Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Christopher L. Baker"'
Autor:
Olivier B. Poirion, Wulin Zuo, Catrina Spruce, Candice N. Baker, Sandra L. Daigle, Ashley Olson, Daniel A. Skelly, Elissa J. Chesler, Christopher L. Baker, Brian S. White
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-32 (2024)
Abstract Enhlink is a computational tool for scATAC-seq data analysis, facilitating precise interrogation of enhancer function at the single-cell level. It employs an ensemble approach incorporating technical and biological covariates to infer condit
Externí odkaz:
https://doaj.org/article/d0958acda13f4ce2a7cfa49c1a75dbc4
Autor:
Arya Afsahi, Christopher M. Silvestri, Allyson E. Moore, Carly F. Graham, Kaylyn Bacchiochi, Martine St-Jean, Christopher L. Baker, Robert G. Korneluk, Shawn T. Beug, Eric C. LaCasse, Jonathan L. Bramson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe genesis of SMAC mimetic drugs is founded on the observation that many cancers amplify IAP proteins to facilitate their survival, and therefore removal of these pathways would re-sensitize the cells towards apoptosis. It has become incre
Externí odkaz:
https://doaj.org/article/eb5ca895b54b482fb6cf4a6da61045ce
Autor:
Kevin X. Lau, Elizabeth A. Mason, Joshua Kie, David P. De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J. McConville, Andrew Keniry, Tamara Beck, Marnie E. Blewitt, Matthew E. Ritchie, Shalin H. Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L. Baker, Tracy C. McGarr, Christine A. Wells, Martin F. Pera
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Human pluripotent cells (hPSCs) in standard culture are similar to mouse epiblast cells, but heterogeneity within hPSC cultures complicates comparisons. Here the authors show that a subpopulation of hPSCs enriched for self-renewal capacity have disti
Externí odkaz:
https://doaj.org/article/1f87c566710a45a38bb6a81fc0b27bcc
Autor:
Jennifer Taher, Christopher L. Baker, Carmelle Cuizon, Hassan Masoudpour, Rianna Zhang, Sarah Farr, Mark Naples, Celine Bourdon, Zdenka Pausova, Khosrow Adeli
Publikováno v:
Molecular Metabolism, Vol 3, Iss 9, Pp 823-833 (2014)
Background/objectives: Fasting dyslipidemia is commonly observed in insulin resistant states and mechanistically linked to hepatic overproduction of very low density lipoprotein (VLDL). Recently, the incretin hormone glucagon-like peptide-1 (GLP-1) h
Externí odkaz:
https://doaj.org/article/c285b753e9aa4bbfac2aee97f60e7fdd
Autor:
Ksenia Bezverbnaya, Joanne A. Hammill, Derek Cummings, Bojana Bojovic, Bella Groisman, Christopher L. Baker, Craig Aarts, Danielle L. Hayes, Donna Rill, Stacey X. Xu, Andreas G. Bader, Christopher W. Helsen, Jonathan L. Bramson
Publikováno v:
Cytotherapy. 25:490-501
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::547661220b61c9473b056e6d54a5f9f5
https://doi.org/10.1016/j.jcyt.2023.01.002
https://doi.org/10.1016/j.jcyt.2023.01.002
Autor:
Christina M Kelliher, Randy Lambreghts, Qijun Xiang, Christopher L Baker, Jennifer J Loros, Jay C Dunlap
Publikováno v:
eLife, Vol 9 (2020)
Circadian clocks in fungi and animals are driven by a functionally conserved transcription–translation feedback loop. In Neurospora crassa, negative feedback is executed by a complex of Frequency (FRQ), FRQ-interacting RNA helicase (FRH), and casei
Externí odkaz:
https://doaj.org/article/6cfce1d501b044ee9a0e313098f88a94
Autor:
Olivier B. Poirion, Wulin Zuo, Catrina Spruce, Sandra L. Daigle, Ashley Olson, Daniel A. Skelly, Elissa J. Chesler, Christopher L. Baker, Brian S. White
Enhancers play a crucial role in regulating gene expression and their functional status can be queried with cell type precision using using single-cell (sc)ATAC-seq. To facilitate analysis of such data, we developed Enhlink, a novel computational app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1541d0d35cec316c7ebdc798b9c0d67b
https://doi.org/10.1101/2023.05.11.540453
https://doi.org/10.1101/2023.05.11.540453
Autor:
Selcan Aydin, Duy T. Pham, Tian Zhang, Gregory R. Keele, Daniel A. Skelly, Joao A. Paulo, Matthew Pankratz, Ted Choi, Steven P. Gygi, Laura G. Reinholdt, Christopher L. Baker, Gary A. Churchill, Steven C. Munger
Publikováno v:
Cell Genom
Genetic background drives phenotypic variability in pluripotent stem cells (PSCs). Most studies to date have used transcript abundance as the primary molecular readout of cell state in PSCs. We performed a comprehensive proteogenomics analysis of 190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65234a40df372a3c42124ce07488ba0
https://europepmc.org/articles/PMC10112288/
https://europepmc.org/articles/PMC10112288/
Autor:
S. Ronan Foley, Ksenia Bezverbnaya, Christopher L. Baker, Rebecca C. Turner, Jonathan L. Bramson, Jamie D. McNicol, Derek Cummings, Craig Aarts, Galina Denisova, Duane Moogk, Anthony F. Rullo, Michael Sun
Publikováno v:
Cytotherapy. 23:820-832
Background aims T cells engineered with synthetic receptors have delivered powerful therapeutic results for patients with relapsed/refractory hematologic malignancies. The authors have recently described the T-cell antigen coupler (TAC) receptor, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203bcaabecfde53c7b40e0c85e354e4e
https://doi.org/10.1016/j.jcyt.2021.05.007
https://doi.org/10.1016/j.jcyt.2021.05.007
Autor:
Anna L Tyler, Catrina Spruce, Romy Kursawe, Annat Haber, Robyn L Ball, Wendy A Pitman, Alexander D Fine, Narayanan Raghupathy, Michael Walker, Vivek M Philip, Christopher L Baker, J. Matthew Mahoney, Gary A. Churchill, Jennifer J Trowbridge, Michael L Stitzel, Kenneth Paigen, Petko M Petkov, Gregory W Carter
It is well established that epigenetic features, such as histone modifications and DNA methylation, are associated with variation in gene expression across cell types. Less well known is the extent to which epigenetic states vary across genetically d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64401d5023c67c4a301ed7a92a30a68
https://doi.org/10.1101/2022.11.02.514900
https://doi.org/10.1101/2022.11.02.514900