Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Christopher M. Hovens"'
Autor:
Niranjan J. Sathianathen, Marc A. Furrer, Clancy J. Mulholland, Andreas Katsios, Christopher Soliman, Nathan Lawrentschuk, Justin S. Peters, Homi Zargar, Anthony J. Costello, Christopher M. Hovens, Conrad Bishop, Ranjit Rao, Raymond Tong, Daniel Steiner, Daniel Moon, Benjamin C. Thomas, Philip Dundee, Jose Antonio Rodriguez Calero, George N. Thalmann, Niall M. Corcoran
Publikováno v:
Cancers, Vol 16, Iss 1, p 123 (2023)
Lymphovascular invasion, whereby tumour cells or cell clusters are identified in the lumen of lymphatic or blood vessels, is thought to be an essential step in disease dissemination. It has been established as an independent negative prognostic indic
Externí odkaz:
https://doaj.org/article/ce7257a08eee4d469c67d36e0bcb426f
Autor:
Yangyi Zhang, Bethany K. Campbell, Stanley S. Stylli, Niall M. Corcoran, Christopher M. Hovens
Publikováno v:
Uro, Vol 2, Iss 2, Pp 74-92 (2022)
Advanced prostate cancers have a poor survival rate and a lack of effective treatment options. In order to broaden the available treatments, immunotherapies have been investigated. These include cancer vaccines, immune checkpoint inhibitors, chimeric
Externí odkaz:
https://doaj.org/article/263f8799ad8e4859b4614d2ddb36e925
Autor:
Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams, Anthony J. Costello, Paul J. Neeson, Bhupinder Pal, Nicholas D. Huntington, Niall M. Corcoran, Anthony T. Papenfuss, Christopher M. Hovens
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-18 (2021)
Abstract Background Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tumour microenvironment
Externí odkaz:
https://doaj.org/article/6df753fdc4cc463099e2cb3f0e220186
Autor:
Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, PCAWG Evolution and Heterogeneity Working Group, Niall M. Corcoran, Tony Papenfuss, Christopher M. Hovens, Florian Markowetz, Geoff Macintyre, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/34c7a655757d403eb57ca99726706619
Autor:
Lucy Vivash, Charles B. Malpas, Christian Meletis, Meghan Gollant, Dhamidhu Eratne, Qiao‐Xin Li, Stuart McDonald, William T. O'Brien, Amy Brodtmann, David Darby, Christopher Kyndt, Mark Walterfang, Christopher M. Hovens, Dennis Velakoulis, Terence J. O'Brien
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Sodium selenate increases tau dephosphorylation through protein phosphatase 2 activation. Here we report an open‐label Phase 1b study of sodium selenate as a disease‐modifying treatment for behavioral variant frontotemporal
Externí odkaz:
https://doaj.org/article/2208b7c2a982408199bac2e4e96fdce6
Autor:
Edmund Lau, Patrick McCoy, Fairleigh Reeves, Ken Chow, Michael Clarkson, Edmond M. Kwan, Kate Packwood, Helen Northen, Miao He, Zoya Kingsbury, Stefano Mangiola, Michael Kerger, Marc A. Furrer, Helen Crowe, Anthony J. Costello, David J. McBride, Mark T. Ross, Bernard Pope, Christopher M. Hovens, Niall M. Corcoran
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-11 (2020)
Abstract Background DNA originating from degenerate tumour cells can be detected in the circulation in many tumour types, where it can be used as a marker of disease burden as well as to monitor treatment response. Although circulating tumour DNA (ct
Externí odkaz:
https://doaj.org/article/dff3ff03bc4d479295f4bcd8450cf3d3
Autor:
Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, PCAWG Evolution and Heterogeneity Working Group, Niall M. Corcoran, Tony Papenfuss, Christopher M. Hovens, Florian Markowetz, Geoff Macintyre, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.
Externí odkaz:
https://doaj.org/article/d5ec449112ae44a0b2a02b5a8b922643
Publikováno v:
Cancers, Vol 14, Iss 19, p 4963 (2022)
Targeted therapies for cancers have improved primary tumor response rates, but concomitantly, brain metastases (BM) have become the most common brain tumors in adults and are associated with a dismal prognosis of generally less than 6 months, irrespe
Externí odkaz:
https://doaj.org/article/ab007f4ad123486397d21be61ddad66e
Autor:
Patrick J. McCoy, Anthony J. Costello, Niall M. Corcoran, Christopher M. Hovens, Michael J. Clarkson
Publikováno v:
MethodsX, Vol 6, Iss , Pp 22-34 (2019)
DNA-fluorescence in situ hybridisation (DNA-FISH) allows visualisation of chromosome organisation and rearrangement. FISH probes are pools of short fluorescently labelled DNA fragments that are often produced from template plasmids that contain large
Externí odkaz:
https://doaj.org/article/315081ce01e54bff8ad9b9f56810a674
Publikováno v:
Cancers, Vol 14, Iss 1, p 166 (2021)
Prostate cancer (PCa) is a hormone driven cancer, characterised by defects in androgen receptor signalling which drive the disease process. As such, androgen targeted therapies have been the mainstay for PCa treatment for over 70 years. High-risk PCa
Externí odkaz:
https://doaj.org/article/e0ec474003364962a2ce12604b00544b