Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Christopher M. Dekaney"'
Autor:
Breanna J. Sheahan, Ally N. Freeman, Theresa M. Keeley, Linda C. Samuelson, Jatin Roper, Stephanie Hasapis, Chang-Lung Lee, Christopher M. Dekaney
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 119-140 (2021)
Background & Aims: aISCs (aISCs) are sensitive to acute insults including chemotherapy and irradiation. Regeneration after aISC depletion has primarily been explored in irradiation (IR). However, the cellular origin of epithelial regeneration after d
Externí odkaz:
https://doaj.org/article/1fdc8017627a4936aaa507c1c7059457
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1239-1250 (2021)
Paneth cells are professional secretory cells that classically play a role in the innate immune system by secreting antimicrobial factors into the lumen to control enteric bacteria. In this role, Paneth cells are able to sense cues from luminal bacte
Externí odkaz:
https://doaj.org/article/ed40090c79c241a4877cd9d377ecc7a9
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Enteric bacteria and/or their products are necessary for doxorubicin (DXR)-induced small intestine mucosal damage. While DXR does not induce gross loss of epithelium, others have shown elevated serum endotoxin after DXR administration. Howev
Externí odkaz:
https://doaj.org/article/78603ac7a081400ca719e9c2c2854856
Autor:
Ajeet P. Singh, Yu-Han Hung, Michael T. Shanahan, Matt Kanke, Alessandro Bonfini, Michael K. Dame, Mandy Biraud, Bailey C.E. Peck, Oyebola O. Oyesola, John M. Freund, Rebecca L. Cubitt, Ennessa G. Curry, Liara M. Gonzalez, Gavin A. Bewick, Elia D. Tait-Wojno, Natasza A. Kurpios, Shengli Ding, Jason R. Spence, Christopher M. Dekaney, Nicolas Buchon, Praveen Sethupathy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 447-464 (2020)
Background & Aims: The enteroendocrine cell (EEC) lineage is important for intestinal homeostasis. It was recently shown that EEC progenitors contribute to intestinal epithelial growth and renewal, but the underlying mechanisms remain poorly understo
Externí odkaz:
https://doaj.org/article/e87a118dfef14cd1be95f0a2ba116a82
Autor:
Jennifer C. Jones, Constance D. Brindley, Nicholas H. Elder, Martin G. Myers, Jr., Michael W. Rajala, Christopher M. Dekaney, Eoin N. McNamee, Mark R. Frey, Noah F. Shroyer, Peter J. Dempsey
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 533-554 (2019)
Background & Aims: Loss of leucine-rich repeat-containing G-protein–coupled receptor 5–positive crypt base columnar cells provides permissive conditions for different facultative stem cell populations to dedifferentiate and repopulate the stem ce
Externí odkaz:
https://doaj.org/article/b50cd1ae4ab4413abe5adbd5f3da1205
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 549-560 (2019)
Background: Paneth cells are professional secretory cells found within the small intestinal crypt epithelium. Although their role as part of the innate immune complex providing antimicrobial secretory products is well-known, the mechanisms that contr
Externí odkaz:
https://doaj.org/article/c126cf32b104410ab67994b86b9f1d9a
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 1, Pp 121-122 (2018)
Externí odkaz:
https://doaj.org/article/561e7f099e1a4e84b2ad8f1dbb67945a
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Enteric bacteria and/or their products are necessary for doxorubicin (DXR)-induced small intestine mucosal damage. While DXR does not induce gross loss of epithelium, others have shown elevated serum endotoxin after DXR administration. However, the m
Publikováno v:
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes, Vol 14, Iss 1 (2022)
article-version (VoR) Version of Record
Gut Microbes, Vol 14, Iss 1 (2022)
Acute intestinal mucositis is a common off-target effect of chemotherapy, leading to co-morbidities such as vomiting, diarrhea, sepsis, and death. We previously demonstrated that the presence of enteric bacteria modulates the extent of jejunal epithe
Autor:
Elia D. Tait-Wojno, Dipak Kumar Sahoo, Ajeet Singh, Matt Kanke, Christopher M. Dekaney, Natasza A. Kurpios, Rebecca L. Cubitt, Bailey C.E. Peck, Oyebola O. Oyesola, Josca E. Cortes, Shengli Ding, Huiyu Gong, Karin Allenspach, Michael J. Shanahan, Kieran Koch-Laskowski, Breanna Sheahan, Mandy Biraud, Steven J. McElroy, Jonathan P. Mochel, Praveen Sethupathy, Yu-Han Hung, Jakob von Moltke
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
MicroRNA-mediated regulation is critical for the proper development and function of the small intestinal (SI) epithelium. However, it is not known which microRNAs are expressed in each of the cell types of the SI epithelium. To bridge this important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bd0f58b3b3ea78fe704e27c63d0d47
https://europepmc.org/articles/PMC8887887/
https://europepmc.org/articles/PMC8887887/