Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher M, Amantea"'
Autor:
Allister Fraser, Kevin R. Shreder, Junichi Ishiyama, John W. Kozarich, Yi Hu, Yasushi Kohno, Heidi E. Brown, Lingling Du, Eric Okerberg, Christopher M. Amantea, Julia Cajica, Emme C.K. Lin, Lan M. Pham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1553-1556
AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn2+-dependent, 27 nM inhibitor of human plasma Lp-PLA2. Structure–activity relationship studies focused on the AX10479 2-phenylamide gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c315b99f9891368e7cffabc5de59502a
https://doi.org/10.1016/j.bmcl.2012.11.048
https://doi.org/10.1016/j.bmcl.2012.11.048
Autor:
Helge Weissig, Shyama Sidique, John W. Kozarich, Emme C.K. Lin, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Junichi Ishiyama, Yi Hu, Bei Li, Christopher M. Amantea
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal, and tissue-restricted dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0e539b27866c3e1d8419d25b4f8e3
https://europepmc.org/articles/PMC5081620/
https://europepmc.org/articles/PMC5081620/
Autor:
Eric Okerberg, Julia Cajica, Kevin R. Shreder, Yasushi Kohno, Lan M. Pham, Heidi E. Brown, Junichi Ishiyama, Yi Hu, John W. Kozarich, Allister Fraser, Lingling Du, Emme C.K. Lin, Christopher M. Amantea
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:868-871
AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100 nM inhibitor of Lp-PLA2. However, in the presence of EDTA the inhibitory activity of AX10185 was extinguished while the enzymatic activity of Lp-PLA2 did not change. Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de185b106366a37c0bc14bd62e17a668
https://doi.org/10.1016/j.bmcl.2011.12.045
https://doi.org/10.1016/j.bmcl.2011.12.045
Autor:
Daniel Shouhed, Theodore J. Hahn, Hoa Ton Kha, Jennifer A. Richardson, Christopher M. Amantea, Farhad Parhami
Publikováno v:
Journal of Cellular Biochemistry. 95:1276-1283
The osleoporosis that occurs with aging is associated with reduced number and activity of osteoblastic cells. Aging, menopause, and osteoporosis are correlated with increased oxidative stress and reduced antioxidant defense mechanisms. We previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a235c59d08d288c6be6534d1620e6487
https://doi.org/10.1002/jcb.20497
https://doi.org/10.1002/jcb.20497
Autor:
Yi, Hu, Emme C K, Lin, Lan M, Pham, Julia, Cajica, Christopher M, Amantea, Eric, Okerberg, Heidi E, Brown, Allister, Fraser, Lingling, Du, Yasushi, Kohno, Junichi, Ishiyama, John W, Kozarich, Kevin R, Shreder
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn(2+)-dependent, 27nM inhibitor of human plasma Lp-PLA(2). Structure-activity relationship studies focused on the AX10479 2-phenylamide gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b34b44aa3a62c9cf8f531166843fd435
https://pubmed.ncbi.nlm.nih.gov/23333209
https://pubmed.ncbi.nlm.nih.gov/23333209
Autor:
Kevin R. Shreder, Jonathan S. Rosenblum, Allister Fraser, Ethel McGee, Christopher M. Amantea, Yi Hu, Emme C.K. Lin, Lan M. Pham, John W. Kozarich, Heidi E. Brown, De Michael Chung, Jiangyue Wu, Julia Cajica, Eric Okerberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
KIAA1363 is a serine hydrolase whose activity has been shown to be positively associated with tumor cell invasiveness. Thus, inhibitors of KIAA1363 represent a novel targeted therapy approach towards cancer. AX11890 ((1-bromo-2-naphthyl) N,N-dimethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c4de3cd2c577bc674e8522279d5de
https://pubmed.ncbi.nlm.nih.gov/22877630
https://pubmed.ncbi.nlm.nih.gov/22877630
Osteoporosis and its complications cause morbidity and mortality in the aging population, and result from increased bone resorption by osteoclasts in parallel with decreased bone formation by osteoblasts. A widely accepted strategy for improving bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bf7263def5be6a6bbca8b0f379010d
https://europepmc.org/articles/PMC2574814/
https://europepmc.org/articles/PMC2574814/
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 22(11)
Specific oxysterols have been shown to be pro-osteogenic and anti-adipogenic. However, the molecular mechanism(s) by which oxysterols inhibit adipogenic differentiation is unknown. We show that the anti-adipogenic effects of osteogenic oxysterol, 20(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dd8d19bb2a2f9fa9144eafa65a3e9f
https://pubmed.ncbi.nlm.nih.gov/17638575
https://pubmed.ncbi.nlm.nih.gov/17638575
Autor:
Catherine M. Cowan, Jennifer A. Richardson, Farhad Parhami, Tara Aghaloo, Christopher M. Amantea, Sotirios Tetradis, Ben M. Wu
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 25(11)
Oxysterols, naturally occurring cholesterol oxidation products, can induce osteoblast differentiation. Here, we investigated short-term 22(S)-hydroxycholesterol + 20(S)-hydroxycholesterol (SS) exposure on osteoblastic differentiation of marrow stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab457d26a6e8414e074b62d4110cf9b0
https://pubmed.ncbi.nlm.nih.gov/17568450
https://pubmed.ncbi.nlm.nih.gov/17568450
Autor:
Theodore J. Hahn, Farhad Parhami, Jennifer A. Richardson, Christopher M. Amantea, Sotirios Tetradis, Benjamin Kianmahd, Jay R. Lieberman
Publikováno v:
Journal of cellular biochemistry. 100(5)
Oxysterols form a large family of oxygenated derivatives of cholesterol that are present in circulation, and in human and animal tissues. The discovery of osteoinductive molecules that can induce the lineage-specific differentiation of cells into ost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67117ff9fe17717192042e16b319606c
https://pubmed.ncbi.nlm.nih.gov/17031848
https://pubmed.ncbi.nlm.nih.gov/17031848