Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christopher M. Yea"'
Autor:
Danny M. Cohn, Emel Aygören‐Pürsün, Jonathan A. Bernstein, Henriette Farkas, William R. Lumry, Marcus Maurer, Andrea Zanichelli, Matthew Iverson, James Hao, Michael D. Smith, Christopher M. Yea, Paul K. Audhya, Marc A. Riedl
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 9, Pp n/a-n/a (2023)
Abstract Background Hereditary angioedema (HAE) with C1‐inhibitor deficiency (HAE‐C1‐INH) is characterized by recurrent, debilitating episodes of swelling. Sebetralstat, an investigational oral plasma kallikrein inhibitor, demonstrated promisin
Externí odkaz:
https://doaj.org/article/fa5357d5066e444bb5ad301768e9507f
Autor:
Andreas Maetzel, Michael D. Smith, Edward J. Duckworth, Sally L. Hampton, Gian Marco De Donatis, Nivetha Murugesan, Louise J. Rushbrooke, Lily Li, Danielle Francombe, Edward P. Feener, Christopher M. Yea
Publikováno v:
Journal of Allergy and Clinical Immunology. 149:2034-2042
Attacks of hereditary angioedema are attributed to excessive plasma kallikrein (PKa) activity, which cleaves high-molecular-weight kininogen to generate the proinflammatory hormone bradykinin.We evaluated the safety, tolerability, pharmacokinetics (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5d8250a19c23c9a10512bab9913d2f
https://doi.org/10.1016/j.jaci.2021.10.038
https://doi.org/10.1016/j.jaci.2021.10.038
Autor:
Edward J. Duckworth, Nivetha Murugesan, Lily Li, Louise J. Rushbrooke, Daniel K. Lee, Gian Marco De Donatis, Andreas Maetzel, Christopher M. Yea, Sally L. Hampton, Edward P. Feener
Publikováno v:
Clinical & Experimental Allergy. 52:1059-1070
Hereditary angioedema (HAE) is a rare genetic disease that leads to recurrent episodes of swelling and pain caused by uncontrolled plasma kallikrein (PKa) activity. Current guidelines recommend ready availability of on-demand HAE treatments that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fffe1d47acef7a53a0c4c6b2ef74f0
https://doi.org/10.1111/cea.14122
https://doi.org/10.1111/cea.14122
Autor:
Emel Aygören-Pürsün, Andrea Zanichelli, Danny M Cohn, Mauro Cancian, Roman Hakl, Tamar Kinaciyan, Markus Magerl, Inmaculada Martinez-Saguer, Marcin Stobiecki, Henriette Farkas, Sorena Kiani-Alikhan, Vesna Grivcheva-Panovska, Jonathan A Bernstein, H Henry Li, Hilary J Longhurst, Paul K Audhya, Michael D Smith, Christopher M Yea, Andreas Maetzel, Daniel K Lee, Edward P Feener, Richard Gower, William R Lumry, Aleena Banerji, Marc A Riedl, Marcus Maurer
Publikováno v:
The Lancet, 401(10375), 458-469. Elsevier Limited
Background: Guidelines recommend effective on-demand therapy for all individuals with hereditary angioedema. We aimed to assess the novel oral plasma kallikrein inhibitor, sebetralstat, which is in development, for on-demand treatment of hereditary a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd222b086018bb478d12029297cd21f
https://ruj.uj.edu.pl/xmlui/handle/item/309592
https://ruj.uj.edu.pl/xmlui/handle/item/309592
Autor:
Lily Li, Edward Duckworth, Michael D. Smith, Andreas Maetzel, Louise J. Rushbrooke, Sally L. Hampton, Gian Marco De Donatis, Nivetha Murugesan, Edward P. Feener, Christopher M. Yea, Rachel M. Morten
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:AB39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a3eb5a276cf13efee6943be9f6c0e3
https://doi.org/10.1016/j.jaci.2018.12.118
https://doi.org/10.1016/j.jaci.2018.12.118
Autor:
Christopher M. Yea, Christine E. Allan, Doreen M. Ashworth, James Barnett, Andy J. Baxter, Janice D. Broadbridge, Richard J. Franklin, Sally L. Hampton, Peter Hudson, John A. Horton, Paul D. Jenkins, Andy M. Penson, Gary R. W. Pitt, Pierre Rivière, Peter A. Robson, David P. Rooker, Graeme Semple, Andy Sheppard, Robert M. Haigh, Michael B. Roe
Publikováno v:
Journal of Medicinal Chemistry; Dec2008, Vol. 51 Issue 24, p8124-8134, 11p
Publikováno v:
Biochemical Society Transactions. 16:888-889
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e68d4d7dea7fd1c6feb83a5a8d0a2f
https://doi.org/10.1042/bst0160888
https://doi.org/10.1042/bst0160888