NOX2 in Alzheimer's and Parkinson's disease

Autor: Christopher M. Dustin, Sruti S. Shiva, Alberto Vazquez, Anum Saeed, Tharick Pascoal, Eugenia Cifuentes-Pagano, Patrick J. Pagano

Publikováno v: Redox Biology, Vol 78, Iss , Pp 103433- (2024)

Alzheimer's Disease (AD), and related dementias, represent a growing concern for the worldwide population given the increased numbers of people of advanced age. Marked by significant degradation of neurological tissues and critical processes, in addi

Externí odkaz: https://doaj.org/article/22148d7ff69948fbba041522342a4993

Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease

Autor: Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F.M. Wouters, Niki L. Reynaert, Albert van der Vliet

Publikováno v: JCI Insight, Vol 6, Iss 2 (2021)

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by small airway remodeling and alveolar emphysema due to environmental stresses such as cigarette smoking (CS). Oxidative stress is commonly implicated in COP

Externí odkaz: https://doaj.org/article/ca13401081aa4805b072e1b3e5465641

Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

Autor: David E. Heppner, Milena Hristova, Tomoaki Ida, Ana Mijuskovic, Christopher M. Dustin, Virág Bogdándi, Jon M. Fukuto, Tobias P. Dick, Péter Nagy, Jianing Li, Takaaki Akaike, Albert van der Vliet

Publikováno v: Redox Biology, Vol 14, Iss , Pp 379-385 (2018)

The reversible oxidation of protein cysteine residues (Cys-SH) is a key reaction in cellular redox signaling involving initial formation of sulfenic acids (Cys-SOH), which are commonly detected using selective dimedone-based probes. Here, we report t

Externí odkaz: https://doaj.org/article/898f22d00edd48fb8263a51951fa70c8

Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema

Autor: Christopher M. Dustin, Nirav Daphtary, Caspar Schiffers, Lennart K. A. Lundblad, Niki L. Reynaert, Emiel F.M. Wouters, Albert van der Vliet, Minara Aliyeva, David J. Seward, Milena Hristova, Yvonne M. W. Janssen-Heininger, Aida Habibovic

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(1), L144-L158. American Physiological Society
Am J Physiol Lung Cell Mol Physiol

Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial host defense to nonmicrobial triggers i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7b682d676a388c62b278898341509c
https://doi.org/10.1152/ajplung.00021.2021

The Transient Receptor Potential Channel Vanilloid 1 Is Critical in Innate Airway Epithelial Responses to Protease Allergens

Autor: Christopher M. Dustin, Caspar Schiffers, Aida Habibovic, Niki L. Reynaert, Milena Hristova, Karamatullah Danyal, Emiel F.M. Wouters, Albert van der Vliet

Publikováno v: American Journal of Respiratory Cell and Molecular Biology, 63(2), 198-208. American Thoracic Society
Am J Respir Cell Mol Biol

The airway epithelium plays a critical role in innate responses to airborne allergens by secreting IL-1 family cytokines such as IL-1 alpha and IL-33 as alarmins that subsequently orchestrate appropriate immune responses. Previous studies revealed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814fc8ca72168db75d483cf27c8b3abf
https://doi.org/10.1165/rcmb.2019-0170oc