Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christopher M, Summa"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract As aquatic hypoxia worsens on a global scale, fishes will become increasingly challenged by low oxygen, and understanding the molecular basis of their response to hypoxia may help to better define the capacity of fishes to cope with this cha
Externí odkaz:
https://doaj.org/article/9c754f82ae274eb080f5fd339aeb57ed
Publikováno v:
Journal of chemical information and modeling. 61(2)
An implementation of the replica exchange with dynamical scaling (REDS) method in the commonly used molecular dynamics program GROMACS is presented. REDS is a replica exchange method that requires fewer replicas than conventional replica exchange whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec89c59c51fd3ab55047a07e25d9be2e
https://pubmed.ncbi.nlm.nih.gov/33496583
https://pubmed.ncbi.nlm.nih.gov/33496583
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46778 (2012)
BACKGROUND: Anti-HIV immunoconjugates targeted to the HIV envelope protein may be used to eradicate the latent reservoir of HIV infection using activate-and-purge protocols. Previous studies have identified the two target epitopes most effective for
Externí odkaz:
https://doaj.org/article/0fa64be01d944e73b5d1e3741cf19841
Autor:
Arthur L. Haas, Jennifer M. Klein, Elizabeth D. Kim, Christopher M. Summa, Virginia P. Ronchi
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ec5fe00af6f14cf961d6cc19c86f9d9
https://doi.org/10.1096/fasebj.2018.32.1_supplement.654.8
https://doi.org/10.1096/fasebj.2018.32.1_supplement.654.8
Autor:
Christopher M. Summa, Elizabeth D. Kim, Arthur L. Haas, Jennifer M. Klein, Virginia P. Ronchi
To understand the mechanism for assembly of Lys48-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin–binding sites: a high-affinity Site 1 required for E6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3326ed10fe985634041d840713009c
https://europepmc.org/articles/PMC5672028/
https://europepmc.org/articles/PMC5672028/
Autor:
Jonathan P. Redmann, David L. Mobley, Teng Lin, Nathan M. Lim, Vivian R. Jaber, Yujie Wu, Christopher M. Summa, Shuai Liu, Robert Abel
Publikováno v:
Journal of Computer-Aided Molecular Design. 27:755-770
Alchemical free energy calculations hold increasing promise as an aid to drug discovery efforts. However, applications of these techniques in discovery projects have been relatively few, partly because of the difficulty of planning and setting up cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c1898dbf7a5cdb6ad1a01ff3254edf
https://doi.org/10.1007/s10822-013-9678-y
https://doi.org/10.1007/s10822-013-9678-y
Autor:
Eric Morales, June A. D’Angelo, YongKeun Park, Edda Fiebiger, Bonny L. Dickinson, Kamran Badizadegan, Christopher M. Summa, Martha L. Aiken, Jone Garay
Publikováno v:
The Journal of Immunology. 185:3227-3238
The cAMP-dependent signaling pathways that orchestrate dendritic cell (DC) maturation remain to be defined in detail. Although cAMP was previously thought to signal exclusively through protein kinase A (PKA), it is now clear that cAMP also activates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a279ffaa52d091bd662cfbc7d9bf2b
https://doi.org/10.4049/jimmunol.0903066
https://doi.org/10.4049/jimmunol.0903066
Publikováno v:
Protein Science. 12:337-348
Membrane proteins and water-soluble proteins share a similar core. This similarity suggests that it should be possible to water-solubilize membrane proteins by mutating only their lipid-exposed residues. We have developed computational tools to desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151b0e1b33e0fe99347ec3eff357d24c
https://doi.org/10.1110/ps.0226603
https://doi.org/10.1110/ps.0226603
Autor:
Jae-Kyoung Hong, Michael M. Rosenblatt, Christopher M. Summa, James D. Lear, William F. DeGrado
Publikováno v:
Journal of Molecular Biology. 321:923-938
Diiron proteins are found throughout nature and have a diverse range of functions; proteins in this class include methane monooxygenase, ribonucleotide reductase, Delta(9)-acyl carrier protein desaturase, rubrerythrin, hemerythrin, and the ferritins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aca9277e6a8e1521857a5764400dc51
https://doi.org/10.1016/s0022-2836(02)00589-2
https://doi.org/10.1016/s0022-2836(02)00589-2
Publikováno v:
Journal of Molecular Biology. 311:1081-1090
Antiparallel helical bundles are found in a wide range of proteins. Often, four-helical bundles form tube-like structures, with binding sites for substrates or cofactors near their centers. For example, a transmembrane four-helical bundle in cytochro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e780687ee5bf802a4b1a40e31627e161
https://doi.org/10.1006/jmbi.2001.4900
https://doi.org/10.1006/jmbi.2001.4900