Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christopher M Dustin"'
Autor:
Evan R. DeVallance, Christopher M. Dustin, Daniel Simoes de Jesus, Imad Al Ghouleh, John C. Sembrat, Eugenia Cifuentes-Pagano, Patrick J. Pagano
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 71 (2022)
Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with few treatment options. The underlying mechanisms of PAH appear to involve substantial cellular proliferation and vascular remodeling, causing right ventricular
Externí odkaz:
https://doaj.org/article/635c07f3c54844fa969104d819b7bff9
Autor:
David E. Heppner, Christopher M. Dustin, Chenyi Liao, Milena Hristova, Carmen Veith, Andrew C. Little, Bethany A. Ahlers, Sheryl L. White, Bin Deng, Ying-Wai Lam, Jianing Li, Albert van der Vliet
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The activity of several protein kinases is increased upon cellular production of reactive oxygen species, which can cause cysteine oxidation. Here the authors show that sulfenylation of specific cysteine residues within Src induce local structural ch
Externí odkaz:
https://doaj.org/article/224ec0c26833440495e8da4a22aecfde
Autor:
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F.M. Wouters, Niki L. Reynaert, Albert van der Vliet
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by small airway remodeling and alveolar emphysema due to environmental stresses such as cigarette smoking (CS). Oxidative stress is commonly implicated in COP
Externí odkaz:
https://doaj.org/article/ca13401081aa4805b072e1b3e5465641
Autor:
David E. Heppner, Milena Hristova, Tomoaki Ida, Ana Mijuskovic, Christopher M. Dustin, Virág Bogdándi, Jon M. Fukuto, Tobias P. Dick, Péter Nagy, Jianing Li, Takaaki Akaike, Albert van der Vliet
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 379-385 (2018)
The reversible oxidation of protein cysteine residues (Cys-SH) is a key reaction in cellular redox signaling involving initial formation of sulfenic acids (Cys-SOH), which are commonly detected using selective dimedone-based probes. Here, we report t
Externí odkaz:
https://doaj.org/article/898f22d00edd48fb8263a51951fa70c8
Autor:
Carolyn R. Morris, Aida Habibovic, Christopher M. Dustin, Caspar Schiffers, Miao-Chong Lin, Jennifer L. Ather, Yvonne M.W. Janssen-Heininger, Matthew E. Poynter, Olaf Utermohlen, Martin Krönke, Albert van der Vliet
Publikováno v:
Mucosal Immunology. 15:977-989
Autor:
Christopher M. Dustin, Nirav Daphtary, Caspar Schiffers, Lennart K. A. Lundblad, Niki L. Reynaert, Emiel F.M. Wouters, Albert van der Vliet, Minara Aliyeva, David J. Seward, Milena Hristova, Yvonne M. W. Janssen-Heininger, Aida Habibovic
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(1), L144-L158. American Physiological Society
Am J Physiol Lung Cell Mol Physiol
Am J Physiol Lung Cell Mol Physiol
Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial host defense to nonmicrobial triggers i
Autor:
Carolyn R. Morris, Miao-Chong Joy Lin, Minara Aliyeva, Robert A. Bauer, David E. Heppner, Aida Habibovic, Albert van der Vliet, Nirav Daphtary, Milena Hristova, Christopher M. Dustin, Caspar Schiffers
Publikováno v:
Journal of Immunology, 206(12), 2989-2999. American Association of Immunologists
J Immunol
J Immunol
The respiratory epithelium forms the first line of defense against inhaled pathogens and acts as an important source of innate cytokine responses to environmental insults. One critical mediator of these responses is the IL-1 family cytokine IL-33, wh
Publikováno v:
J Biochem
Protein kinases are essential mediators of cellular signal transduction and are often dysregulated in disease. Among these, protein tyrosine kinases (PTKs) have received specific interest due to their common roles in various diseases including cancer
Autor:
Carolyn R, Morris, Aida, Habibovic, Christopher M, Dustin, Caspar, Schiffers, Miao-Chong, Lin, Jennifer L, Ather, Yvonne M W, Janssen-Heininger, Matthew E, Poynter, Olaf, Utermohlen, Martin, Krönke, Albert, van der Vliet
Publikováno v:
Mucosal immunology. 15(5)
The NADPH oxidase DUOX1 contributes to epithelial production of alarmins, including interleukin (IL)-33, in response to injurious triggers such as airborne protease allergens, and mediates development of mucus metaplasia and airway remodeling in chro
Autor:
Christopher M. Dustin, Nicolas Kahn, Marc A. Schneider, Agnes W. Boots, Veith Carmen, Frederik-Jan van Schooten, Albert van der Vliet, Michael Kreuter, Milena Hristova
Publikováno v:
Mechanisms of lung injury and repair.