Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Christopher M. Hovens"'
Autor:
Yangyi Zhang, Bethany K. Campbell, Stanley S. Stylli, Niall M. Corcoran, Christopher M. Hovens
Publikováno v:
Uro, Vol 2, Iss 2, Pp 74-92 (2022)
Advanced prostate cancers have a poor survival rate and a lack of effective treatment options. In order to broaden the available treatments, immunotherapies have been investigated. These include cancer vaccines, immune checkpoint inhibitors, chimeric
Externí odkaz:
https://doaj.org/article/263f8799ad8e4859b4614d2ddb36e925
Autor:
Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams, Anthony J. Costello, Paul J. Neeson, Bhupinder Pal, Nicholas D. Huntington, Niall M. Corcoran, Anthony T. Papenfuss, Christopher M. Hovens
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-18 (2021)
Abstract Background Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tumour microenvironment
Externí odkaz:
https://doaj.org/article/6df753fdc4cc463099e2cb3f0e220186
Autor:
Edmund Lau, Patrick McCoy, Fairleigh Reeves, Ken Chow, Michael Clarkson, Edmond M. Kwan, Kate Packwood, Helen Northen, Miao He, Zoya Kingsbury, Stefano Mangiola, Michael Kerger, Marc A. Furrer, Helen Crowe, Anthony J. Costello, David J. McBride, Mark T. Ross, Bernard Pope, Christopher M. Hovens, Niall M. Corcoran
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-11 (2020)
Abstract Background DNA originating from degenerate tumour cells can be detected in the circulation in many tumour types, where it can be used as a marker of disease burden as well as to monitor treatment response. Although circulating tumour DNA (ct
Externí odkaz:
https://doaj.org/article/dff3ff03bc4d479295f4bcd8450cf3d3
Autor:
Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, PCAWG Evolution and Heterogeneity Working Group, Niall M. Corcoran, Tony Papenfuss, Christopher M. Hovens, Florian Markowetz, Geoff Macintyre, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.
Externí odkaz:
https://doaj.org/article/d5ec449112ae44a0b2a02b5a8b922643
Autor:
Lucy Vivash, Charles B. Malpas, Christian Meletis, Meghan Gollant, Dhamidhu Eratne, Qiao‐Xin Li, Stuart McDonald, William T. O'Brien, Amy Brodtmann, David Darby, Christopher Kyndt, Mark Walterfang, Christopher M. Hovens, Dennis Velakoulis, Terence J. O'Brien
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Sodium selenate increases tau dephosphorylation through protein phosphatase 2 activation. Here we report an open‐label Phase 1b study of sodium selenate as a disease‐modifying treatment for behavioral variant frontotemporal
Externí odkaz:
https://doaj.org/article/2208b7c2a982408199bac2e4e96fdce6
Autor:
Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, PCAWG Evolution and Heterogeneity Working Group, Niall M. Corcoran, Tony Papenfuss, Christopher M. Hovens, Florian Markowetz, Geoff Macintyre, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/34c7a655757d403eb57ca99726706619
Autor:
Patrick J. McCoy, Anthony J. Costello, Niall M. Corcoran, Christopher M. Hovens, Michael J. Clarkson
Publikováno v:
MethodsX, Vol 6, Iss , Pp 22-34 (2019)
DNA-fluorescence in situ hybridisation (DNA-FISH) allows visualisation of chromosome organisation and rearrangement. FISH probes are pools of short fluorescently labelled DNA fragments that are often produced from template plasmids that contain large
Externí odkaz:
https://doaj.org/article/315081ce01e54bff8ad9b9f56810a674
Autor:
Nigel C. Jones, Thanh Nguyen, Niall M. Corcoran, Dennis Velakoulis, Tracy Chen, Robert Grundy, Terence J. O'Brien, Christopher M. Hovens
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 897-901 (2012)
Tau hyperphosphorylation has been implicated in the pathogenesis of a variety of forms of human epilepsy. Here we investigated whether treatment with sodium selenate, a drug which reduces pathological hyperphosphorylated tau by enhancement of PP2A ac
Externí odkaz:
https://doaj.org/article/173fb7b6f3d74bd5a029b8d118b37fe7
Publikováno v:
BioTechniques, Vol 20, Iss 6, Pp 960-962 (1996)
Externí odkaz:
https://doaj.org/article/ff90cdae991d44f99b1ea782e71c4208
Autor:
Lucy Vivash, Dennis Velakoulis, Patrick Carney, Patrick Kwan, Leonid Churilov, Terence J O’Brien, Christopher M Hovens, Nicholas Lawn, Piero Perucca, Sandy R Shultz, John-Paul Nicolo, Charles Malpas, Manori Wijayath, David Reutens, Hannah Johns, Sara MacPhail, Pablo Casillas-Espinosa, Chris Tailby, Lisa Gillinder
Publikováno v:
BMJ Open, Vol 13, Iss 10 (2023)
Introduction Epilepsy is one of the most common neurological conditions worldwide. Despite many antiseizure medications (ASMs) being available, up to one-third of patients do not achieve seizure control. Preclinical studies have shown treatment with
Externí odkaz:
https://doaj.org/article/3fd64e9e8e8b4ff9b7e3d63e337655c5