Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Christopher M, Adams"'
Autor:
Sarah H. Bjorkman, Alex Marti, Jayashree Jena, Luis Miguel García-Peña, Eric T. Weatherford, Kevin Kato, Jivan Koneru, Jason Chen, Ayushi Sood, Matthew J. Potthoff, Christopher M. Adams, E. Dale Abel, Renata O. Pereira
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is requ
Externí odkaz:
https://doaj.org/article/438fdd6b7f334f3d84b2767d8e8eb602
Autor:
Davy Vanhoutte, Tobias G. Schips, Rachel A. Minerath, Jiuzhou Huo, Naga Swathi Sree Kavuri, Vikram Prasad, Suh-Chin Lin, Michael J. Bround, Michelle A. Sargent, Christopher M. Adams, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114149- (2024)
Summary: Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle atrophy with age-dependent decreases in exercise capacity and prema
Externí odkaz:
https://doaj.org/article/cbb8ebd5e51b4718a055bc0a6afa780b
Autor:
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle–specific expres
Externí odkaz:
https://doaj.org/article/af1307b64c1b4419953e38f85ed47944
Autor:
Scott M. Ebert, Celine S. Nicolas, Paul Schreiber, Jaime G. Lopez, Alan T. Taylor, Andrew R. Judge, Sarah M. Judge, Blake B. Rasmussen, John J. Talley, Christophe A. Rème, Christopher M. Adams
Publikováno v:
Animals, Vol 14, Iss 2, p 186 (2024)
Muscle atrophy and weakness are prevalent and debilitating conditions in dogs that cannot be reliably prevented or treated by current approaches. In non-canine species, the natural dietary compound ursolic acid inhibits molecular mechanisms of muscle
Externí odkaz:
https://doaj.org/article/493b01afca24468aa78b04e49c41e4a3
Autor:
Neil G. Rumachik, Stacy A. Malaker, Nicole Poweleit, Lucy H. Maynard, Christopher M. Adams, Ryan D. Leib, Giana Cirolia, Dennis Thomas, Susan Stamnes, Kathleen Holt, Patrick Sinn, Andrew P. May, Nicole K. Paulk
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 98-118 (2020)
Different approaches are used in the production of recombinant adeno-associated virus (rAAV). The two leading approaches are transiently transfected human HEK293 cells and live baculovirus infection of Spodoptera frugiperda (Sf9) insect cells. Unexpl
Externí odkaz:
https://doaj.org/article/5bf725043a6b4f7f9442d02c1d0f7c87
Autor:
Vanessa Byles, Yann Cormerais, Krystle Kalafut, Victor Barrera, James E. Hughes Hallett, Shannan Ho Sui, John M. Asara, Christopher M. Adams, Gerta Hoxhaj, Issam Ben-Sahra, Brendan D. Manning
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101309- (2021)
Objective: The mechanistic target of rapamycin complex 1 (mTORC1) is dynamically regulated by fasting and feeding cycles in the liver to promote protein and lipid synthesis while suppressing autophagy. However, beyond these functions, the metabolic r
Externí odkaz:
https://doaj.org/article/9bc1252e0f6b4fe8816ee31294ba42c1
Autor:
Renata O Pereira, Alex Marti, Angela Crystal Olvera, Satya Murthy Tadinada, Sarah Hartwick Bjorkman, Eric Thomas Weatherford, Donald A Morgan, Michael Westphal, Pooja H Patel, Ana Karina Kirby, Rana Hewezi, William Bùi Trân, Luis Miguel García-Peña, Rhonda A Souvenir, Monika Mittal, Christopher M Adams, Kamal Rahmouni, Matthew J Potthoff, E Dale Abel
Publikováno v:
eLife, Vol 10 (2021)
Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct mechanisms linking OPA1 to brown adipose tissue (BAT) physiology are incompletely understood.
Externí odkaz:
https://doaj.org/article/c6e3dfd170734862af6b78cb638840db
Autor:
J Aaron Crapster, Paul G Rack, Zane J Hellmann, Austen D Le, Christopher M Adams, Ryan D Leib, Joshua E Elias, John Perrino, Barry Behr, Yanfeng Li, Jennifer Lin, Hong Zeng, James K Chen
Publikováno v:
eLife, Vol 9 (2020)
Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here that h
Externí odkaz:
https://doaj.org/article/69dfb573f1c24a229b2802b43e4df09a
Publikováno v:
Kidney360
Heme proteins, the stuff of life, represent an ingenious biologic strategy that capitalizes on the biochemical versatility of heme, and yet is one that avoids the inherent risks to cellular vitality posed by unfettered and promiscuously reactive heme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386598dcb9b2dbbe80b7a6099a5a60e0
https://doi.org/10.34067/kid.0005442022
https://doi.org/10.34067/kid.0005442022
Autor:
Raman Deep Singh, Anthony J. Croatt, Allan W. Ackerman, Joseph P. Grande, Eugenia Trushina, Jeffrey L. Salisbury, Trace A. Christensen, Christopher M. Adams, Tamara Tchkonia, James L. Kirkland, Karl A. Nath
Publikováno v:
Kidney360
BACKGROUND: Mitochondrial injury occurs in and underlies acute kidney injury (AKI) caused by ischemia-reperfusion and other forms of renal injury. However, to date, a comprehensive analysis of this issue has not been undertaken in heme protein–indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faa43e71795599bfd5dc3cbc6faee88
https://doi.org/10.34067/kid.0004832022
https://doi.org/10.34067/kid.0004832022