Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Christopher L Tinkle"'
Autor:
Marc Zuckermann, Chen He, Jared Andrews, Aditi Bagchi, Roketa Sloan-Henry, Brandon Bianski, Jia Xie, Yingzhe Wang, Nathaniel Twarog, Arzu Onar-Thomas, Kati J. Ernst, Lei Yang, Yong Li, Xiaoyan Zhu, Jennifer K. Ocasio, Kaitlin M. Budd, James Dalton, Xiaoyu Li, Divyabharathi Chepyala, Junyuan Zhang, Ke Xu, Laura Hover, Jordan T. Roach, Kenneth Chun-Ho Chan, Nina Hofmann, Peter J. McKinnon, Stefan M. Pfister, Anang A. Shelat, Zoran Rankovic, Burgess B. Freeman, Jason Chiang, David T. W. Jones, Christopher L. Tinkle, Suzanne J. Baker
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating the MET receptor tyrosine kinase often occur in infant
Externí odkaz:
https://doaj.org/article/c4e30eaef7d54080a0db2c1628bcebbf
Autor:
Chen He, Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin, Nathaniel Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn H. Kasper, Junyuan Zhang, Xiaoyu Li, James Dalton, Barbara Jonchere, Kimberly S. Mercer, Duane G. Currier, William Caufield, Yingzhe Wang, Jia Xie, Alberto Broniscer, Cynthia Wetmore, Santhosh A. Upadhyaya, Ibrahim Qaddoumi, Paul Klimo, Frederick Boop, Amar Gajjar, Jinghui Zhang, Brent A. Orr, Giles W. Robinson, Michelle Monje, Burgess B. Freeman III, Martine F. Roussel, Paul A. Northcott, Taosheng Chen, Zoran Rankovic, Gang Wu, Jason Chiang, Christopher L. Tinkle, Anang A. Shelat, Suzanne J. Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Patient-derived xenografts provide a resource for basic and translational cancer research. Here, the authors generate multiple pediatric high-grade glioma xenografts, use omics technologies to show that they are representative of primary tumours and
Externí odkaz:
https://doaj.org/article/879be8929790465bbe548678fef6db02
Autor:
Hillary R. Husband, Olivia Campagne, Chen He, Xiaoyan Zhu, Brandon M. Bianski, Suzanne J. Baker, Anang A. Shelat, Christopher L. Tinkle, Clinton F. Stewart
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 6, Pp 599-610 (2021)
Abstract Radiation therapy (RT) is currently the standard treatment for diffuse intrinsic pontine glioma (DIPG), the most common cause of death in children with brain cancer. A pharmacodynamic model was developed to describe the radiation‐induced t
Externí odkaz:
https://doaj.org/article/dcdd147b9c694915b7e24c87ce5c2132
Autor:
Jason Chiang, Alexander K. Diaz, Lydia Makepeace, Xiaoyu Li, Yuanyuan Han, Yimei Li, Paul Klimo, Frederick A. Boop, Suzanne J. Baker, Amar Gajjar, Thomas E. Merchant, David W. Ellison, Alberto Broniscer, Zoltan Patay, Christopher L. Tinkle
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-12 (2020)
Abstract Diffuse intrinsic pontine glioma (DIPG) is most commonly diagnosed based on imaging criteria, with biopsy often reserved for pontine tumors with imaging features not typical for DIPG (atypical DIPG, ‘aDIPG’). The histopathologic and mole
Externí odkaz:
https://doaj.org/article/2975b5b4fe224850879f46dfd3e6eae4
Autor:
Nathaniel R. Twarog, Nancy E. Martinez, Jessica Gartrell, Jia Xie, Christopher L. Tinkle, Anang A. Shelat
Publikováno v:
Data in Brief, Vol 38, Iss , Pp 107400- (2021)
This data set contains the data used in Twarog et al. (2021) to examine the robustness and utility of response surface models in drug combination analysis. It includes simulated experimental data for the evaluation of traditional index methods, as we
Externí odkaz:
https://doaj.org/article/0f5297878d7d4c1fb07793e0ab5d4051
Autor:
Anthony P. Y. Liu, Sandeep K. Dhanda, Tong Lin, Edgar Sioson, Aksana Vasilyeva, Brian Gudenas, Ruth G. Tatevossian, Sujuan Jia, Geoffrey Neale, Daniel C. Bowers, Tim Hassall, Sonia Partap, John R. Crawford, Murali Chintagumpala, Eric Bouffet, Geoff McCowage, Alberto Broniscer, Ibrahim Qaddoumi, Greg Armstrong, Karen D. Wright, Santhosh A. Upadhyaya, Anna Vinitsky, Christopher L. Tinkle, John Lucas, Jason Chiang, Daniel J. Indelicato, Robert Sanders, Paul Klimo, Frederick A. Boop, Thomas E. Merchant, David W. Ellison, Paul A. Northcott, Brent A. Orr, Xin Zhou, Arzu Onar-Thomas, Amar Gajjar, Giles W. Robinson
Publikováno v:
Acta Neuropathologica. 144:733-746
Methylation profiling has radically transformed our understanding of tumors previously called central nervous system primitive neuro-ectodermal tumors (CNS-PNET). While this marks a momentous step toward defining key differences, reclassification has
Autor:
Ryan J. Duchatel, Evangeline R. Jackson, Sarah G. Parackal, Claire Sun, Paul Daniel, Abdul Mannan, Izac J. Findlay, Dilana Staudt, Zacary P. Germon, Sandra Laternser, Dylan Kiltschewskij, Padraic S. Kearney, M. Fairuz, B. Jamaluddin, Alicia M. Douglas, Tyrone Beitaki, Mika Persson, Elizabeth E. Manning, Heather C. Murray, Nicole M. Verrills, David A. Skerrett-Byrne, Brett Nixon, Susan Hua, Valdes-Mora Fatima, Maria Tsoli, David S. Ziegler, Murray J. Cairns, Eric Raabe, Nicholas A. Vitanza, Carl Koschmann, Frank Alvaro, Christopher V. Dayas, Christopher L. Tinkle, David D. Eisenstat, Ron Firestein, Sabine Mueller, Javad Nazarian, Jason E. Cain, Matthew D. Dun
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma – DIPG), are uniformly fatal brain tumors that lack effective pharmacological treatment. Analysis of pooled CRISPR-Cas9 loss-of-function gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7761ac079918d3d90d3ed9557966419d
https://doi.org/10.1101/2023.04.17.537256
https://doi.org/10.1101/2023.04.17.537256
Autor:
Anang A. Shelat, Elizabeth A. Stewart, Sara M. Federico, Christopher L. Tinkle, Geoffrey Neale, Shondra M. Pruett-Miller, Shaina N. Porter, Jiyang Yu, Koon-Kiu Yan, Michele Connelly, Nathaniel Twarog, Hyekyung P. Cho, Jia Xie, Lauren Hoffmann, Kaley Blankenship, April Sykes, Natasha A. Sahr, Armita Bahrami, Michael R. Clay, Marcia Mellado-Largarde, Jessica Gartrell
Detailed methods, description of supplemental tables, and supplemental figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb8dadfb4f52e25036b299ca156af2d
https://doi.org/10.1158/1535-7163.22522210.v1
https://doi.org/10.1158/1535-7163.22522210.v1
Autor:
Anang A. Shelat, Elizabeth A. Stewart, Sara M. Federico, Christopher L. Tinkle, Geoffrey Neale, Shondra M. Pruett-Miller, Shaina N. Porter, Jiyang Yu, Koon-Kiu Yan, Michele Connelly, Nathaniel Twarog, Hyekyung P. Cho, Jia Xie, Lauren Hoffmann, Kaley Blankenship, April Sykes, Natasha A. Sahr, Armita Bahrami, Michael R. Clay, Marcia Mellado-Largarde, Jessica Gartrell
Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26081ffff7ddd9371bef48558700bc4
https://doi.org/10.1158/1535-7163.22522204
https://doi.org/10.1158/1535-7163.22522204
Autor:
Anang A. Shelat, Elizabeth A. Stewart, Sara M. Federico, Christopher L. Tinkle, Geoffrey Neale, Shondra M. Pruett-Miller, Shaina N. Porter, Jiyang Yu, Koon-Kiu Yan, Michele Connelly, Nathaniel Twarog, Hyekyung P. Cho, Jia Xie, Lauren Hoffmann, Kaley Blankenship, April Sykes, Natasha A. Sahr, Armita Bahrami, Michael R. Clay, Marcia Mellado-Largarde, Jessica Gartrell
Pediatric sarcomas represent a heterogeneous group of malignancies that exhibit variable response to DNA-damaging chemotherapy. Schlafen family member 11 protein (SLFN11) increases sensitivity to replicative stress and has been implicated as a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3642df1e192e68eb63d89a112bc7c624
https://doi.org/10.1158/1535-7163.c.6543307
https://doi.org/10.1158/1535-7163.c.6543307