Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christopher L. Brummel"'
Autor:
Zhengqi Ye, Ramkumar Iyer, Annette Ferrari, Tiansheng Wang, Alice L. Erwin, M. Angela Tanudra, Christopher L Brummel, Hong Gao, Leonard R. Duncan, Hong Tsao
Publikováno v:
ACS infectious diseases. 4(9)
A general method for determining bacterial uptake of compounds independent of antibacterial activity would be a valuable tool in antibacterial drug discovery. LC-MS/MS assays have been described, but it has not been shown whether the data can be used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6bc4babe1baee4b3ed753a712f7433
https://pubmed.ncbi.nlm.nih.gov/29961312
https://pubmed.ncbi.nlm.nih.gov/29961312
Autor:
John Williams, Christopher L Brummel
Publikováno v:
Advanced LC-MS Applications in Bioanalysis. :194-208
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8531b1d96205d680ca9e58b3e3395ed
https://doi.org/10.4155/fseb2013.14.327
https://doi.org/10.4155/fseb2013.14.327
Autor:
Scott L. Harbeson, Christopher L. Brummel, Dario Doller, Julie F. Liu, Robert H. Silverman, Roger D. Tung
The use of deuterium substitution in an effort to produce kinetic isotope effects (KIEs) that favorably alter pharmacokinetics and metabolism in drug discovery has accelerated in the last decade. While the effects of deuteration remain highly experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2fbe425fc282af194b33f639572cfb
https://doi.org/10.1016/bs.armc.2017.08.010
https://doi.org/10.1016/bs.armc.2017.08.010
Publikováno v:
Rapid Communications in Mass Spectrometry. 26:659-669
RATIONALE It has been proposed that the increase in the instances of idiosyncratic adverse drug reactions (IADRs) and black box warnings may be attributed to the occurrence of reactive metabolites. Consequently, a high-throughput screen for reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3555eff7646698821fd19e0f2a88ddb3
https://doi.org/10.1002/rcm.6135
https://doi.org/10.1002/rcm.6135
Publikováno v:
Bioanalysis. 2:1627-1640
The acetonitrile shortage during 2008 to 2009 challenged bioanalytical scientists due to the ubiquitous role that acetonitrile plays in sample preparation and analysis. Replacement, reduction and reuse of acetonitrile were the core tenants behind eac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11940b6a0a6d315de9e9a7b81b2e7f2a
https://doi.org/10.4155/bio.10.76
https://doi.org/10.4155/bio.10.76
Autor:
Eric Block, Hui Huang, Minzhang Chen, Christopher Town, Scott A. Raybuck, Young Chun Jung, Francois Maltais, Chien Ma, Christopher L Brummel, Robert B. Perni, Hongying Gao, Rebecca S. Shawgo, Jerry Tanoury, David Howe, Nagraj Mani, Leena Laitinen, Shengkai Liao, Youssef L. Bennani, Hong Tsao, S Pazhanisamy, Mark N. Namchuk
Publikováno v:
Journal of Medicinal Chemistry. 52:7993-8001
Telaprevir 2 (VX-950), an inhibitor of the hepatitis C virus (HCV(a)) NS3-4A protease, is in phase 3 clinical trials. One of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3 (VRT-394), containing an inversion at the chiral center next to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1026c8ab8e4f24ba8a6ef16c25c45c80
https://doi.org/10.1021/jm901023f
https://doi.org/10.1021/jm901023f
Publikováno v:
Rapid Communications in Mass Spectrometry. 21:3683-3693
Rapid information on metabolic profiling is required to evaluate the structural liabilities of drug candidates in early drug discovery. In this study, a sensitive and rapid semi-quantitative method was developed to simultaneously monitor the drug can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e5236916f22a30e8505d485761b7f1
https://doi.org/10.1002/rcm.3257
https://doi.org/10.1002/rcm.3257
Autor:
David Messersmith, Harmon J. Zuccola, Thomas Hoock, Sudipta Mahajan, Christopher Town, M. Woods Wannamaker, Luke Oh, Jian Wang, James J. Black, Bin Fan, Pamela McCarthy, Francesco G. Salituro, Mark N. Namchuk, Christopher L Brummel, Valerie Marone, Warren Dorsch, Randy S. Bethiel, Mark W. Ledeboer, Edmund Harrington, Summer Halas, Dina Shlyakter, Lora Swenson, Cochran John E, Youssef L. Bennani, Arthur Rugg, David Howe, Albert C. Pierce, Shannon Dean, Marina Penney, Hui Huang, Tiansheng Wang, Gabriel Martinez-Botella, James K. Hogan, Ananthsrinivas Chakilam, Shengkai Liao, Michael J. Arnost, Kumkum Saxena, Luc J. Farmer, Scott A. Raybuck, Shi-Kai Tian, Dylan Jacobs, Leena Laitinen, Raymond J. Winquist
Publikováno v:
Journal of medicinal chemistry. 58(18)
While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a57998bf457ae6f3959a86c5e2312bb
https://pubmed.ncbi.nlm.nih.gov/26230873
https://pubmed.ncbi.nlm.nih.gov/26230873
Autor:
Christopher L. Brummel, M. E. Hemling, S. A. Carr, Stephen J. Benkovic, Walter Johnson, G. D. Roberts, D. Gaitanopoulos, Nicholas Winograd, John C. Vickerman, J. Weinstock
Publikováno v:
Analytical Chemistry. 68:237-242
Electrospray, matrix-assisted laser desorption, and time-of-flight secondary ion mass spectrometry have been explored as possible methods for the identification of active members of molecular combinatorial libraries. All three methods are found to yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05440ae22bd6a402bf307c7b7b908ff
https://doi.org/10.1021/ac950998u
https://doi.org/10.1021/ac950998u
Publikováno v:
International Journal of Mass Spectrometry and Ion Processes. 143:257-270
Static SIMS has shown itself to be a powerful tool for surface analysis with high chemical specificity. Because of the destructive nature of the sputtering process, high spatial resolution analysis (sub-200-nm regime) requires very high yields of emi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a18acbb8a1e58c07cc3730802183a7e
https://doi.org/10.1016/0168-1176(94)04121-m
https://doi.org/10.1016/0168-1176(94)04121-m