Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Christopher M. Allan"'
Autor:
John G. Luz, Anne P. Beigneux, DeeAnn K. Asamoto, Cuiwen He, Wenxin Song, Christopher M. Allan, Jazmin Morales, Yiping Tu, Adam Kwok, Thomas Cottle, Muthuraman Meiyappan, Loren G. Fong, Judy E. Kim, Michael Ploug, Stephen G. Young, Gabriel Birrane
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 10, Pp 1347-1359 (2020)
For three decades, the LPL–specific monoclonal antibody 5D2 has been used to investigate LPL structure/function and intravascular lipolysis. 5D2 has been used to measure LPL levels, block the triglyceride hydrolase activity of LPL, and prevent the
Externí odkaz:
https://doaj.org/article/a080c819825b4d84b63608de28505ec2
Autor:
Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Jazmin E. Morales, Eniko Sajti, Ty D. Troutman, Thomas L. Saunders, Darren A. Cusanovich, Anne P. Beigneux, Casey E. Romanoski, Loren G. Fong, Stephen G. Young
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 869-879 (2019)
Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within t
Externí odkaz:
https://doaj.org/article/24c19b72c23b4571b22124accec34bdf
Autor:
Mikael Larsson, Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Rosemary L. Walzem, Anne P. Beigneux, Stephen G. Young, Loren G. Fong
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 4, Pp 706-713 (2018)
Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces and transports it to the capillary lumen. In Gpihbp1−/− mice, LPL remains stranded i
Externí odkaz:
https://doaj.org/article/569656b46a0e4a599c457cb73d1d2ee4
Autor:
Mikael Larsson, Christopher M. Allan, Rachel S. Jung, Patrick J. Heizer, Anne P. Beigneux, Stephen G. Young, Loren G. Fong
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 9, Pp 1893-1902 (2017)
ApoC-III is often assumed to retard the intravascular processing of triglyceride-rich lipoproteins (TRLs) by inhibiting LPL, but that view is based largely on studies of free LPL. We now recognize that intravascular LPL is neither free nor loosely bo
Externí odkaz:
https://doaj.org/article/da10f122d15a40adafea921b2e4f8132
Autor:
Christopher M. Allan, Cris J. Jung, Mikael Larsson, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Tiffany Ly P. Dang, Rachel S. Jung, Anne P. Beigneux, Pieter J. de Jong, Loren G. Fong, Stephen G. Young
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 7, Pp 1453-1461 (2017)
Mutation of conserved cysteines in proteins of the Ly6 family cause human disease—chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1) and paroxysmal nocturnal hemoglobinuria in the case of CD59. A mu
Externí odkaz:
https://doaj.org/article/a2e86bfa1c6e411aac0c3ca83c2b4f34
Autor:
Xuchen Hu, Mark W. Sleeman, Kazuya Miyashita, MacRae F. Linton, Christopher M. Allan, Cuiwen He, Mikael Larsson, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Alaleh Mapar, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 208-215 (2017)
GPIHBP1, an endothelial cell protein, binds LPL in the interstitial spaces and shuttles it to its site of action inside blood vessels. For years, studies of human GPIHBP1 have been hampered by an absence of useful antibodies. We reasoned that monoclo
Externí odkaz:
https://doaj.org/article/2cd466d9dd7b46b5858c18eb7905f80f
Autor:
Christopher M. Allan, Mikael Larsson, Rachel S. Jung, Michael Ploug, André Bensadoun, Anne P. Beigneux, Loren G. Fong, Stephen G. Young
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 216-225 (2017)
In mice lacking glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1), the LPL secreted by adipocytes and myocytes remains bound to heparan sulfate proteoglycans (HSPGs) on all cells within tissues. That observati
Externí odkaz:
https://doaj.org/article/2aa0556bd4d5433e890febd8867a19a7
Autor:
Christopher M. Allan, Mikael Larsson, Xuchen Hu, Cuiwen He, Rachel S. Jung, Alaleh Mapar, Constance Voss, Kazuya Miyashita, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, André Bensadoun, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 10, Pp 1889-1898 (2016)
LPL contains two principal domains: an amino-terminal catalytic domain (residues 1–297) and a carboxyl-terminal domain (residues 298–448) that is important for binding lipids and binding glycosylphosphatidylinositol-anchored high density lipoprot
Externí odkaz:
https://doaj.org/article/ac99a4b067b747f9917164d4c2dcfb51
Autor:
Cuiwen H. He, Dylan S. Black, Christopher M. Allan, Brigitte Meunier, Shamima Rahman, Catherine F. Clarke
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Coq9 is required for the stability of a mitochondrial multi-subunit complex, termed the CoQ-synthome, and the deamination step of Q intermediates that derive from para-aminobenzoic acid (pABA) in yeast. In human, mutations in the COQ9 gene cause neon
Externí odkaz:
https://doaj.org/article/a552c09530a542879d8354bc753a4d65
Autor:
Xuchen Hu, Ken Matsumoto, Rachel S Jung, Thomas A Weston, Patrick J Heizer, Cuiwen He, Norma P Sandoval, Christopher M Allan, Yiping Tu, Harry V Vinters, Linda M Liau, Rochelle M Ellison, Jazmin E Morales, Lynn J Baufeld, Nicholas A Bayley, Liqun He, Christer Betsholtz, Anne P Beigneux, David A Nathanson, Holger Gerhardt, Stephen G Young, Loren G Fong, Haibo Jiang
Publikováno v:
eLife, Vol 8 (2019)
GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoprotei
Externí odkaz:
https://doaj.org/article/c9e3de5bd1f74f16b0b5035d702b97d3