Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Christopher M. Jakobson"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Genetic architecture underlies the complexity of heritable traits. Here, the authors perform high-resolution genetic mapping of metabolic traits in S. cerevisiae and show evidence for selection across standing genetic variation.
Externí odkaz:
https://doaj.org/article/1ed839d5d9144e5e8ad6d515ba529786
Autor:
Emily C. Hartman, Christopher M. Jakobson, Andrew H. Favor, Marco J. Lobba, Ester Álvarez-Benedicto, Matthew B. Francis, Danielle Tullman-Ercek
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Self-assembling proteins have important applications in industrial technologies, but it is difficult to predict how mutations affect assembly. Here the authors present SyMAPS, coupling comprehensive codon mutagenesis with high-throughput sequencing,
Externí odkaz:
https://doaj.org/article/32650acf858e4272b1227a70f3e4f8ee
Autor:
David M Garcia, Edgar A Campbell, Christopher M Jakobson, Mitsuhiro Tsuchiya, Ethan A Shaw, Acadia L DiNardo, Matt Kaeberlein, Daniel F Jarosz
Publikováno v:
eLife, Vol 10 (2021)
In fluctuating environments, switching between different growth strategies, such as those affecting cell size and proliferation, can be advantageous to an organism. Trade-offs arise, however. Mechanisms that aberrantly increase cell size or prolifera
Externí odkaz:
https://doaj.org/article/418f66c5630d4db19a8f8ec90c1a9440
Publikováno v:
Nature Cell Biology. 23:1053-1055
Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reve
Publikováno v:
Annual Review of Genetics. 54:439-464
The complexity of heredity has been appreciated for decades: Many traits are controlled not by a single genetic locus but instead by polymorphisms throughout the genome. The importance of complex traits in biology and medicine has motivated diverse a
Autor:
Matt Kaeberlein, Edgar A Campbell, David M Garcia, Ethan A Shaw, Acadia L DiNardo, Daniel F. Jarosz, Christopher M. Jakobson, Mitsuhiro Tsuchiya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95aeaf36aa3b28afcd7120be4b6bba47
https://doi.org/10.7554/elife.60917.sa2
https://doi.org/10.7554/elife.60917.sa2
Autor:
Edgar A Campbell, Daniel F. Jarosz, David M Garcia, Ethan A Shaw, Christopher M. Jakobson, Acadia L DiNardo, Matt Kaeberlein, Mitsuhiro Tsuchiya
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
In fluctuating environments, switching between different growth strategies, such as those affecting cell size and proliferation, can be advantageous to an organism. Trade-offs arise, however. Mechanisms that aberrantly increase cell size or prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7dbe3d019539bb6c8a6665b49b484a
https://doi.org/10.1101/2020.07.10.196584
https://doi.org/10.1101/2020.07.10.196584
Publikováno v:
Microbial Cell Factories, Vol 17, Iss 1, Pp 1-10 (2018)
Microbial Cell Factories
Microbial Cell Factories
Biotechnological processes use microbes to convert abundant molecules, such as glucose, into high-value products, such as pharmaceuticals, commodity and fine chemicals, and energy. However, from the outset of the development of a new bioprocess, it i
Publikováno v:
ACS Synthetic Biology. 6:1880-1891
Bacterial microcompartments are a class of proteinaceous organelles comprising a characteristic protein shell enclosing a set of enzymes. Compartmentalization can prevent escape of volatile or toxic intermediates, prevent off-pathway reactions, and c
Publikováno v:
Protein Science. 26:1086-1092
Organizing heterologous biosyntheses inside bacterial cells can alleviate common problems owing to toxicity, poor kinetic performance, and cofactor imbalances. A subcellular organelle known as a bacterial microcompartment, such as the 1,2-propanediol