Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Christopher M Johnson"'
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010065 (2022)
Most bacterial genomes contain horizontally acquired and transmissible mobile genetic elements, including temperate bacteriophages and integrative and conjugative elements. Little is known about how these elements interact and co-evolved as parts of
Externí odkaz:
https://doaj.org/article/43180c1b48b44f7a9779633538b91282
Autor:
Yohei Ohashi, Shirley Tremel, Glenn Robert Masson, Lauren McGinney, Jerome Boulanger, Ksenia Rostislavleva, Christopher M Johnson, Izabella Niewczas, Jonathan Clark, Roger L Williams
Publikováno v:
eLife, Vol 9 (2020)
The lipid kinase VPS34 orchestrates diverse processes, including autophagy, endocytic sorting, phagocytosis, anabolic responses and cell division. VPS34 forms various complexes that help adapt it to specific pathways, with complexes I and II being th
Externí odkaz:
https://doaj.org/article/7d8937877eeb407298a9c962587ff946
Autor:
Mark A McClintock, Carly I Dix, Christopher M Johnson, Stephen H McLaughlin, Rory J Maizels, Ha Thi Hoang, Simon L Bullock
Publikováno v:
eLife, Vol 7 (2018)
Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood. We have reconstituted m
Externí odkaz:
https://doaj.org/article/f9a825dc82dd4a8997f0d28da58a24f0
Autor:
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James
Publikováno v:
eLife, Vol 7 (2018)
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknow
Externí odkaz:
https://doaj.org/article/5202b947b0ec499ebb78db70bf28d54e
Autor:
Xin Jin, Shanshan Li, Brian Bondy, Weiwei Zhong, Max F Oginsky, Yang Wu, Christopher M Johnson, Shuang Zhang, Ningren Cui, Chun Jiang
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146470 (2016)
The locus coeruleus (LC)-norepinephrine (NE) system in the brainstem plays a critical role in a variety of behaviors is an important target of pharmacological intervention to several neurological disorders. Although GABA is the major inhibitory neuro
Externí odkaz:
https://doaj.org/article/743874c2e9de411e962c3991bc1e0c5a
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005556 (2015)
We identified a functional single strand origin of replication (sso) in the integrative and conjugative element ICEBs1 of Bacillus subtilis. Integrative and conjugative elements (ICEs, also known as conjugative transposons) are DNA elements typically
Externí odkaz:
https://doaj.org/article/92116b1b35604da4bf7a9cc4257ecb91
Autor:
Marc Fiedler, Michael Graeb, Juliusz Mieszczanek, Trevor J Rutherford, Christopher M Johnson, Mariann Bienz
Publikováno v:
eLife, Vol 4 (2015)
TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer. β-cat
Externí odkaz:
https://doaj.org/article/94d870777074496daa3127aa48404953
Publikováno v:
eLife, Vol 3 (2014)
Externí odkaz:
https://doaj.org/article/e2db0a369f124ef8be4c05b70b8a5475
Publikováno v:
eLife, Vol 3 (2014)
Filaments of all actin-like proteins known to date are assembled from pairs of protofilaments that are arranged in a parallel fashion, generating polarity. In this study, we show that the prokaryotic actin homologue MreB forms pairs of protofilaments
Externí odkaz:
https://doaj.org/article/ad21a6020ae34f8ca88ac5dfc13e46dc
Autor:
Mark van Breugel, Rainer Wilcken, Stephen H McLaughlin, Trevor J Rutherford, Christopher M Johnson
Publikováno v:
eLife, Vol 3 (2014)
Centrioles are cylindrical cell organelles with a ninefold symmetric peripheral microtubule array that is essential to template cilia and flagella. They are built around a central cartwheel assembly that is organized through homo-oligomerization of t
Externí odkaz:
https://doaj.org/article/cef7a151909f416f85fda12a6d616c05