Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Christopher M Counter"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0292189 (2024)
Mice engineered with a G12D versus Q61R mutation in Kras exhibited differences in tumorigenesis. Namely, the incidence or grade of oral or forestomach squamous epithelial lesions was more prevalent in the KrasG12D background while hematolymphopoietic
Externí odkaz:
https://doaj.org/article/6c125ce0938544da835593d2ab1a6bbe
Autor:
Özgün Le Roux, Nicole LK Pershing, Erin Kaltenbrun, Nicole J Newman, Jeffrey I Everitt, Elisa Baldelli, Mariaelena Pierobon, Emanuel F Petricoin, Christopher M Counter
Publikováno v:
eLife, Vol 11 (2022)
Despite multiple possible oncogenic mutations in the proto-oncogene KRAS, unique subsets of these mutations are detected in different cancer types. As KRAS mutations occur early, if not being the initiating event, these mutational biases are ostensib
Externí odkaz:
https://doaj.org/article/dd9835a4ba684963a09df745f1a58e3a
Autor:
Scott R Allen, Rebeccah K Stewart, Michael Rogers, Ivan Jimenez Ruiz, Erez Cohen, Alain Laederach, Christopher M Counter, Jessica K Sawyer, Donald T Fox
Publikováno v:
eLife, Vol 11 (2022)
Codon usage bias has long been appreciated to influence protein production. Yet, relatively few studies have analyzed the impacts of codon usage on tissue-specific mRNA and protein expression. Here, we use codon-modified reporters to perform an organ
Externí odkaz:
https://doaj.org/article/6c13272b3ef34ec284eeebefc16be53b
Autor:
Siqi Li, Christopher M Counter
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0267147 (2022)
The carcinogen urethane induces pulmonary tumors in mice initiated by an incredibly specific Q61L/R oncogenic mutation in the proto-oncogene Kras. Previous Whole-Exome Sequencing of urethane-induced tumors revealed a bias towards A➙T/G and G➙A su
Externí odkaz:
https://doaj.org/article/74f6216bd62f492596f3a323153f2041
Autor:
Siqi Li, Christopher M Counter
Publikováno v:
eLife, Vol 10 (2021)
RAS genes are commonly mutated in human cancer. Despite many possible mutations, individual cancer types often have a ‘tropism’ towards a specific subset of RAS mutations. As driver mutations, these patterns ostensibly originate from normal cells
Externí odkaz:
https://doaj.org/article/e41f907a9d5e4ecbb00d0c3b0e4b9fd0
Autor:
Jessica K Sawyer, Zahra Kabiri, Ruth A Montague, Scott R Allen, Rebeccah Stewart, Sarah V Paramore, Erez Cohen, Hamed Zaribafzadeh, Christopher M Counter, Donald T Fox
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009228 (2020)
Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved Ras/mitogen-activated-protein-kinase (MAPK) pathway, which exhibits context-dependent signaling output dynamics and regula
Externí odkaz:
https://doaj.org/article/1f52412526d54987811d70aa950d6506
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167205 (2016)
The gene KRAS is commonly mutated in lung cancer to encode a constitutively active and oncogenic protein that is well established to initiate and maintain lung tumorigenesis. However, the remaining wild-type KRAS protein, or the other family members
Externí odkaz:
https://doaj.org/article/1950c509bf3e426d9cc61021ce7875cc
Autor:
Lawrence B Schook, Tiago V Collares, Wenping Hu, Ying Liang, Fernanda M Rodrigues, Laurie A Rund, Kyle M Schachtschneider, Fabiana K Seixas, Kuldeep Singh, Kevin D Wells, Eric M Walters, Randall S Prather, Christopher M Counter
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0128864 (2015)
The large size of the pig and its similarity in anatomy, physiology, metabolism, and genetics to humans make it an ideal platform to develop a genetically defined, large animal model of cancer. To this end, we created a transgenic "oncopig" line enco
Externí odkaz:
https://doaj.org/article/7699fe6d39c44c618c845089e7759100
Autor:
Jamie D Weyandt, Benjamin L Lampson, Sherry Tang, Matthew Mastrodomenico, Diana M Cardona, Christopher M Counter
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140253 (2015)
Oncogenic, activating mutations in KRAS initiate pancreatic cancer. There are, however, two other Ras family members, Nras and Hras, which can be activated in the presence of oncogenic Kras. The role of these wild-type Ras proteins in cancer remains
Externí odkaz:
https://doaj.org/article/783c7146ac1a429089962cbbbdc37118
Autor:
Lu Huang, Christopher M Counter
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123918 (2015)
In many different human cancers, one of the HRAS, NRAS, or KRAS genes in the RAS family of small GTPases acquires an oncogenic mutation that renders the encoded protein constitutively GTP-bound and thereby active, which is well established to promote
Externí odkaz:
https://doaj.org/article/3015d4b4ecc149d186d286a43193a0e9