Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christopher M DaCosta"'
Autor:
Christopher M. DaCosta, Robert Brommage, Isaac Van Sligtenhorst, Zhi-Ming Ding, Gwenn M. Hansen, Kenneth A. Platt, Jean-Pierre Revelli, Deon Doree, David R. Powell
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:2641-2652
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1241da8071ecf353792b00269b89ba
https://doi.org/10.2147/dmso.s259546
https://doi.org/10.2147/dmso.s259546
Autor:
David R Powell, Deon D Doree, Christopher M DaCosta, Kenneth A Platt, Robert Brommage, Lindsey Buhring, Jean-Pierre Revelli, Melanie K Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.
David R Powell,1 Deon D Doree,1 Christopher M DaCosta,1 Kenneth A Platt,2 Robert Brommage,1 Lindsey Buhring,1 Jean-Pierre Revelli,1 Melanie K Shadoan1 1Department of Pharmaceutical Biology, Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA; 2Depar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33643fb27a8877ae6bb4e8757ee67c5
https://www.dovepress.com/mice-lacking-gpr75-are-hypophagic-and-thin-peer-reviewed-fulltext-article-DMSO
https://www.dovepress.com/mice-lacking-gpr75-are-hypophagic-and-thin-peer-reviewed-fulltext-article-DMSO
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Robert, Brommage, Lindsey, Buhring, Jean-Pierre, Revelli, Melanie K, Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose Humans with haploinsufficiency of GPR75, an orphan GPCR, are thin. Gpr75 knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm these findings in Gpr75 KO mice and determine whether decreased energy intake an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::297a542c63b91289d72014b3b34f4748
https://pubmed.ncbi.nlm.nih.gov/35023939
https://pubmed.ncbi.nlm.nih.gov/35023939
Autor:
Christopher M. DaCosta, Melissa Hansard, R. Read, David R. Powell, Daniel L. Small, Zhi-Ming Ding, Peter Vogel, Gwenn M. Hansen, Robert Brommage, Gui-Lan Ye
Publikováno v:
Veterinary pathology. 57(5)
Mice with an inactivating mutation in the gene encoding asparagine synthetase domain containing 1 (ASNSD1) develop a progressive degenerative myopathy that results in severe sarcopenia and myosteatosis. ASNSD1 is conserved across many species, and wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2661510677a5706fabd524d9f85925c8
https://pubmed.ncbi.nlm.nih.gov/32638637
https://pubmed.ncbi.nlm.nih.gov/32638637
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Gwenn M, Hansen, Isaac, van Sligtenhorst, Zhi-Ming, Ding, Jean-Pierre, Revelli, Robert, Brommage
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11ad3ff60e157b814ea6ccc362bf14f8
https://pubmed.ncbi.nlm.nih.gov/32801815
https://pubmed.ncbi.nlm.nih.gov/32801815
Autor:
Alan Wilson, Angela L. Harris, Brian Zambrowicz, Wendy Xiong, Christopher M. DaCosta, David R. Powell, Bryce Alden Harrison, Nicole Cathleen Goodwin, Melinda Smith, Sabrina Jeter-Jones, Andrea Y. Thompson, Eric Strobel, Faika Mseeh, David B. Rawlins, Jennifer Greer, Deon Doree, Suma Gopinathan, Kenneth G. Carson, Zhi-Ming Ding
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(1)
LX2761 is a potent sodium/glucose cotransporter 1 inhibitor restricted to the intestinal lumen after oral administration. Studies presented here evaluated the effect of orally administered LX2761 on glycemic control in preclinical models. In healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38140540d80f7939267c966c2d73c1da
https://pubmed.ncbi.nlm.nih.gov/28442582
https://pubmed.ncbi.nlm.nih.gov/28442582
Autor:
Jan Domin, Nianhua Xu, Christopher M. DaCosta, David P. Harris, Karen Moberg, Marie Wims, Kanchan G. Jhaver, Juliane Humphries, Melanie K. Shadoan, Tamas Oravecz, Sanjeevi Balakrishnan, Peter Vogel, David R. Powell, Gwenn M. Hansen
Publikováno v:
Molecular and Cellular Biology. 31:63-80
An early lesion in many kidney diseases is damage to podocytes, which are critical components of the glomerular filtration barrier. A number of proteins are essential for podocyte filtration function, but the signaling events contributing to developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63c10c9da9beafc11877bc9f5638396
https://doi.org/10.1128/mcb.00468-10
https://doi.org/10.1128/mcb.00468-10
Autor:
Christopher M. DaCosta, J. Wingert, Peter Vogel, Lindsey Buhring, R. Read, Melanie K. Shadoan, Gwenn M. Hansen
Publikováno v:
Veterinary Pathology. 48:642-654
Congenital generalized lipodystrophy (CGL) comprises a heterogeneous group of rare diseases associated with partial or total loss of adipose tissue. Of these, autosomal recessive Berardinelli–Seip congenital lipodystrophy (BSCL) is characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ce603b46a4bdbfe2973f5b8f0a558e
https://doi.org/10.1177/0300985810383870
https://doi.org/10.1177/0300985810383870
Autor:
C. Jones, T. Issa, C. M. Gelfman, David R. Powell, Peter Vogel, Gwenn M. Hansen, Bobby Joe Payne, Meagan R. Pitcher, Christopher M. DaCosta, R. B. Vance, Zhi-Ming Ding, Melanie K. Shadoan, R. Read
Publikováno v:
Veterinary pathology. 52(3)
Mice deficient in TMEM218 ( Tmem218–/–) were generated as part of an effort to identify and validate pharmaceutically tractable targets for drug development through large-scale phenotypic screening of knockout mice. Routine diagnostics, expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c333e63f42b864251659ee2841edd0e
https://pubmed.ncbi.nlm.nih.gov/25161209
https://pubmed.ncbi.nlm.nih.gov/25161209
Autor:
David R. Powell, Christopher M. DaCosta, Jason Gay, Zhi-Ming Ding, Melinda Smith, Jennifer Greer, Deon Doree, Sabrina Jeter-Jones, Faika Mseeh, Lawrence A. Rodriguez, Angela Harris, Lindsey Buhring, Kenneth A. Platt, Peter Vogel, Robert Brommage, Melanie K. Shadoan, Arthur T. Sands, Brian Zambrowicz
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 304(2)
Sodium-glucose cotransporter 2 (SGLT2) is the major, and SGLT1 the minor, transporter responsible for renal glucose reabsorption. Increasing urinary glucose excretion (UGE) by selectively inhibiting SGLT2 improves glycemic control in diabetic patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9c2205731253f0e0d28fbca1eb23ca
https://pubmed.ncbi.nlm.nih.gov/23149623
https://pubmed.ncbi.nlm.nih.gov/23149623