Výsledky vyhledávání - "Christopher M. Mahaffey"

Aberrant Regulation of the MRP3 Gene in Non-small Cell Lung Carcinoma

Autor: David R. Gandara, Hongqiao Zhang, Henry Jay Forman, W. S. Holland, Nichole Mahaffey, Christopher M. Mahaffey, Philip C. Mack

Publikováno v: Journal of Thoracic Oncology. 7:34-39

IntroductionMultidrug-resistant protein-3 (MRP3), a membrane-bound transporter, facilitates efflux of toxic compounds, including certain chemotherapies, out of cells. Aberrant MRP3 expression has been linked to drug resistance in non-small cell lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6079a891e933a81bde54707cb7d5dcc
https://doi.org/10.1097/jto.0b013e318233d753

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Dual Blockade of PKA and NF–κB Inhibits H2 Relaxin-Mediated Castrate-Resistant Growth of Prostate Cancer Sublines and Induces Apoptosis

Autor: Regina F Gandour-Edwards, Ruth Louise Vinall, Clifford G. Tepper, Ralph W deVere White, Ryan R. Davis, Paramita M. Ghosh, Zunping Luo, Christopher M. Mahaffey

Publikováno v: Hormones and Cancer. 2:224-238

We previously demonstrated that H2 relaxin (RLN2) facilitates castrate-resistant (CR) growth of prostate cancer (CaP) cells through PI3K/Akt/β-catenin-mediated activation of the androgen receptor (AR) pathway. As inhibition of this pathway caused on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0852d6c238c83c3b6c16e74c65f1a15
https://doi.org/10.1007/s12672-011-0076-4

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Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma

Autor: Philip C. Mack, Henry Jay Forman, Christopher M. Mahaffey, Alessandra Rinna, W. S. Holland, Hongqiao Zhang

Publikováno v: Free radical biologymedicine. 46(12)

Multidrug Resistant Proteins (MRP) are members of the ATP-binding cassette superfamily that facilitate detoxification by transporting toxic compounds, including chemotherapeutic drugs, out of cells. Chemotherapy, radiation, and other xenobiotic stres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48f4d5e7b05e45b3286515291ecedd3
https://pubmed.ncbi.nlm.nih.gov/19345732

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Schedule-dependent apoptosis in K-ras mutant non-small-cell lung cancer cell lines treated with docetaxel and erlotinib: rationale for pharmacodynamic separation

Autor: W. S. Holland, David R. Gandara, Brandi Pryde, Paul H. Gumerlock, Philip C. Mack, Christopher M. Mahaffey, Angela M. Davies, Jr Primo N. Lara

Publikováno v: Clinical lung cancer. 8(9)

BACKGROUND Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) given concurrently with chemotherapy in 4 large randomized clinical trials did not improve patient outcomes compared with chemotherapy alone in advanced non–small-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8359aac5fbb343ea00a3333598d65154
https://pubmed.ncbi.nlm.nih.gov/18186959

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The HB22.7 Anti-CD22 monoclonal antibody enhances bortezomib-mediated lymphomacidal activity in a sequence dependent manner

Autor: Yunpeng Ma, Shiloh M. Martin, Hayes McKnight, Robert T. O'Donnell, Christopher M. Mahaffey, Eric Churchill, Joseph Tuscano

Publikováno v: Journal of Hematology & Oncology
Martin, Shiloh M; Churchill, Eric; McKnight, Hayes; Mahaffey, Christopher M; Ma, Yunpeng; O'Donnell, Robert T; et al.(2011). The HB22.7 Anti-CD22 Monoclonal Antibody Enhances Bortezomib-mediated Lymphomacidal Activity in a Sequence Dependent Manner. Journal of Hematology & Oncology, 4(1), 49. doi: http://dx.doi.org/10.1186/1756-8722-4-49. Retrieved from: http://www.escholarship.org/uc/item/2k29s3d3
Journal of Hematology & Oncology, Vol 4, Iss 1, p 49 (2011)

Most non-Hodgkin's lymphomas (NHL) initially respond to chemotherapy, but relapse is common and treatment is often limited by chemotherapy-related toxicity. Bortezomib, is a highly selective proteasome inhibitor with anti-NHL activity; it is currentl

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