Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christopher M. Acker"'
Autor:
Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau prot
Externí odkaz:
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Peter Davies, Scott Ferguson, Gogce Crynen, Benoit Mouzon, Christopher M. Acker, Corbin Bachmeier, Michael Mullan, William Stewart, Joseph O. Ojo, Fiona Crawford
Publikováno v:
Journal of Neurotrauma. 36:576-588
Tau pathology associated with chronic traumatic encephalopathy has been documented in the brains of individuals with a history of repetitive mild traumatic brain injury (r-mTBI). At this stage, the pathobiological role of tau in r-mTBI has not been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657e44c44cf8fda7aa82d7943be6f307
https://doi.org/10.1089/neu.2018.5720
https://doi.org/10.1089/neu.2018.5720
Autor:
Peter Davies, Michael Mullan, Benoit Mouzon, Ghania Ait-Ghezala, Daniel Paris, William Stewart, Joseph O. Ojo, Corbin Bachmeier, Fiona Crawford, Christopher M. Acker, Gogce Crynen, Scott Ferguson
Publikováno v:
Annals of Clinical and Translational Neurology
Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE). To date, preclinical studies largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b99cc21fa5e765aa49c402554b2bcfb
https://doi.org/10.1002/acn3.510
https://doi.org/10.1002/acn3.510
Autor:
Fiona Crawford, Michael J. Mullan, Joseph-Olubunmi Ojo, Benoit Mouzon, Corbin Bachmeier, William Stewart, Christopher M. Acker, Austin Ferro, Peter Davies, Gogce Crynen
Publikováno v:
Annals of Neurology. 75:241-254
Objective: Traumatic brain injury (TBI) is a recognized risk factor for later development of neurodegenerative disease. However, the mechanisms contributing to neurodegeneration following TBI remain obscure. Methods: In this study, we have utilized a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31453e81e576dac84b59940e7500b927
https://doi.org/10.1002/ana.24064
https://doi.org/10.1002/ana.24064
Autor:
Valérie Vingtdeux, Philippe Marambaud, Peter Davies, Pallavi Chandakkar, Christopher M. Acker, Haitian Zhao
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 841-849 (2016)
Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in animal models but adverse effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c394e7f109166ebc840780e50dc42cc
Publikováno v:
Journal of Alzheimer's Disease. 25:119-133
Several immunocytochemical studies have revealed that Abelson tyrosine kinase (c-Abl) is associated with both neuritic plaques and neurofibrillary tangles in the brains of patients with Alzheimer’s disease (AD). Additionally, c-Abl has been shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e528579f6a2c99fb17aba2dc4f8b4a5c
https://doi.org/10.3233/jad-2011-102025
https://doi.org/10.3233/jad-2011-102025
Publikováno v:
Journal of Alzheimer's Disease. 19:721-733
Tau is a microtubule-associated protein and a main component of neurofibrillary tangles, one of the pathologic hallmarks of Alzheimer’s disease. The paired helical filaments (PHF) that comprise neurofibrillary tangles contain an abnormally hyperpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b483c312cf73e1d09bb8708e5aefddec
https://doi.org/10.3233/jad-2010-1271
https://doi.org/10.3233/jad-2010-1271
Autor:
Giuseppe Terracina, Peter Davies, Stefanie K. Forest, Joel B. Schachter, Xiaohai Wang, Cristina d'Abramo, Christopher M. Acker
Publikováno v:
Neurobiology of aging. 37
In the attempt to elucidate if the "peripheral sink hypothesis" could be a potential mechanism of action for tau removal in passive immunotherapy experiments, we have examined tau levels in serum of chronically injected JNPL3 and Tg4510 transgenic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc158d79f650330acaec85ed60c831ae
https://pubmed.ncbi.nlm.nih.gov/26508157
https://pubmed.ncbi.nlm.nih.gov/26508157
Autor:
J. Lewis, Heidy Jimenez, Z. Liu, M. Lesser, B.S. Greenwald, Christopher M. Acker, Jeremy Koppel, Peter Davies, Cristina d'Abramo, M. Azose, Justin Buthorn
Publikováno v:
Behavioural brain research. 275
Psychotic Alzheimer's disease (AD+P) is a rapidly progressive variant of AD associated with an increased burden of frontal tau pathology that affects up to 50% of those with AD, and is observed more commonly in females. To date, there are no safe and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6483343b459d3836567ab7f30117d6b
https://pubmed.ncbi.nlm.nih.gov/25151619
https://pubmed.ncbi.nlm.nih.gov/25151619
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d0190e2d1da7ed0263df7316ddd9114
https://doi.org/10.1016/j.jalz.2013.05.1416
https://doi.org/10.1016/j.jalz.2013.05.1416