Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christopher M. Bruns"'
Autor:
Christopher M. Bruns, Sean D. Murphy, Jayaram Chandrashekar, Regina Blake, Patrick Edson, Donald J. Olbris, Zhuhao Wu, Monet Weldon, Tiago Ferreira, Joshua T. Dudmann, Johan Winnubst, Amina Zafar, Wyatt Korff, Ben J. Arthur, Michael N. Economo, Adam W. Hantman, Daniel Ramirez, Karel Svoboda, Charles R. Gerfen, Bruno Dos Santos, Erhan Bas, Scott M. Sternson, David Schauder, Nelson Spruston, Cameron Arshadi, Konrad Rokicki, David G. Ackerman, Perry Baldwin, Ahmad Elsayed, Mashtura Hasan
Publikováno v:
Cell
SummaryNeuronal cell types are the nodes of neural circuits that determine the flow of information within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides an essential descriptor of cell type and reveals how individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53c99e54ebb08461de4b653628bf534
https://europepmc.org/articles/PMC6754285/
https://europepmc.org/articles/PMC6754285/
Autor:
Vivek Jayaraman, David Schauder, Melanie A. Basnak, Hannah Haberkern, Christopher M. Bruns, Mark Bolstad, Biafra Ahanonu, Jeremy D. Cohen
A navigating animal’s sensory experience is shaped not just by its surroundings, but by its movements within them, which in turn are influenced by its past experiences. Studying the intertwined roles of sensation, experience and directed action in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c6841e0f9755a9834f89d6eeb60912
Autor:
David Schauder, Vivek Jayaraman, Christopher M. Bruns, Hannah Haberkern, Melanie A. Basnak, Jeremy D. Cohen, Biafra Ahanonu, Mark Bolstad
Publikováno v:
Current Biology. 29:1647-1659.e8
Summary Studying the intertwined roles of sensation, experience, and directed action in navigation has been facilitated by the development of virtual reality (VR) environments for head-fixed animals, allowing for quantitative measurements of behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030ad327f6b78f5f71771f6e41f2a919
https://doi.org/10.1016/j.cub.2019.04.033
https://doi.org/10.1016/j.cub.2019.04.033
Autor:
John D. Chodera, Vijay S. Pande, Mike Houston, Tony Tye, Michael R. Shirts, Randall J. Radmer, Christoph Klein, Kyle A. Beauchamp, Christopher M. Bruns, Timo Stich, Joy P. Ku, Mark S. Friedrichs, Thomas J. Lane, Diwakar Shukla, Peter Eastman, Lee-Ping Wang
Publikováno v:
Journal of Chemical Theory and Computation. 9:461-469
OpenMM is a software toolkit for performing molecular simulations on a range of high performance computing architectures. It is based on a layered architecture: the lower layers function as a reusable library that can be invoked by any application, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5db8221d8278e3e1f7bf7314094751
https://doi.org/10.1021/ct300857j
https://doi.org/10.1021/ct300857j
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 8:1247-1257
Modeling the structure and dynamics of large macromolecules remains a critical challenge. Molecular dynamics (MD) simulations are expensive because they model every atom independently, and are difficult to combine with experimentally derived knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f7be2518eb5e4e32ce1a8795d56657
https://doi.org/10.1109/tcbb.2010.104
https://doi.org/10.1109/tcbb.2010.104
Autor:
Adam L. Beberg, Christopher M. Bruns, Mark S. Friedrichs, Vishal Vaidyanathan, Daniel L. Ensign, Scott LeGrand, Peter Eastman, Vijay S. Pande, Mike Houston
Publikováno v:
Journal of Computational Chemistry. 30:864-872
We describe a complete implementation of all-atom protein molecular dynamics running entirely on a graphics processing unit (GPU), including all standard force field terms, integration, constraints, and implicit solvent. We discuss the design of our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1321f554fe4d81921513d1cfb963171
https://doi.org/10.1002/jcc.21209
https://doi.org/10.1002/jcc.21209
Publikováno v:
Protein Engineering, Design and Selection. 15:827-834
By the introduction of 10 site-specific mutations in the dimer interface of human glutathione transferase P1-1 (GSTP1-1), a stable monomeric protein variant, GSTP1, was obtained. The monomer had lost the catalytic activity but retained the affinity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06e33d0484866994076a164e7b2873d
https://doi.org/10.1093/protein/15.10.827
https://doi.org/10.1093/protein/15.10.827
Autor:
Damon S. Anderson, Pamela A. Williams, Andrew J. Nowalk, Timothy A. Mietzner, Christopher M. Bruns, Kevin G. Vaughan, Duncan E. Mcree
Publikováno v:
Biochemistry. 40:15631-15637
The crystal structure of the iron-free (apo) form of the Haemophilus influenzae Fe(3+)-binding protein (hFbp) has been determined to 1.75 A resolution. Information from this structure complements that derived from the holo structure with respect to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3784c79fc2fd326a0c66eb902edade66
https://doi.org/10.1021/bi0156759
https://doi.org/10.1021/bi0156759
Publikováno v:
Journal of Molecular Biology. 288:427-439
The oxidation of lipids and cell membranes generates cytotoxic compounds implicated in the etiology of aging, cancer, atherosclerosis, neurodegenerative diseases, and other illnesses. Glutathione transferase (GST) A4-4 is a key component in the defen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d8379eaabacdeb15f8f473d2cd3c7e
https://doi.org/10.1006/jmbi.1999.2697
https://doi.org/10.1006/jmbi.1999.2697
Autor:
Andrew S. Arvai, Christopher M. Bruns, Andrew J. Nowalk, Michele A. McTigue, Duncan E. McRee, Kevin G. Vaughan, Timothy A. Mietzner
Publikováno v:
Nature Structural & Molecular Biology. 4:919-924
The first crystal structure of the iron-transporter ferric ion-binding protein from Haemophilus influenzae (hFBP), at 1.6 A resolution, reveals the structural basis for iron uptake and transport required by several important bacterial pathogens. Para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcc93e18c485305afc2d5de47626dfc
https://doi.org/10.1038/nsb1197-919
https://doi.org/10.1038/nsb1197-919