Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christopher M. Acker"'
Autor:
Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau prot
Externí odkaz:
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Christopher M Acker, Peter Davies, Philippe Marambaud
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 841-849 (2016)
Abstract Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in animal models, but advers
Externí odkaz:
https://doaj.org/article/84d5ac9f3e794abe8f2434556bbc913a
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135774 (2015)
Recent work from our lab and few others have strongly suggested that immunotherapy could be an effective means of preventing the development of tau accumulation in JNPL3 transgenic mice, carrying the human P301L mutation. The aim of this study was to
Externí odkaz:
https://doaj.org/article/7437dd4ead534e2db982ef68cf149a4c
Autor:
Peter Davies, Scott Ferguson, Gogce Crynen, Benoit Mouzon, Christopher M. Acker, Corbin Bachmeier, Michael Mullan, William Stewart, Joseph O. Ojo, Fiona Crawford
Publikováno v:
Journal of Neurotrauma. 36:576-588
Tau pathology associated with chronic traumatic encephalopathy has been documented in the brains of individuals with a history of repetitive mild traumatic brain injury (r-mTBI). At this stage, the pathobiological role of tau in r-mTBI has not been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657e44c44cf8fda7aa82d7943be6f307
https://doi.org/10.1089/neu.2018.5720
https://doi.org/10.1089/neu.2018.5720
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62402 (2013)
The use of antibodies to treat neurodegenerative diseases has undergone rapid development in the past decade. To date, immunotherapeutic approaches to Alzheimer's disease have mostly targeted amyloid beta as it is a secreted protein that can be found
Externí odkaz:
https://doaj.org/article/0a3feb91debe414bad608e6461a21d08
Autor:
Peter Davies, Michael Mullan, Benoit Mouzon, Ghania Ait-Ghezala, Daniel Paris, William Stewart, Joseph O. Ojo, Corbin Bachmeier, Fiona Crawford, Christopher M. Acker, Gogce Crynen, Scott Ferguson
Publikováno v:
Annals of Clinical and Translational Neurology
Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE). To date, preclinical studies largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b99cc21fa5e765aa49c402554b2bcfb
https://doi.org/10.1002/acn3.510
https://doi.org/10.1002/acn3.510
Autor:
Fiona Crawford, Michael J. Mullan, Joseph-Olubunmi Ojo, Benoit Mouzon, Corbin Bachmeier, William Stewart, Christopher M. Acker, Austin Ferro, Peter Davies, Gogce Crynen
Publikováno v:
Annals of Neurology. 75:241-254
Objective: Traumatic brain injury (TBI) is a recognized risk factor for later development of neurodegenerative disease. However, the mechanisms contributing to neurodegeneration following TBI remain obscure. Methods: In this study, we have utilized a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31453e81e576dac84b59940e7500b927
https://doi.org/10.1002/ana.24064
https://doi.org/10.1002/ana.24064
Publikováno v:
Journal of Alzheimer's Disease. 25:119-133
Several immunocytochemical studies have revealed that Abelson tyrosine kinase (c-Abl) is associated with both neuritic plaques and neurofibrillary tangles in the brains of patients with Alzheimer’s disease (AD). Additionally, c-Abl has been shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e528579f6a2c99fb17aba2dc4f8b4a5c
https://doi.org/10.3233/jad-2011-102025
https://doi.org/10.3233/jad-2011-102025
Publikováno v:
Journal of Alzheimer's Disease. 19:721-733
Tau is a microtubule-associated protein and a main component of neurofibrillary tangles, one of the pathologic hallmarks of Alzheimer’s disease. The paired helical filaments (PHF) that comprise neurofibrillary tangles contain an abnormally hyperpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b483c312cf73e1d09bb8708e5aefddec
https://doi.org/10.3233/jad-2010-1271
https://doi.org/10.3233/jad-2010-1271
Autor:
Giuseppe Terracina, Peter Davies, Stefanie K. Forest, Joel B. Schachter, Xiaohai Wang, Cristina d'Abramo, Christopher M. Acker
Publikováno v:
Neurobiology of aging. 37
In the attempt to elucidate if the "peripheral sink hypothesis" could be a potential mechanism of action for tau removal in passive immunotherapy experiments, we have examined tau levels in serum of chronically injected JNPL3 and Tg4510 transgenic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc158d79f650330acaec85ed60c831ae
https://pubmed.ncbi.nlm.nih.gov/26508157
https://pubmed.ncbi.nlm.nih.gov/26508157