Výsledky vyhledávání - "Christopher M. Fanger"

Akademický článek

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice.

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0191225 (2018)

Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel canonical subfamily (TRPC) members 4 and 5 are non-selective cation channels highly expressed in

Externí odkaz: https://doaj.org/article/d155ef5931834a199fead5964ba61d05

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Akademický článek

MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit.

Autor: Robert A Volkmann, Christopher M Fanger, David R Anderson, Venkata Ramana Sirivolu, Kathy Paschetto, Earl Gordon, Caterina Virginio, Melanie Gleyzes, Bruno Buisson, Esther Steidl, Susanna B Mierau, Michela Fagiolini, Frank S Menniti

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148129 (2016)

GluN2A is the most abundant of the GluN2 NMDA receptor subunits in the mammalian CNS. Physiological and genetic evidence implicate GluN2A-containing receptors in susceptibility to autism, schizophrenia, childhood epilepsy and neurodevelopmental disor

Externí odkaz: https://doaj.org/article/2735bce216d245b2951e2be95a93cd11

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Calcium-activated Potassium Channels Sustain Calcium Signaling in T Lymphocytes

Autor: Amber L. Neben, Christopher M. Fanger, Joaquin Campos Rosa, C. Robin Ganellin, K. George Chandy, Michael D. Cahalan, Heike Rauer, Heiko Rauer, Heike Wulff, Mark J. Miller

Publikováno v: Journal of Biological Chemistry. 276:12249-12256

To maintain Ca2+ entry during T lymphocyte activation, a balancing efflux of cations is necessary. Using three approaches, we demonstrate that this cation efflux is mediated by Ca2+-activated K+ (KCa) channels, hSKCa2 in the human leukemic T cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a55db6e7f6092c822c4cd9725699de43
https://doi.org/10.1074/jbc.m011342200

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Single Channel Properties and Regulated Expression of Ca2+ Release-Activated Ca2+ (Crac) Channels in Human T Cells

Autor: Alla F. Fomina, Christopher M. Fanger, Michael D. Cahalan, J. Ashot Kozak

Publikováno v: The Journal of Cell Biology
Fomina, AF; Fanger, CM; Kozak, JA; & Cahalan, MD. (2000). Single channel properties and regulated expression of Ca2+ release-activated Ca2+ (CRAC) channels in human T cells. Journal of Cell Biology, 150(6), 1435-1444. doi: 10.1083/jcb.150.6.1435. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9x79w908

Although the crucial role of Ca(2+) influx in lymphocyte activation has been well documented, little is known about the properties or expression levels of Ca(2+) channels in normal human T lymphocytes. The use of Na(+) as the permeant ion in divalent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238195528949ad2ea5210ae6020be4f4
https://doi.org/10.1083/jcb.150.6.1435

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Differential Ca2+ Influx, KCa Channel Activity, and Ca2+ Clearance Distinguish Th1 and Th2 Lymphocytes

Autor: Christopher M. Fanger, Amber L. Neben, Michael D. Cahalan

Publikováno v: The Journal of Immunology. 164:1153-1160

In Th1 and Th2 lymphocytes, activation begins with identical stimuli but results in the production of different cytokines. The expression of some cytokine genes is differentially induced according to the amplitude and pattern of Ca2+ signaling. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9006b492c652c1ebab49db0dfe556ce
https://doi.org/10.4049/jimmunol.164.3.1153

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Vanadate Induces Calcium Signaling, Ca2+ Release-Activated Ca2+ Channel Activation, and Gene Expression in T Lymphocytes and RBL-2H3 Mast Cells Via Thiol Oxidation

Autor: Michael D. Cahalan, Christopher M. Fanger, George R. Ehring, Hubert H. Kerschbaum, Claudia Eder, Heiko Rauer

Publikováno v: The Journal of Immunology. 164:679-687

Using ratiometric Ca2+ imaging and patch-clamp measurement of Ca2+ channel activity, we investigated Ca2+ signaling induced by vanadium compounds in Jurkat T lymphocytes and rat basophilic leukemia cells. In the presence of external Ca2+, vanadium co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278b0be15b72a670dd7e0690ba5b1a6a
https://doi.org/10.4049/jimmunol.164.2.679

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Calmodulin Mediates Calcium-dependent Activation of the Intermediate Conductance KCa Channel,IKCa1

Autor: K. George Chandy, Christopher M. Fanger, Naomi J. Logsdon, K. Kalman, Heiko Rauer, Sanjiv Ghanshani, Jianming Zhou, Jayashree Aiyar, Michael D. Cahalan, Kathy Beckingham

Publikováno v: Journal of Biological Chemistry. 274:5746-5754

Small and intermediate conductance Ca2+-activated K+ channels play a crucial role in hyperpolarizing the membrane potential of excitable and nonexcitable cells. These channels are exquisitely sensitive to cytoplasmic Ca2+, yet their protein-coding re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301498eef42abaeb2702fea0ee395c5c
https://doi.org/10.1074/jbc.274.9.5746

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A Nongenomic Mechanism for Progesterone-mediated Immunosuppression: Inhibition of K+ Channels, Ca2+ Signaling, and Gene Expression in T Lymphocytes

Autor: AL Neben, Hubert H. Kerschbaum, PA Negulescu, Cahalan, George R. Ehring, RM Khoury, Christopher M. Fanger, C Eder

Publikováno v: The Journal of Experimental Medicine
Ehring, GR; Kerschbaum, HH; Eder, C; Neben, AL; Fanger, CM; Khoury, RM; et al.(1998). A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. Journal of Experimental Medicine, 188(9), 1593-1602. doi: 10.1084/jem.188.9.1593. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9vp6q27p

The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6500b4a1790c99f59e0b5c74153563b
http://europepmc.org/articles/PMC2212508

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Function Follows Form: The Role of Store-Operated Calcium Channels in T-Cell Activation

Autor: Markus Hoth, Christopher M. Fanger, Ricardo E. Dolmetsch, Adam Zweifach, Richard S. Lewis

Publikováno v: Cellular Physiology and Biochemistry. 7:203-218

In T lymphocytes and most other nonexcitable cells, store-operated channels (SOCs) are activated through an unknown mechanism following depletion of intracellular Ca2+ stores. Several lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcd229a0c608367f940b0dbd3a1c526f
https://doi.org/10.1159/000154875

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Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels

Autor: Markus Hoth, Christopher M. Fanger, Gerald R. Crabtree, Richard S. Lewis

Publikováno v: The Journal of Cell Biology

Prolonged Ca2+ influx is an essential signal for the activation of T lymphocytes by antigen. This influx is thought to occur through highly selective Ca2+ release-activated Ca2+ (CRAC) channels that are activated by the depletion of intracellular Ca2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9d26e45cd3173e31263022b3b891fb
https://doi.org/10.1083/jcb.131.3.655

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