Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christopher M. Brackett"'
Autor:
Margaret J. Hilton, Christopher M. Brackett, Brandon Q. Mercado, Brian S. J. Blagg, Scott J. Miller
Publikováno v:
ACS Central Science, Vol 6, Iss 3, Pp 426-435 (2020)
Externí odkaz:
https://doaj.org/article/986b843fd1014d7e9f8d040931a52f63
Publikováno v:
Medicinal research reviewsREFERENCES. 42(6)
The 94 kDa molecular chaperone, glucose-regulated protein 94 (Grp94), has garnered interest during the last decade due to its direct association with endoplasmic reticulum (ER) stress and disease. Grp94 belongs to the Hsp90 family of molecular chaper
Autor:
Kenneth A. Jacobson, Dilip K. Tosh, Zhan-Guo Gao, Monimoy Banerjee, Brian S. J. Blagg, Christopher M. Brackett, Young-Hwan Jung
Publikováno v:
ACS Medicinal Chemistry Letters. 12:373-379
The heat shock protein 90 kDa (Hsp90) family of chaperones is highly sought-after for the treatment of cancer and neurodegenerative diseases. Glucose regulated protein 94 (Grp94) is the endoplasmic...
Publikováno v:
ACS Med Chem Lett
[Image: see text] SUMOylation has emerged as an important post-translational modification that has been shown to modulate protein activity associated with various signaling pathways, and consequently, it has emerged as an important therapeutic target
Autor:
Brian S. J. Blagg, Margaret J. Hilton, Brandon Q. Mercado, Christopher M. Brackett, Scott J. Miller
Publikováno v:
ACS Central Science, Vol 6, Iss 3, Pp 426-435 (2020)
ACS Central Science
ACS Central Science
Catalytic, selective modifications of natural products can be a fertile platform for not only unveiling new natural product analogues with altered biological activity, but also for revealing new reactivity and selectivity hierarchies for embedded fun
Publikováno v:
The FASEB Journal. 35
Autor:
Bradley M. Minrovic, Sarah E Harrill, Catherine M. Nguyen, Robert K. Ernst, Sara E. Martin, Roberta J. Melander, Colin Manoil, Christian Melander, Courtney E. Chandler, Christopher M. Brackett, Alison J. Scott
Publikováno v:
ACS Infectious Diseases. 5:1223-1230
In 2016, the World Health Organization deemed antibiotic resistance one of the biggest threats to global health, food security, and development. The need for new methods to combat infections caused by antibiotic resistant pathogens will require a var
Autor:
Dilip K, Tosh, Christopher M, Brackett, Young-Hwan, Jung, Zhan-Guo, Gao, Monimoy, Banerjee, Brian S J, Blagg, Kenneth A, Jacobson
Publikováno v:
ACS Med Chem Lett
[Image: see text] The heat shock protein 90 kDa (Hsp90) family of chaperones is highly sought-after for the treatment of cancer and neurodegenerative diseases. Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum localized isoform that i
Publikováno v:
Curr Med Chem
SUMOylation has emerged as an important post-translational modification that involves the covalent attachment of the Small Ubiquitin-like Modifier (SUMO) polypeptide to a lysine residue of a target protein. The enzymatic pathway of SUMOylation is ver
Autor:
Sara E, Martin, Roberta J, Melander, Christopher M, Brackett, Alison J, Scott, Courtney E, Chandler, Catherine M, Nguyen, Bradley M, Minrovic, Sarah E, Harrill, Robert K, Ernst, Colin, Manoil, Christian, Melander
Publikováno v:
ACS Infect Dis
In 2016, the World Health Organization deemed antibiotic resistance one of the biggest threats to global health, food security, and development. The need for new methods to combat infections caused by antibiotic resistant pathogens will require a var