováno v:
Journal of the American Chemical Society. 138:2437-2442
Described herein are synthetic efforts toward the synthesis of hippolachnin A. Two independently devised routes from the Brown and Wood groups allowed for the synthesis of hippolachnin A from the unusual starting material, quadricyclane, by harnessin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79b47fdaf3923b38635dff2eb8b219d
https://doi.org/10.1021/jacs.5b13586
https://doi.org/10.1021/jacs.5b13586
Autor:
M. Kevin Brown, Christopher M. Rasik
Publikováno v:
Angewandte Chemie. 126:14750-14754
The first synthesis of gracilioether F, a polyketide natural product with an unusual tricyclic core and five contiguous stereocenters, is described. Key steps of the synthesis include a Lewis acid promoted ketene-alkene [2+2] cycloaddition and a late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f4e2780ced68006f0061791cab3a6e
https://doi.org/10.1002/ange.201408055
https://doi.org/10.1002/ange.201408055
Intermolecular Ketene–Alkene [2+2] Cycloadditions: The Significance of Lewis Acid Promoted Variants
Autor:
M. Kevin Brown, Christopher M. Rasik
Publikováno v:
Synlett. 25:760-765
Ketene–alkene [2+2] cycloadditions are an important class of reactions for chemical synthesis. These processes were exclusively carried out under thermal conditions, which ultimately lead to limitations regarding scope and stereoselectivity. Review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e70edd2c3301bf383dbcac2fd45dc5a0
https://doi.org/10.1055/s-0033-1340626
https://doi.org/10.1055/s-0033-1340626
Autor:
Christopher M. Rasik, M. Kevin Brown
Publikováno v:
Journal of the American Chemical Society. 135:1673-1676
Described are the first examples of ketene-alkene [2 + 2] cycloadditions promoted by Lewis acids. Notable features of this method include (1) substantial rate acceleration relative to traditional thermal reactions, (2) good diastereoselectivities and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcae0f3eb2e19cfe932c636955dddf06
https://doi.org/10.1021/ja3103007
https://doi.org/10.1021/ja3103007
Publikováno v:
ChemInform. 47
A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ecb246a4c412d3d8b3e6d88b21ae866
https://doi.org/10.1002/chin.201643062
https://doi.org/10.1002/chin.201643062
A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d155074da8fc3d072f8d53b74cad354c
https://europepmc.org/articles/PMC4814371/
https://europepmc.org/articles/PMC4814371/
Publikováno v:
Organic letters. 16(19)
A detailed analysis of a Lewis acid promoted ketene–alkene [2 + 2] cycloaddition is reported. The studies have led to a rationalization for an observed inversion of diastereoselectivity between thermally induced and Lewis acid promoted ketene–alk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b867f1a3da21e85cf4a794910348aa
https://pubmed.ncbi.nlm.nih.gov/25230201
https://pubmed.ncbi.nlm.nih.gov/25230201
Autor:
Christopher M. Rasik, M. Kevin Brown
Publikováno v:
ChemInform. 45
Ketene–alkene [2+2] cycloadditions are an important class of reactions for chemical synthesis. These processes were exclusively carried out under thermal conditions, which ultimately lead to limitations regarding scope and stereoselectivity. Review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1b1f77b7a1e7d8b0158389561bc9f4
https://doi.org/10.1002/chin.201425263
https://doi.org/10.1002/chin.201425263
Autor:
Christopher M. Rasik, M. Kevin Brown
Publikováno v:
ChemInform. 44
Ketenes, generated in situ or isolated, react with various cyclic and linear alkenes in the presence of EtAlCl2 to afford the cycloaddition products with moderate to high diastereoselectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::943de1e2e7075eec7c30bced08ac099c
https://doi.org/10.1002/chin.201329050
https://doi.org/10.1002/chin.201329050