Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christopher L. Millington"'
Autor:
Sally B. Morton, L. David Finger, Roxanne van der Sluijs, William D. Mulcrone, Michael Hodskinson, Christopher L. Millington, Christina Vanhinsbergh, Ketan J. Patel, Mark J. Dickman, Puck Knipscheer, Jane A. Grasby, David M. Williams
Publikováno v:
Journal of the American Chemical Society.
DNA interstrand cross-links (ICLs) prevent DNA replication and transcription and can lead to potentially lethal events, such as cancer or bone marrow failure. ICLs are typically repaired by proteins within the Fanconi Anemia (FA) pathway, although th
Autor:
Etsuro Ito, Seiji Kojima, Kenichi Yoshida, Rui Yu, Camille Nadler, Paul S. Monks, Asuka Hira, Nicola K. Wilson, Motohiro Kato, Ashley N. Kamimae-Lanning, Satoru Miyano, Hiromasa Yabe, Tomoo Osumi, Minako Mori, Miharu Yabe, Michael R. G. Hodskinson, Minoru Takata, Hideki Muramatsu, Lucas B. Pontel, Seishi Ogawa, Toshinori Moriguchi, Christopher L. Millington, Yusuke Okamoto, Masayuki Kobayashi, Yuichi Shiraishi, Meng Wang, Ketan J. Patel, Frederic Langevin, Berthold Göttgens, Yusuke Okuno, Sam Watcham, Felix A. Dingler, Rebecca Cordell, Keitaro Matsuo, Nina Oberbeck, Anfeng Mu
Publikováno v:
Molecular Cell
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Summary Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly shortened lifes
Autor:
David M. Williams, Christopher L. Millington, Barbara van Loon, Michael H. Räz, Hannah R. Dexter, Shana J. Sturla
Publikováno v:
Chemical Research in Toxicology
The generation of chemical alkylating agents from nitrosation of glycine and bile acid conjugates in the gastrointestinal tract is hypothesized to initiate carcinogenesis. O(6)-carboxymethylguanine (O(6)-CMG) is a product of DNA alkylation derived fr
Autor:
Masaru Tsunoda, Christopher L. Millington, Yuji Kikuchi, David M. Williams, Oliver J. Wilkinson, Geoffrey P. Margison, Akio Takénaka, Fang Zhang
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:1669-1679
N-Nitrosation of glycine and its derivatives generates potent alkylating agents that can lead to the formation ofO6-carboxymethylguanine (O6-CMG) in DNA.O6-CMG has been identified in DNA derived from human colon tissue and its occurrence has been lin
Autor:
Julie L. Tubbs, Geoffrey P. Margison, Bernard A. Connolly, Hannah Blackburn, Christopher L. Millington, Mary R Thorncroft, David M. Williams, Oliver J. Wilkinson, Christopher A. Hunter, John A. Tainer, Andrew S. Marriott, Rihito Morita, Gail McGown, Ryoji Masui, Jane A. Grasby, Vitaly F. Latypov, Amanda J. Watson
Publikováno v:
Proceedings of the National Academy of Sciences. 109:18755-18760
Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA alkylation damage by flagging O 6 -alkylguanine lesions for nucleotide excision repair (NER). We s
Autor:
Julie L. Tubbs, Gail McGown, Andrew S. Arvai, Mary R Thorncroft, Amanda J. Watson, Oliver J. Wilkinson, Christopher L. Millington, Vitaly F. Latypov, Pattama Senthong, John A. Tainer, Andrew S. Marriott, Andrew C. Povey, David M. Williams, Geoffrey P. Margison, Amna Butt, Mauro Santibanez-Koref
Publikováno v:
Molecular Cell. 47(1):50-60
Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by chemical carcinogens, and the molecular mechanism has been partially elucidated. Here we demonstrate that in Schizosaccharomyces pombe a DNA recognition protein, al
Autor:
Christopher L. Millington, Akio Takénaka, Akihiro Ohkubo, Tsuyoshi Haraguchi, Taizo Kurose, Takayuki Shibata, Xiao Ma, David M. Williams, Satoru Shimizu, Fang Zhang, M. Tsunoda, Mitsuo Sekine, Ella Czarina Magat Juan
Publikováno v:
Nucleic Acids Research
The incorporation of the bicyclic cytosine analogue 7,8-dihydropyrido[2,3-d]pyrimidin-2-one (X) into DNA duplexes results in a significant enhancement of their stability (3-4 K per modification). To establish the effects of X on the local hydrogen-bo
Autor:
Andrew S. Arvai, Geoffrey P. Margison, Lisa A. Peterson, Rolf Kraehenbuehl, Vitaly F. Latypov, Sreenivas Kanugula, Matthew D Kroeger, Julie L. Tubbs, Mary R Thorncroft, Gail McGown, David M. Williams, Manana Melikishvili, Oliver Fleck, Christopher L. Millington, John A. Tainer, Barbara Verbeek, Anthony E. Pegg, Andrew S. Marriott, Amanda J. Watson, Amna Butt, Michael Fried, Mauro Santibanez-Koref
Publikováno v:
Nature. 459:808-813
Alkyltransferase-like proteins (ATLs) share functional motifs with the cancer chemotherapy target O6-alkylguanine-DNA alkyltransferase (AGT) and paradoxically protect cells from the biological effects of DNA alkylation damage, despite lacking the rea
Autor:
Fang, Zhang, Masaru, Tsunoda, Yuji, Kikuchi, Oliver, Wilkinson, Christopher L, Millington, Geoffrey P, Margison, David M, Williams, Akio, Takénaka
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 70(Pt 6)
N-Nitrosation of glycine and its derivatives generates potent alkylating agents that can lead to the formation of O(6)-carboxymethylguanine (O(6)-CMG) in DNA. O(6)-CMG has been identified in DNA derived from human colon tissue and its occurrence has
Autor:
David R. Williams, Mary R Thorncroft, Christopher A. Hunter, John A. Tainer, Julie L. Tubbs, Andrew S. Marriott, Vitaly F. Latypov, Jane A. Grasby, Bernard A. Connolly, Amanda J. Watson, Christopher L. Millington, Hannah Blackburn, Geoffrey P. Margison, Rihito Morita, Oliver J. Wilkinson, Gail McGown, Ryoji Masui
Publikováno v:
Collection Symposium Series.