Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Christopher M, Yip"'
Autor:
Hongxian Zhu, Andrew M. Sydor, Kirsten C. Boddy, Etienne Coyaud, Estelle M. N. Laurent, Aaron Au, Joel M. J. Tan, Bing-Ru Yan, Jason Moffat, Aleixo M. Muise, Christopher M. Yip, Sergio Grinstein, Brian Raught, John H. Brumell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection1. The effectors modulate host cell machinery to drive uptake of the bacteria into vacuoles, where they can establish
Externí odkaz:
https://doaj.org/article/cb972bdf39654deca965043e86fecd62
Autor:
Yu-Xi Xiao, Seon Yong Lee, Magali Aguilera-Uribe, Reuben Samson, Aaron Au, Yukti Khanna, Zetao Liu, Ran Cheng, Kamaldeep Aulakh, Jiarun Wei, Adrian Granda Farias, Taylor Reilly, Saba Birkadze, Andrea Habsid, Kevin R. Brown, Katherine Chan, Patricia Mero, Jie Qi Huang, Maximilian Billmann, Mahfuzur Rahman, Chad Myers, Brenda J. Andrews, Ji-Young Youn, Christopher M. Yip, Daniela Rotin, W. Brent Derry, Julie D. Forman-Kay, Alan M. Moses, Iva Pritišanac, Anne-Claude Gingras, Jason Moffat
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114417- (2024)
Summary: The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1 in regulating ce
Externí odkaz:
https://doaj.org/article/6cfa9d4fad5f4dfe962cefa4d0b2f79f
Autor:
Lei Jin, Ziyang Yu, Aaron Au, Peter Serles, Nan Wang, Jeremy T. Lant, Tobin Filleter, Christopher M. Yip
Publikováno v:
HardwareX, Vol 17, Iss , Pp e00508- (2024)
We present the design of a low-cost, portable telecentric digital holographic microscope (P-TDHM) that utilizes off-the-shelf components. We describe the system’s hardware and software elements and evaluate its performance by imaging samples rangin
Externí odkaz:
https://doaj.org/article/2cb610f9a60247ac90375345c16e8040
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102745- (2023)
Summary: Mitochondrial morphology is an indicator of cellular health and function; however, its quantification and categorization into different subclasses is a complicated process. Here, we present a protocol for mitochondrial morphology quantificat
Externí odkaz:
https://doaj.org/article/57022801fcad4de5b77664037dfdafc2
Autor:
Sudeshna Nag, Kaitlin Szederkenyi, Olena Gorbenko, Hannah Tyrrell, Christopher M. Yip, G. Angus McQuibban
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112895- (2023)
Summary: Mitochondrial morphology is regulated by the post-translational modifications of the dynamin family GTPase proteins including mitofusin 1 (MFN1), MFN2, and dynamin-related protein 1 (DRP1). Mitochondrial phosphatase phosphoglycerate mutase 5
Externí odkaz:
https://doaj.org/article/0b91a0e048ae469d8f491581d001ba5d
Autor:
Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrop
Externí odkaz:
https://doaj.org/article/aafde2c6ca28412ea8f19a14b47c1f34
Autor:
Sean Harrington, Jessica J. Knox, Andrew R. Burns, Ken-Loon Choo, Aaron Au, Megan Kitner, Cecile Haeberli, Jacob Pyche, Cassandra D’Amata, Yong-Hyun Kim, Jonathan R. Volpatti, Maximillano Guiliani, Jamie Snider, Victoria Wong, Bruna M. Palmeira, Elizabeth M. Redman, Aditya S. Vaidya, John S. Gilleard, Igor Stagljar, Sean R. Cutler, Daniel Kulke, James J. Dowling, Christopher M. Yip, Jennifer Keiser, Inga Zasada, Mark Lautens, Peter J. Roy
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A C. elegans-based screening approach identifies nementin as a nematode-selective nematicide that can be used synergistically with acetylcholinesterase inhibitors
Externí odkaz:
https://doaj.org/article/b2ae40e60cd44727b137593ac69b190f
Autor:
Romario Regeenes, Yufeng Wang, Anthony Piro, Aaron Au, Christopher M. Yip, Michael B. Wheeler, Jonathan V. Rocheleau
Publikováno v:
Biosensors and Bioelectronics: X, Vol 13, Iss , Pp 100285- (2023)
Pancreatic islets respond metabolically to glucose by closing KATP channels resulting in Ca2+-influx and insulin secretion. Previous work has revealed the importance of glycolytic flux in triggering insulin secretion. However, it is unclear whether t
Externí odkaz:
https://doaj.org/article/325b133c6cef4303aff514b5ee77096f
Autor:
Muntasir Kamal, Houtan Moshiri, Lilia Magomedova, Duhyun Han, Ken C. Q. Nguyen, May Yeo, Jessica Knox, Rachel Bagg, Amy M. Won, Karolina Szlapa, Christopher M. Yip, Carolyn L. Cummins, David H. Hall, Peter J. Roy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The C. elegans nematode worm is a filter-feeder and requires dietary sources of cholesterol. Here, the authors show that the C. elegans pharynx works as a filter to scavenge hydrophobic small molecules from its surrounding liquid environment.
Externí odkaz:
https://doaj.org/article/01ca567f548348c9ac82fe0b636300c0
Autor:
Christopher M. Yip
Publikováno v:
APL Bioengineering, Vol 5, Iss 1, Pp 010401-010401-4 (2021)
Externí odkaz:
https://doaj.org/article/4821c17e028c4834bb4caa29a798eb22