Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christopher L. Lord"'
Publikováno v:
Cell Reports. 41:111590
SUMMARYThe origin recognition complex (ORC) binds throughout the genome to initiate DNA replication. In metazoans, it is still unclear how ORC is targeted to specific loci to facilitate helicase loading and replication initiation. Here, we performed
Autor:
Austin L. Ivey, Pate S. Hill, Yihu Xie, Yi Ren, Bradley P. Clarke, W. Hayes McDonald, Susan R. Wente, Christopher L. Lord
Publikováno v:
Proc Natl Acad Sci U S A
The C-terminal domain (CTD) kinase I (CTDK-1) complex is the primary RNA Polymerase II (Pol II) CTD Ser2 kinase in budding yeast. CTDK-1 consists of a cyclin-dependent kinase (CDK) Ctk1, a cyclin Ctk2, and a unique subunit Ctk3 required for CTDK-1 ac
Autor:
Susan R. Wente, Christopher L. Lord
The intricacy of nuclear pore complex (NPC) biogenesis imposes risks of failure that can cause defects in nuclear transport and nuclear envelope morphology, however, cellular mechanisms utilized to alleviate NPC assembly stress are not well-defined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81296b2abfdeab8ce661dbe678016728
Publikováno v:
RNA. 23:365-377
Nuclear pore complexes (NPCs), which are composed of nucleoporins (Nups) and regulate transport between the nucleus and cytoplasm, significantly impact the replicative life span (RLS) of Saccharomyces cerevisiae. We previously reported that deletion
Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae
Publikováno v:
The Journal of Cell Biology
Specific nucleoporins and nuclear pore complex–dependent transport events directly influence aging in yeast.
The eukaryotic nuclear permeability barrier and selective nucleocytoplasmic transport are maintained by nuclear pore complexes (NPCs),
The eukaryotic nuclear permeability barrier and selective nucleocytoplasmic transport are maintained by nuclear pore complexes (NPCs),
Autor:
Kevin Thorsen, Jinzhong Zhang, Susan Ferro-Novick, Kevin D. Corbett, Jared R. Helm, Deepali Bhandari, Christopher L. Lord, Shekar Menon, Shuliang Chen, Jesse C. Hay
Publikováno v:
Molecular Biology of the Cell
Previous studies show that the COPII coat is phosphorylated. The phosphorylated coat, however, cannot rebind to the ER to initiate a new round of vesicle budding. The present study shows that Sit4p/PP6, a Ser/Thr phosphatase, dephosphorylates the COP
Publikováno v:
RNA (New York, N.Y.). 23(3)
Nuclear pore complexes (NPCs), which are composed of nucleoporins (Nups) and regulate transport between the nucleus and cytoplasm, significantly impact the replicative life span (RLS) of Saccharomyces cerevisiae. We previously reported that deletion
Autor:
Deborah C. Nycz, Susan Ferro-Novick, Christopher L. Lord, Jesse C. Hay, Majid Ghassemian, Pradipta Ghosh, Shekar Menon, Deepali Bhandari
Publikováno v:
Nature
How the directionality of vesicle traffic is achieved remains an important unanswered question in cell biology. The Sec23p/Sec24p coat complex sorts the fusion machinery (SNAREs) into vesicles as they bud from the endoplasmic reticulum (ER). Vesicle
Autor:
Eliana Marinari, Jenna L. Riffell, Christopher L. Lord, Marieke Aarts, Alan Ashworth, Christopher Torrence, Sara Costa-Cabral
Publikováno v:
Molecular Cancer Therapeutics. 12:B24-B24
Background: KRAS is among the most commonly mutated human cancer genes, and is mutated in approximately 20% of human tumors. In colorectal cancer KRAS mutation is a predictor of anti-EGFR treatment resistance and different KRAS mutations can lead to
Publikováno v:
Cold Spring Harbor Perspectives in Biology. 5:a013367-a013367
Protein egress from the endoplasmic reticulum (ER) is driven by a conserved cytoplasmic coat complex called the COPII coat. The COPII coat complex contains an inner shell (Sec23/Sec24) that sorts cargo into ER-derived vesicles and an outer cage (Sec1