Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Christopher M Heaphy"'
Autor:
Christopher M Heaphy, Corinne E Joshu, John R Barber, Christine Davis, Jiayun Lu, Reza Zarinshenas, Edward Giovannucci, Lorelei A Mucci, Meir J Stampfer, Misop Han, Angelo M De Marzo, Tamara L Lotan, Elizabeth A Platz, Alan K Meeker
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 5, Pp 481-491 (2022)
Abstract Current biomarkers are inadequate prognostic predictors in localized prostate cancer making treatment decision‐making challenging. Previously, we observed that the combination of more variable telomere length among prostate cancer cells an
Externí odkaz:
https://doaj.org/article/d83e9cf0b5244fd6a2439370f8fc6cb4
Autor:
Jacqueline A Brosnan-Cashman, Ming Yuan, Mindy K Graham, Anthony J Rizzo, Kaylar M Myers, Christine Davis, Rebecca Zhang, David M Esopi, Eric H Raabe, Charles G Eberhart, Christopher M Heaphy, Alan K Meeker
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204159 (2018)
Cancers must maintain their telomeres at lengths sufficient for cell survival. In several cancer subtypes, a recombination-like mechanism termed alternative lengthening of telomeres (ALT), is frequently used for telomere length maintenance. Cancers u
Externí odkaz:
https://doaj.org/article/b76ec1db4ff34f8f9b0deeabfb821ff4
Autor:
Christopher M. Heaphy, Aatur D. Singhi
Publikováno v:
Human Pathology. 129:11-20
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms with increasing incidence and an ill-defined pathobiology. Although many PanNETs are indolent and remain stable for years, a subset may behave aggressively and metastas
Autor:
Onur Ertunc, Erica Smearman, Qizhi Zheng, Jessica L. Hicks, Jacqueline A. Brosnan-Cashman, Tracy Jones, Carolina Gomes-Alexandre, Levent Trabzonlu, Alan K. Meeker, Angelo M. De Marzo, Christopher M. Heaphy
Telomeres are terminal chromosomal elements that are essential for the maintenance of genomic integrity. The measurement of telomere content provides useful diagnostic and prognostic information, and fluorescent methods have been developed for this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ef1a1ba0a18aa40f37adf6313ce02f2
https://doi.org/10.1101/2023.04.04.535575
https://doi.org/10.1101/2023.04.04.535575
Autor:
Elizabeth A. Platz, Alan K. Meeker, Angelo M. De Marzo, Jessica L. Hicks, Thomas K. Lee, GhilSuk Yoon, Meir J. Stampfer, Edward L. Giovannucci, Lorelei A. Mucci, Erin L. Van Blarigan, Stacey A. Kenfield, Christopher M. Heaphy, Sarah B. Peskoe, Corinne E. Joshu
Obesity and inactivity have been associated with advanced-stage prostate cancer, and poor prostate cancer outcomes, though the underlying mechanism(s) is unknown. To determine whether telomere shortening, which has been associated with lethal prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd824aaff37b13b2db125bd02e41c091
https://doi.org/10.1158/1940-6207.c.6545247.v1
https://doi.org/10.1158/1940-6207.c.6545247.v1
Autor:
Elizabeth A. Platz, Alan K. Meeker, Angelo M. De Marzo, Jessica L. Hicks, Thomas K. Lee, GhilSuk Yoon, Meir J. Stampfer, Edward L. Giovannucci, Lorelei A. Mucci, Erin L. Van Blarigan, Stacey A. Kenfield, Christopher M. Heaphy, Sarah B. Peskoe, Corinne E. Joshu
Supplemental Table 1 and 2. Association of pre-diagnostic BMI, waist circumference, weight change from age 21, total physical activity and vigorous physical activity with telomere length (Supplemental Table 1) and telomere variability (Supplemental T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ff31be3aaebb5461ff4357b9e816be
https://doi.org/10.1158/1940-6207.22526913.v1
https://doi.org/10.1158/1940-6207.22526913.v1
Autor:
Elizabeth A. Platz, Alan K. Meeker, Angelo M. De Marzo, Karen S. Sfanos, Tamara L. Lotan, Misop Han, Christine Davis, Reza Zarinshenas, Jiayun Lu, John R. Barber, Christopher M. Heaphy, Corinne E. Joshu
Odds ratios (OR) and 95% confidence intervals (CI) for the association between body mass index (BMI) category and telomere variability* in prostate cancer cells overall and stratified by prostate cancer aggressiveness at surgery among men surgically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425bfed432ab29986cfe26ffe2bf5b85
https://doi.org/10.1158/1940-6207.22533367
https://doi.org/10.1158/1940-6207.22533367
Autor:
Christopher M. Heaphy, Alan K. Meeker, Angelo M. De Marzo, Michael C. Haffner, Michael Considine, Leslie Cope, Qizhi Zheng, Christine Davis, Michael Rubenstein, Lionel Chia, Javier A. Baena Del Valle, Anthony Rizzo, Jacqueline A. Brosnan-Cashman, Joseph Da, Jiyoung Kim, Mindy K. Graham
Table S1. Sequences of oligonucleotides for CRISPR, telomere assays, and RT-qPCR. Table S2. Mean telomere lengths assessed from TRF southern blots of LAPC-4 EV and ATRXKO clones, and CWR22Rv1 EV and ATRXKO clones. Table S3. Microarray results of top
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52650f0d7f552024397c8accb09251af
https://doi.org/10.1158/1541-7786.22512513
https://doi.org/10.1158/1541-7786.22512513
Autor:
Elizabeth A. Platz, Alan K. Meeker, Angelo M. De Marzo, Karen S. Sfanos, Tamara L. Lotan, Misop Han, Christine Davis, Reza Zarinshenas, Jiayun Lu, John R. Barber, Christopher M. Heaphy, Corinne E. Joshu
In our prior studies, obesity was associated with shorter telomeres in prostate cancer-associated stromal (CAS) cells, and shorter CAS telomeres were associated with an increased risk of prostate cancer death. To determine whether the association bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69736bd9493bd91ca9f68ce6e645882
https://doi.org/10.1158/1940-6207.c.6547042.v1
https://doi.org/10.1158/1940-6207.c.6547042.v1
Autor:
Christopher M. Heaphy, Alan K. Meeker, Angelo M. De Marzo, Michael C. Haffner, Michael Considine, Leslie Cope, Qizhi Zheng, Christine Davis, Michael Rubenstein, Lionel Chia, Javier A. Baena Del Valle, Anthony Rizzo, Jacqueline A. Brosnan-Cashman, Joseph Da, Jiyoung Kim, Mindy K. Graham
A key hallmark of cancer, unlimited replication, requires cancer cells to evade both replicative senescence and potentially lethal chromosomal instability induced by telomere dysfunction. The majority of cancers overcome these critical barriers by up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a4535a129772c3bc084407cc691c613
https://doi.org/10.1158/1541-7786.c.6540264.v1
https://doi.org/10.1158/1541-7786.c.6540264.v1