Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christopher M. Hoffmann"'
Autor:
Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann, Taronish D. Dubash, Klara M. Giessler, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm, Claudia R. Ball
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the mechanisms regulating
Externí odkaz:
https://doaj.org/article/ba1aaeb46e174969b3e687ece0a945c4
Autor:
Claudia R Ball, Felix Oppel, Karl Roland Ehrenberg, Taronish D Dubash, Sebastian M Dieter, Christopher M Hoffmann, Ulrich Abel, Friederike Herbst, Moritz Koch, Jens Werner, Frank Bergmann, Naveed Ishaque, Manfred Schmidt, Christof von Kalle, Claudia Scholl, Stefan Fröhling, Benedikt Brors, Wilko Weichert, Jürgen Weitz, Hanno Glimm
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 918-932 (2017)
Abstract Although tumor‐initiating cell (TIC) self‐renewal has been postulated to be essential in progression and metastasis formation of human pancreatic adenocarcinoma (PDAC), clonal dynamics of TICs within PDAC tumors are yet unknown. Here, we
Externí odkaz:
https://doaj.org/article/806e5c3796d448e3a3f8956eba08fa15
Autor:
Filippo Rizzo, Diana Schaufler, Jens Panse, Matthias Scheffler, Kato Kambartel, Martin Metzenmacher, Judith Atz, Amin T. Turki, Christopher M. Hoffmann, Hannes Buchner, Mathias Hoiczyk, Daniel C. Christoph, Ivo Azeh
Publikováno v:
Future oncology 17(30), 3965-3976 (2021). doi:10.2217/fon-2021-0424
Future oncology 17(30), 3965-3976 (2021). doi:10.2217/fon-2021-0424
Published by Future Medicine Ltd, London
Published by Future Medicine Ltd, London
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68716ccd9695d9b11a957bafc27c4c0
https://pubmed.ncbi.nlm.nih.gov/34287064
https://pubmed.ncbi.nlm.nih.gov/34287064
Autor:
Konrad Kokowski, Andrea Schuler, Christopher M. Hoffmann, Justyna Rawluk, Stefan Krüger, Tobias Gaska, Martin Reck, Frank Griesinger, Eckart Laack, Joachim H. Ficker, Cornelius Kortsik, Stephan Budweiser, Harald Schäfer, W. M. Brückl
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: Lung cancer is a leading cause of cancer-related death in Germany and worldwide. Non-small cell lung cancer (NSCLC) comprises ~80% of lung cancer diagnoses; in White patients, around 10% of NSCLC cases are epidermal growth factor receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f7a8af0d8564f01870eba5fba09e65
https://doaj.org/article/ed0a49a21806468b8eeae86252f9ad54
https://doaj.org/article/ed0a49a21806468b8eeae86252f9ad54
Autor:
Benedikt Brors, Christof von Kalle, Stefan Frohling, Moritz Koch, Christopher M. Hoffmann, Ulrich Abel, Sebastian M. Dieter, Jürgen Weitz, Manfred G. Schmidt, Claudia R. Ball, Wilko Weichert, Felix Oppel, Frank Bergmann, Jens Werner, Claudia Scholl, Taronish D. Dubash, Karl Roland Ehrenberg, Hanno Glimm, Naveed Ishaque, Friederike Herbst
Publikováno v:
EMBO Molecular Medicine
Although tumor‐initiating cell (TIC) self‐renewal has been postulated to be essential in progression and metastasis formation of human pancreatic adenocarcinoma (PDAC), clonal dynamics of TICs within PDAC tumors are yet unknown. Here, we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ba0392a324d3e3cbda48a65fdd69c9
https://doi.org/10.15252/emmm.201607354
https://doi.org/10.15252/emmm.201607354
Autor:
Wilko Weichert, Mark Kriegsmann, Ulrike Heger, Felix Oppel, Jianpeng Gao, Benedikt Brors, Eva Maria Hartinger, Ava Oberlack, Erik R. Schulz, Taronish D. Dubash, Alexis Ulrich, K. Roland Ehrenberg, Sebastian M. Dieter, Martin Schneider, Sarah Weber, Hendrik Strakerjahn, Felix Lasitschka, Hanno Glimm, Klara M. Giessler, Nati Ha, Lino Möhrmann, Manfred Schmidt, Christopher M. Hoffmann, Christine Siegl, Oliver Strobel, Claudia R. Ball, Christof von Kalle
Publikováno v:
International Journal of Cancer. 140:1356-1363
Patient-derived cancer xenografts (PDX) are widely used to identify and evaluate novel therapeutic targets, and to test therapeutic approaches in preclinical mouse avatar trials. Despite their widespread use, potential caveats of PDX models remain co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10f03a2d426acb785b4ff4196e88b27e
https://doi.org/10.1002/ijc.30561
https://doi.org/10.1002/ijc.30561
Autor:
Taronish D. Dubash, Klara M. Giessler, Martin Schneider, Wiebke Werft, Claudia R. Ball, Wilko Weichert, Christopher M. Hoffmann, Friederike Herbst, Claudia Scholl, Manfred Schmidt, Axel Benner, Hanno Glimm, Sebastian M. Dieter, Sarah Weber, Thorsten Zenz, Felix Oppel, Jennifer Hüllein
Publikováno v:
Cancer Letters. 371:326-333
Within primary colorectal cancer (CRC) a subfraction of all tumor-initiating cells (TIC) drives long-term progression in serial xenotransplantation. It has been postulated that efficient maintenance of TIC activity in vitro requires serum-free sphero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deecc9bdc87fc33066ce45968227e348
https://doi.org/10.1016/j.canlet.2015.11.037
https://doi.org/10.1016/j.canlet.2015.11.037
Autor:
Stephan Budweiser, Tobias Gaska, Martin Reck, Harald Schäfer, Andrea Schueler, Wolfgang M. Brueckl, Eckardt Laack, Stefan Krüger, Justyna Rawluk, Konrad Kokowski, Christopher M. Hoffmann, Cornelius Kortsik
Publikováno v:
Journal of Clinical Oncology. 38:e21636-e21636
e21636 Background: Afatinib is an irreversible ErbB family blocker, which is approved for the treatment of advanced non-small cell lung cancer (NSCLC) patients with activating EGFR mutations. Here we report the final results of the prospective non-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc55f223118680ee050d6c5c71d987aa
https://doi.org/10.1200/jco.2020.38.15_suppl.e21636
https://doi.org/10.1200/jco.2020.38.15_suppl.e21636
Publikováno v:
Journal of Thoracic Oncology. 14:S670-S671
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9676deb4f8d837ef7e9c638daf06a4f
https://doi.org/10.1016/j.jtho.2019.08.1422
https://doi.org/10.1016/j.jtho.2019.08.1422
Autor:
Raffaele Fronza, Claudia R. Ball, Benedikt Brors, Claudia Scholl, Klara M. Giessler, Roland Eils, Nagarajan Paramasivam, Wilko Weichert, Matthias Schlesner, Daniel Huebschmann, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm, Stefan Fröhling, Manfred Schmidt, Christof von Kalle, Ivo Buchhalter, Alexis Ulrich, Martin Schneider, Sarah Weber, Christopher M. Hoffmann, Taronish D. Dubash, Gnana Prakash Balasubramanian, Kortine Kleinheinz, Christine Siegl
Publikováno v:
The Journal of Experimental Medicine
Combining high-coverage whole-genome sequencing with functional analyses, Giessler et al. demonstrate that tumor initiation and long-term tumor formation in human colorectal cancer are driven by multiple genomic subclones and that the functional hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cfe1596c12ffc3eab0368b82695027
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/79224
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/79224
