Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christopher M. Lauderback"'
Publikováno v:
Neurobiology of Aging. 23:655-664
Amyloid β-peptide [Aβ(1–42)] is central to the pathogenesis of Alzheimer’s disease (AD), and the AD brain is under intense oxidative stress, including membrane lipid peroxidation. Aβ(1–42) causes oxidative stress in and neurotoxicity to neur
Publikováno v:
Free Radical Biology and Medicine. 32:1050-1060
Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer’s disease (AD) patients, and free radical oxidative stress, particularly of neuronal lipids and proteins, is extensive. Recent research suggests that these two observations ma
Autor:
Jeffery N. Keller, Mark S. Kindy, William R. Markesbery, David Allan Butterfield, Christopher M. Lauderback, Jin Yu
Publikováno v:
Journal of Neurochemistry. 74:1579-1586
Apolipoprotein E (apoE) is present in the brain and may contribute to neurophysiologic or neuropathologic events, depending on environmental and genetic influences. Recent studies indicate a role for apoE in synaptic plasticity and maintenance of syn
Autor:
Janna M. Hackett, Jaroslaw Kanski, Mark S. Kindy, D. Allan Butterfield, Christopher M. Lauderback, Noboyo Maeda
Publikováno v:
Brain Research. 924:90-97
Several functional differences have been reported among the three human e2, e3, and e4 alleles of apolipoprotein E (apoE). One functional difference lies in the antioxidant potential of these alleles; e4 has the poorest potential. Interestingly, e4 a
Autor:
Luke I. Szweda, D. Allan Butterfield, Janna M. Hackett, William R. Markesbery, Feng F. Huang, Christopher M. Lauderback, Jeffrey N. Keller
Publikováno v:
Journal of Neurochemistry. 78:413-416
Glutamate transporters are involved in the maintenance of synaptic glutamate concentrations. Because of its potential neurotoxicity, clearance of glutamate from the synaptic cleft may be critical for neuronal survival. Inhibition of glutamate uptake
Publikováno v:
Neurochemical Research. 26:23-29
The antioxidant properties of 5-aminosalicylic acid in vitro were evaluated in a synaptosomal membrane system prepared from gerbil cortical synaptosomes using EPR spin labeling and spectroscopic techniques. MAL-6 (2,2,6,6-tetramethyl-4-maleimidopiper
Autor:
Sridhar Varadarajan, Adam M. Breier, D. Allan Butterfield, Christopher M. Lauderback, Jessica Goodlett-Mercer, Janna M. Hackett
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1501(2-3):149-161
The pyrrolopyrimidine U101033E is a therapeutic compound potentially useful in stroke, head injury and other oxidative stress conditions. Electron paramagnetic resonance (EPR) techniques of spin labeling and spin trapping in conjunction with measures
Autor:
Marina V. Aksenova, D. Allan Butterfield, Sridhar Varadarajan, Jaroslaw Kanski, Christopher M. Lauderback
Publikováno v:
ChemInform. 32
Oxidative stress induced by amyloid ‚-peptide (A‚) has been implicated in the neurodegeneration observed in Alzheimer's disease (AD) brain. However, the mechanism by which the predominant form of A‚ found in AD brains, A‚(1-42), causes oxidat
Publikováno v:
Brain research. 1004(1-2)
Membrane lipid bilayer asymmetry is maintained by the ATP-dependent enzyme flippase. An early signal of synaptosomal apoptosis is the loss of phospholipid asymmetry and the appearance of phosphatidylserine (PS) in the outer leaflet of the membrane. T
Autor:
Daohong Zhou, Christopher M. Lauderback, Sridhar Varadarajan, Maria Tsoras, Jennifer Drake, Jaroslaw Kanski, Janna M. Hackett, D. Allan Butterfield, Alessandra Castegna
Publikováno v:
Free radical research. 37(4)
Xanthic acids have long been known to act as reducing agents. Recently, D609, a tricyclodecanol derivative of xanthic acid, has been reported to have anti-apoptotic and anti-inflammatory properties that are attributed to specific inhibition of phosph