Výsledky vyhledávání - "Christopher M Mulligan"

Akademický článek

Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats.

Autor: Kimberly M Jeckel, D N Rao Veeramachaneni, Adam J Chicco, Phillip L Chapman, Christopher M Mulligan, Jennifer R Hegarty, Michael J Pagliassotti, Lindsay A Ferguson, Gerrit J Bouma, Melinda A Frye

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51994 (2012)

Obesity increases risk for cardiomyopathy in the absence of hypertension, diabetes or ischemia. The fatty acid milieu, modulated by diet, may modify myocardial structure and function, lending partial explanation for the array of cardiomyopathic pheno

Externí odkaz: https://doaj.org/article/e35eb439d9bb410eb1ececc857f37bee

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Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates

Autor: Carrie E. McCurdy, Kenneth N. Maclean, Paul Kievit, Bryan C. Bergman, Rachel C. Janssen, Peter R. Baker, Christopher M. Mulligan, Tyler Dean, Diana L. Takahashi, Travis Nemkov, Kjersti Aagaard, Hua Jiang, Stephanie R. Wesolowski, Angelo D'Alessandro, Jacob E. Friedman

Publikováno v: Molecular Metabolism, Vol 18, Iss, Pp 25-41 (2018)
Molecular Metabolism

Objective Non-alcoholic fatty liver disease (NAFLD) risk begins in utero in offspring of obese mothers. A critical unmet need in this field is to understand the pathways and biomarkers underlying fetal hepatic lipotoxicity and whether maternal dietar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06dccd8288a52f01636dbe7fd72ba0f
https://doi.org/10.1016/j.molmet.2018.09.008

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Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria

Autor: Lance C. Li Puma, Adam J. Chicco, Jessica E. Prenni, Christopher M. Mulligan, Adam L. Heuberger, Kathryn C. Chatfield, Genevieve C. Sparagna, Catherine H. Le, Lindsay G. Benage, Steven M. Claypool, Kalyn S. Specht

Publikováno v: J Biol Chem

Barth syndrome is a mitochondrial myopathy resulting from mutations in the tafazzin (TAZ) gene encoding a phospholipid transacylase required for cardiolipin remodeling. Cardiolipin is a phospholipid of the inner mitochondrial membrane essential for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7159138b473d83f865faa35050303c18
https://pubmed.ncbi.nlm.nih.gov/32665401

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Abstract 228: FADS2 Regulates Cardiometabolic Risk Phenotypes in Mice

Autor: Adam J Chicco, Christopher M Mulligan, Catherine H Le, Melissa A Routh, Dina Nemr, Lance C Li Puma, Peter E Linde, Gerrit J Bouma, Daniel P Regan, Manabu T Nakamura, Karen S Moulton

Publikováno v: Circulation Research. 121

Single nucleotide polymorphisms of the FADS2 gene associate with cardiometabolic risk in humans. Additionally, serum fatty acid profiles reflecting hepatic hyperactivity of the FADS2 gene product, delta-6 desaturase (D6D), correspond to cardiometabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4602b7c4cba9fa7b48764a6eed3339b
https://doi.org/10.1161/res.121.suppl_1.228

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Maternal modifiers of the infant gut microbiota: metabolic consequences

Autor: Jacob E. Friedman, Christopher M. Mulligan

Publikováno v: The Journal of endocrinology. 235(1)

Transmission of metabolic diseases from mother to child is multifactorial and includes genetic, epigenetic and environmental influences. Evidence in rodents, humans and non-human primates support the scientific premise that exposure to maternal obesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39313bc65693258c56038f8a62c8b91
https://pubmed.ncbi.nlm.nih.gov/28751453

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Delta-6-desaturase Links Polyunsaturated Fatty Acid Metabolism With Phospholipid Remodeling and Disease Progression in Heart Failure

Autor: Catherine H. Le, Robert C. Murphy, Christopher M. Mulligan, Gerrit J. Bouma, Melissa A. Routh, Michael R. Bristow, Russell L. Moore, Genevieve C. Sparagna, Kimberly M. Jeckel, Sylvia A. McCune, Simona Zarini, Adam J. Chicco, Melinda A. Frye, Joshua M. Lynch

Publikováno v: Circulation: Heart Failure. 7:172-183

Background— Remodeling of myocardial phospholipids has been reported in various forms of heart failure for decades, but the mechanism and pathophysiological relevance of this phenomenon have remained unclear. We examined the hypothesis that δ-6 de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0846efe3f99ef5b51b974a97576e724
https://doi.org/10.1161/circheartfailure.113.000744

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