Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christopher L. Daige"'
Autor:
Danlee Enzler, Annah S Rolig, James E. Wooldridge, Mark R. Sullivan, Christopher L. Daige, Scott W. Rowlinson, Jason F. Wiggins, Leslie Priddy, Giulia Agnello, Melissa J Kasiewicz, Matthew G. Vander Heiden, Jessica Van Cleef, Venkatesh Rajamanickam, William L. Redmond, Alexander Muir, Mark Badeaux
Publikováno v:
Cancer immunology research. 9(4)
Metabolic dysregulation is a hallmark of cancer. Many tumors exhibit auxotrophy for various amino acids, such as arginine, because they are unable to meet the demand for these amino acids through endogenous production. This vulnerability can be explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dec3846370bc05d82b8d67757213e2
https://pubmed.ncbi.nlm.nih.gov/33500272
https://pubmed.ncbi.nlm.nih.gov/33500272
Autor:
Jason F. Wiggins, Christopher L. Daige, Mark Badeaux, Scott W. Rowlinson, Leslie Priddy, Danlee Enzler, Giulia Agnello
Publikováno v:
Cancer Research. 78:869-869
Tumors unable to synthesize L-Arginine (arginine) due to decreased expression of enzymes of the arginine biosynthetic pathway show increased sensitivity to arginine depletion. Pegzilarginase (AEB1102) is a bioengineered human PEGylated arginase 1 wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::678be025158aeaa9e1804fa49d259953
https://doi.org/10.1158/1538-7445.am2018-869
https://doi.org/10.1158/1538-7445.am2018-869
Autor:
Jason F. Wiggins, Jane Zhao, David R. Brown, Christopher L. Daige, Terri Nelligan-Davis, Leslie Priddy
Publikováno v:
Molecular cancer therapeutics. 13(10)
miR34a is a tumor-suppressor miRNA that functions within the p53 pathway to regulate cell-cycle progression and apoptosis. With apparent roles in metastasis and cancer stem cell development, miR34a provides an interesting opportunity for therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5876936a39e5c099eb0c25f148a48639
https://pubmed.ncbi.nlm.nih.gov/25053820
https://pubmed.ncbi.nlm.nih.gov/25053820
Autor:
Chris Cho, Michael Omotola, Jason F. Wiggins, Christopher L. Daige, David F.M. Brown, Frank J. Slack, Phong Trang, Andreas G. Bader, Joanne B. Weidhaas
MicroRNAs (miRNAs) are emerging as potential cancer therapeutics, but effective delivery mechanisms to tumor sites are a roadblock to utility. Here we show that systemically delivered, synthetic miRNA mimics in complex with a novel neutral lipid emul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ca9575daa38527f7ef6a5734cf1519
https://europepmc.org/articles/PMC3129804/
https://europepmc.org/articles/PMC3129804/
Autor:
David R. Brown, Andreas G. Bader, Sarah Dysart, Neil Leatherbury, Paul Lammers, Christopher L. Daige, Jason F. Wiggins, Michael Omotola, Kevin Kelnar, Leslie Priddy, Jane Zhao, Jay Stoudemire
Publikováno v:
Cancer Research. 72:5636-5636
MicroRNA (miRNA) mimics have emerged as a novel class of therapeutics with promising anti-oncogenic activity. These mimics are modeled after naturally occurring tumor suppressor miRNAs that are ubiquitously expressed in normal cells but frequently sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09204f55746addc22e1b3873036424cf
https://doi.org/10.1158/1538-7445.am2012-5636
https://doi.org/10.1158/1538-7445.am2012-5636