Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Christopher M Rath"'
Autor:
Daryl L Richie, Kenneth T Takeoka, Jade Bojkovic, Louis E Metzger, Christopher M Rath, William S Sawyer, Jun-Rong Wei, Charles R Dean
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160918 (2016)
The lipid A moiety of lipopolysaccharide (LPS) is the main constituent of the outer leaflet of the Gram-negative bacterial outer membrane (OM) and is essential in many Gram-negative pathogens. An exception is Acinetobacter baumannii ATCC 19606, where
Externí odkaz:
https://doaj.org/article/ddda739d74a845db853b3b3ed0f64e8c
Imaging mass spectrometry enables spatial metabolomics, yet metabolites can be assigned only to a fraction of the data generated. METASPACE-ML is a machine learning-based approach addressing this challenge. Integrating new scores and computationally-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8716580f1397ed94001f1929729bc584
https://doi.org/10.1101/2023.05.29.542736
https://doi.org/10.1101/2023.05.29.542736
Autor:
Christopher M. Rath, David A. Six, Inga Nilsson, William S. Sawyer, Guillaume Lapointe, Sheng Y. Lee
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 6, Pp 870-883 (2020)
Journal of Lipid Research, Vol 61, Iss 6, Pp 870-883 (2020)
Gram-negative bacteria possess an asymmetric outer membrane (OM) composed primarily of lipopolysaccharides (LPSs) on the outer leaflet and phospholipids (PLs) on the inner leaflet. The loss of this asymmetry due to mutations in the LPS biosynthesis o
Autor:
Ramadevi Prathapam, Alexandra Frommlet, Jacob Shaul, Dita M. Rasper, Xiaoyu Shen, Alexey Ruzin, Sharadha Subramanian, Feng Wang, Micah Steffek, Bret Benton, Jason Vo, Steven Shia, Wooseok Han, Andreas O. Frank, Charles Wartchow, Patrick Lee, Xiaolei Ma, Fergal Casey, Hanne Merritt, Carl J. Balibar, Alun Bermingham, Elizabeth Ornelas, Tsuyoshi Uehara, Andreas Lingel, Chi-Min Ho, Barbara Chie-Leon, William S. Sawyer, Min-Kyu Cho, Sylvia Ma, Katherine R Prosen, Min Li, Christopher M. Rath, Gianfranco De Pascale
Publikováno v:
Journal of the American Chemical Society. 142:4445-4455
The lipopolysaccharide biosynthesis pathway is considered an attractive drug target against the rising threat of multi-drug-resistant Gram-negative bacteria. Here, we report two novel small-molecule inhibitors (compounds 1 and 2) of the acyltransfera
Publikováno v:
ACS Chemical Biology. 14:725-734
Compartmentalization is a crucial facet of many biological systems, and key aspects of cellular processes rely on spatial segregation within the cell. While many drug targets reside in specific intracellular compartments, the tools available for asse
Autor:
Colin K. Skepper, Robert J. Moreau, Brent A. Appleton, Bret M. Benton, Joseph E. Drumm, Brian Y. Feng, Mei Geng, Cheng Hu, Cindy Li, Andreas Lingel, Yipin Lu, Mulugeta Mamo, Wosenu Mergo, Mina Mostafavi, Christopher M. Rath, Micah Steffek, Kenneth T. Takeoka, Kyoko Uehara, Lisha Wang, Jun-Rong Wei, Lili Xie, Wenjian Xu, Qiong Zhang, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 61:3325-3349
In the preceding manuscript [ Moreau et al. 2018 , 10.1021/acs.jmedchem.7b01691 ] we described a successful fragment-based lead discovery (FBLD) strategy for discovery of bacterial phosphopantetheine adenylyltransferase inhibitors (PPAT, CoaD). Follo
Autor:
Brian Y. Feng, Tsuyoshi Uehara, Ramadevi Prathapam, Mina Mostafavi, Pramila Tamrakar, Lisha Wang, Christopher M. Rath, William S. Sawyer, Louis E. Metzger
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 2, p e0211803 (2019)
PLoS ONE, Vol 14, Iss 2, p e0211803 (2019)
Lipopolysacharride (LPS) forms the outer leaflet of the outer membrane in Gram-negative bacteria and contributes to the permeability barrier and immune response. In this study, we established a method for monitoring the LPS biosynthetic intermediates
Autor:
Mina, Mostafavi, Lisha, Wang, Lili, Xie, Kenneth T, Takeoka, Daryl L, Richie, Fergal, Casey, Alexey, Ruzin, William S, Sawyer, Christopher M, Rath, Jun-Rong, Wei, Charles R, Dean
Publikováno v:
mSphere
Emergence of antibiotic resistance has prompted efforts to identify and optimize novel inhibitors of antibacterial targets such as LpxC. This enzyme catalyzes the first committed step of lipid A synthesis, which is necessary to generate lipopolysacch
Autor:
Alexey Ruzin, Fergal Casey, Lisha Wang, Charles R. Dean, William S. Sawyer, Kenneth T. Takeoka, Mina Mostafavi, Christopher M. Rath, Daryl L. Richie, Jun-Rong Wei, Lili Xie
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest for Gram-
Autor:
David A. Six, Daryl L. Richie, Jade Bojkovic, Charles R. Dean, Qijun Hu, Christopher M. Rath, William S. Sawyer
Publikováno v:
Journal of Bacteriology. 198:731-741
Lipid A on the Gram-negative outer membrane (OM) is synthesized in the cytoplasm by the Lpx pathway and translocated to the OM by the Lpt pathway. Some Acinetobacter baumannii strains can tolerate the complete loss of lipopolysaccharide (LPS) resulti