Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Christopher L Reading"'
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32147 (2012)
HE3286, 17α-ethynyl-5-androstene-3β, 7β, 17β-triol, is a novel synthetic compound related to the endogenous sterol 5-androstene-3β, 7β, 17β-triol (β-AET), a metabolite of the abundant adrenal steroid dehydroepiandrosterone (DHEA). HE3286 has
Externí odkaz:
https://doaj.org/article/89d5626bc45c48658ff9f39f3aaf5951
Autor:
Ajay K Malik, Sophia Khaldoyanidi, Dominick L Auci, Scott C Miller, Clarence N Ahlem, Christopher L Reading, Theodore Page, James M Frincke
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13566 (2010)
5-Androstene-3β,7β,17β-triol (β-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblas
Externí odkaz:
https://doaj.org/article/21de21ebb4a84ea1a5f7386efa808f38
Publikováno v:
Neurodegenerative disease management. 11(4)
Recently, the roles of inflammation and insulin resistance in neurodegeneration have become better appreciated. NE3107, an oral small molecule, blood-brain permeable anti-inflammatory insulin sensitizer that binds extracellular signal-regulated kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d2bf7185488f496bdeb26e885a79c7
https://pubmed.ncbi.nlm.nih.gov/34251287
https://pubmed.ncbi.nlm.nih.gov/34251287
Autor:
Ferdinando Nicoletti, Ingrid Philippens, Paolo Fagone, Clarence N. Ahlem, Christopher L. Reading, James M. Frincke, Dominick L. Auci
Publikováno v:
Parkinson's Disease, Vol 2012 (2012)
17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and efficacy i
Externí odkaz:
https://doaj.org/article/87c6993dba6844f7a3e9081dda6e9584
Autor:
Clarence N. Ahlem, James M. Frincke, Steven K. White, Christopher L. Reading, Richard J. Trauger, Rajkumar Lakshmanaswamy
Publikováno v:
International Journal of Breast Cancer, Vol 2011 (2011)
N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats. We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in c
Externí odkaz:
https://doaj.org/article/0f37c0cee40646c3a2dc51e5385f8237
Autor:
Ferdinando Nicoletti, Dominick L. Auci, Katia Mangano, Jaime Flores-Riveros, Sonia Villegas, James M. Frincke, Christopher L. Reading, Halina Offner
Publikováno v:
Autoimmune Diseases, Vol 2010 (2010)
Androstenediol (androst-5-ene-3β,17β-diol; 5-AED), a natural adrenal steroid, has been shown to suppress experimental autoimmune encephalomyelitis (EAE) in female SJL/J mice. We here report that 5-AED limits inflammation and proinflammatory cytokin
Externí odkaz:
https://doaj.org/article/25ab705ba1be482a9786c6dc6e4b297b
Autor:
Jaime Flores-Riveros, Clarence N. Ahlem, Dwight R. Stickney, Daniel A. Destiche, James M. Frincke, William T. Cefalu, Christopher L. Reading
Publikováno v:
Obesity. 21:E343-E349
Objective To study the activity of HE3286 (17α-ethynylandrost-5-ene-3β,7β,17β-triol), an anti-inflammatory sterol that is active in models of obesity-induced inflammation and insulin resistance in high body mass index (BMI) subjects with impaired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3e8b538cb621ddc57b971d7ddecc12
https://doi.org/10.1002/oby.20207
https://doi.org/10.1002/oby.20207
Autor:
Christopher L. Reading, Clarence N. Ahlem, Ingrid Philippens, Ferdinando Nicoletti, James M. Frincke, Paolo Fagone, Dominick L. Auci
Publikováno v:
Parkinson's Disease. 2012:1-8
17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and efficacy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2a8970de874148c3c01c8898464108
https://doi.org/10.1155/2012/969418
https://doi.org/10.1155/2012/969418
Autor:
Simon Authier, Dwight R. Stickney, Nanette Onizuka-Handa, Christopher L. Reading, Charles Dowding, James M. Frincke, Armando Garsd
Publikováno v:
International Immunopharmacology. 7:500-505
We previously reported that five daily intramuscular doses of 5-androstenediol (AED), a naturally occurring adrenal steroid hormone, stimulated multilineage recovery of bone marrow in rhesus monkeys with radiation-induced myelosuppression after 4.0 G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83c467a07f6ec913c72b00d03501ba7
https://doi.org/10.1016/j.intimp.2006.12.005
https://doi.org/10.1016/j.intimp.2006.12.005
