Zobrazeno 1 - 10
of 1 007
pro vyhledávání: '"Christopher M Dobson"'
Autor:
Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, Maria Sladowska, Michal Turek, Barbara Uszczynska-Ratajczak, Rishika Kundra, Tomasz Goral, Michele Perni, Christopher M Dobson, Michele Vendruscolo, Agnieszka Chacinska
Publikováno v:
eLife, Vol 10 (2021)
Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to understand whether failures in the mitochondrial uptake of these nuc
Externí odkaz:
https://doaj.org/article/bde42a68f5f14029a3273e815c975f47
Autor:
Emil Dandanell Agerschou, Patrick Flagmeier, Theodora Saridaki, Céline Galvagnion, Daniel Komnig, Laetitia Heid, Vibha Prasad, Hamed Shaykhalishahi, Dieter Willbold, Christopher M Dobson, Aaron Voigt, Bjoern Falkenburger, Wolfgang Hoyer, Alexander K Buell
Publikováno v:
eLife, Vol 8 (2019)
Removing or preventing the formation of [Formula: see text]-synuclein aggregates is a plausible strategy against Parkinson’s disease. To this end, we have engineered the [Formula: see text]-wrapin AS69 to bind monomeric [Formula: see text]-synuclei
Externí odkaz:
https://doaj.org/article/1487d7db37e74f7e9d5d15b7c82df34c
Autor:
Tessa Sinnige, Prashanth Ciryam, Samuel Casford, Christopher M Dobson, Mario de Bono, Michele Vendruscolo
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217746 (2019)
Although the aggregation of the amyloid-β peptide (Aβ) into amyloid fibrils is a well-established hallmark of Alzheimer's disease, the complex mechanisms linking this process to neurodegeneration are still incompletely understood. The nematode worm
Externí odkaz:
https://doaj.org/article/e1dcb596c3114b9f92b8a5ac45aaf50c
Autor:
David C Butler, Shubhada N Joshi, Erwin De Genst, Ankit S Baghel, Christopher M Dobson, Anne Messer
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165964 (2016)
Misfolding, abnormal accumulation, and secretion of α-Synuclein (α-Syn) are closely associated with synucleinopathies, including Parkinson's disease (PD). VH14 is a human single domain intrabody selected against the non-amyloid component (NAC) hydr
Externí odkaz:
https://doaj.org/article/fda9170016e14126bcbaf644edb3fdcf
Autor:
Mookyung Cheon, Iksoo Chang, Sandipan Mohanty, Leila M Luheshi, Christopher M Dobson, Michele Vendruscolo, Giorgio Favrin
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 9, Pp 1727-1738 (2007)
Increasing evidence indicates that oligomeric protein assemblies may represent the molecular species responsible for cytotoxicity in a range of neurological disorders including Alzheimer and Parkinson diseases. We use all-atom computer simulations to
Externí odkaz:
https://doaj.org/article/26e62cab93244385a7f6815d4adeb4f9
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130036 (2015)
Alpha-2-macroglobulin is an abundant secreted protein that is of particular interest because of its diverse ligand binding profile and multifunctional nature, which includes roles as a protease inhibitor and as a molecular chaperone. The activities o
Externí odkaz:
https://doaj.org/article/589d9da82f1d412998bcdddb1a1bcb58
Autor:
Jenny Dworzak, Benoît Renvoisé, Johnny Habchi, Emma V Yates, Christophe Combadière, Tuomas P Knowles, Christopher M Dobson, Craig Blackstone, Ole Paulsen, Philip M Murphy
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127730 (2015)
Cx3cr1, the receptor for the chemokine Cx3cl1 (fractalkine), has been implicated in the progression and severity of Alzheimer's disease-like pathology in mice, but the underlying mechanisms remain unclear. A complicating factor is that Cx3cr1 has bee
Externí odkaz:
https://doaj.org/article/ffe644bd90094fc3a750f74851bfe2dc
Autor:
Alfonso De Simone, Francesco A Aprile, Anne Dhulesia, Christopher M Dobson, Michele Vendruscolo
Publikováno v:
eLife, Vol 4 (2015)
Enzymes can increase the rate of biomolecular reactions by several orders of magnitude. Although the steps of substrate capture and product release are essential in the enzymatic process, complete atomic-level descriptions of these steps are difficul
Externí odkaz:
https://doaj.org/article/cfa25ee8d4834facbee8cc774bfd8fac
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85185 (2014)
The ability of many proteins to convert from their functional soluble state to amyloid fibrils can be attributed to inter-molecular beta strand formation. Such amyloid formation is associated with neurodegenerative disorders like Alzheimer's and Park
Externí odkaz:
https://doaj.org/article/627688284ed74dc2b11f68dd06e81bbf
Autor:
Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Susan L Roy, Mitali A Tambe, Jean-Christophe Rochet, Celine Galvagnion, Gaia Skibinski, Steven Finkbeiner, Michael Bova, Karin Regnstrom, San-San Chiou, Jennifer Johnston, Kari Callaway, John P Anderson, Michael F Jobling, Alexander K Buell, Ted A Yednock, Tuomas P J Knowles, Michele Vendruscolo, John Christodoulou, Christopher M Dobson, Dale Schenk, Lisa McConlogue
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87133 (2014)
The misfolding of intrinsically disordered proteins such as α-synuclein, tau and the Aβ peptide has been associated with many highly debilitating neurodegenerative syndromes including Parkinson's and Alzheimer's diseases. Therapeutic targeting of t
Externí odkaz:
https://doaj.org/article/8d157123a35749c6bb540eccd1da403e