Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Christopher Lademacher"'
Autor:
Tsutomu Takeuchi, Yoshiya Tanaka, Jay Erdman, Yuichiro Kaneko, Masako Saito, Chieri Higashitani, Ronald Smulders, Christopher Lademacher
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Abstract Background Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune condition characterized by joint synovial inflammation. Current treatments include methotrexate (MTX), biologic agents, and Janus kinase (JAK) inhibitors. However, th
Externí odkaz:
https://doaj.org/article/436bfbc159f642d981ede8a66257059d
Autor:
Per Ljungman, Arancha Bermudez, Aaron C. Logan, Mohamed A. Kharfan-Dabaja, Patrice Chevallier, Rodrigo Martino, Gerald Wulf, Dominik Selleslag, Kazuhiko Kakihana, Amelia Langston, Dong-Gun Lee, Carlos Solano, Shinichiro Okamoto, Larry R. Smith, Michael Boeckh, John R. Wingard, Beth Cywin, Christine Fredericks, Christopher Lademacher, Xuegong Wang, James Young, Johan Maertens
Publikováno v:
EClinicalMedicine, Vol 33, Iss , Pp 100787- (2021)
Background: Cytomegalovirus (CMV) is a complication of allogeneic haematopoietic cell transplantation (allo-HCT). ASP0113, a DNA-based vaccine, contains two plasmids encoding human CMV glycoprotein B and phosphoprotein 65 (pp65). We assessed ASP0113
Externí odkaz:
https://doaj.org/article/4c9a1e46498040168ace2f7c9223041e
Autor:
Leticia Delgado-Herrera, Kathryn Lasch, Bernhardt Zeiher, Anthony J. Lembo, Douglas A. Drossman, Benjamin Banderas, Kathleen Rosa, Christopher Lademacher, Rob Arbuckle
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 10 (2017)
Background: To evaluate the psychometric properties of the newly developed seven-item Irritable Bowel Syndrome – Diarrhea predominant (IBS-D) Daily Symptom Diary and four-item Event Log using phase II clinical trial safety and efficacy data in pati
Externí odkaz:
https://doaj.org/article/bfd1101049874f3cba6d93c94820cdff
Autor:
Jean Combalbert, Dirk Timmerman, Bart C.J.M. Fauser, Joop S.E. Laven, Graeme Fraser, Hamid R. Hoveyda, Axelle Pintiaux, Barbara Obermayer-Pietsch, Steven Ramael, Georg Griesinger, Christopher Lademacher
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 106(9), E3519-E3532. Endocrine Society
Context Polycystic ovary syndrome (PCOS), a highly prevalent endocrine disorder characterized by hyperandrogenism, is the leading cause of anovulatory infertility. Objective This proof-of-concept study evaluated clinical efficacy and safety of the ne
Autor:
Kanji Komatsu, Tsutomu Takeuchi, Chieri Higashitani, Christopher Lademacher, Megumi Iwai, Rio Akazawa, Yoshiya Tanaka
Publikováno v:
Modern Rheumatology. 31:53-60
Many patients with rheumatoid arthritis (RA) are not able to achieve long-term disease remission. This phase 2a study (NCT02884635) evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of the novel, oral, gonadotropin-releasing horm
Autor:
J. Christopher Day, Haydar Frangoul, Christopher Lademacher, Lara Danziger-Isakov, William J Muller, Inci Yildirim, Amit Desai, William J. Steinbach, Mark E. Jones, Julie Chu, Paul K. Sue, Laura L. Kovanda, Tempe K. Chen, Susan R. Rheingold, Dwight E Yin, Michael Neely, Thomas J. Walsh, Antonio Arrieta, Victoria A. Statler, Desiree Leiva Phillips, Kelley Micklus, Grace A. McComsey, Kamal Hamed
Publikováno v:
Antimicrobial Agents and Chemotherapy
Isavuconazole, administered as the water-soluble prodrug isavuconazonium sulfate, is a new triazole agent used to treat invasive fungal infections. This phase 1 study evaluated the pharmacokinetics (PK), safety, and tolerability of isavuconazole in 4
Autor:
David T Bolong, Achim Steup, Nancy Martin, Christopher Lademacher, Cristian Persu, Camilla Tøndel, Malgorzata Baka-Ostrowska
Publikováno v:
Neurourology and Urodynamics
Aims To evaluate the efficacy and safety of mirabegron in children and adolescents (aged 3 to
Autor:
Teresa Flegel, Christopher Lademacher, Jay Erdman, Alexander Weidemann, Misun Lee, Pierre Merville, Flavio Vincenti, Kate Wyburn, Elisabeth Cassuto-Viguier, Xuegong Wang, Fuad S. Shihab, Klemens Budde, V. Ram Peddi, Malay B. Shah
Publikováno v:
American Journal of Transplantation. 18:2945-2954
Cytomegalovirus (CMV) is a latent infection in most infected individuals, but can be pathogenic in immunocompromised kidney transplant recipients. ASP0113 is a DNA-based vaccine for the prevention of CMV-related mortality and end-organ disease in tra
Publikováno v:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Introduction: Although international clinical practice guidelines recognize a continued role for menopausal hormone therapy (HT), particularly for symptomatic women
Autor:
Xuegong Wang, Per Ljungman, Carlos Solano, Christopher Lademacher, Gerald Wulf, Michael Boeckh, Christine Fredericks, Dominik Selleslag, Dong-Gun Lee, Rodrigo Martino, Amelia Langston, Larry R. Smith, John R. Wingard, Shinichiro Okamoto, Arancha Bermúdez, Aaron C Logan, James Young, Mohamed A. Kharfan-Dabaja, Johan Maertens, Kazuhiko Kakihana, Beth Cywin, Patrice Chevallier
Publikováno v:
EClinicalMedicine, Vol 33, Iss, Pp 100787-(2021)
EClinicalMedicine
EClinicalMedicine, 2021, 33, pp.100787. ⟨10.1016/j.eclinm.2021.100787⟩
EClinicalMedicine
EClinicalMedicine, 2021, 33, pp.100787. ⟨10.1016/j.eclinm.2021.100787⟩
BACKGROUND: Cytomegalovirus (CMV) is a complication of allogeneic haematopoietic cell transplantation (allo-HCT). ASP0113, a DNA-based vaccine, contains two plasmids encoding human CMV glycoprotein B and phosphoprotein 65 (pp65). We assessed ASP0113