Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christopher L Peatey"'
Autor:
Lisa M Rigby, Brian J Johnson, Gordana Rašić, Christopher L Peatey, Leon E Hugo, Nigel W Beebe, Gunter F Hartel, Gregor J Devine
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009121 (2021)
BackgroundThe development of insecticide resistance in mosquitoes can have pleiotropic effects on key behaviours such as mating competition and host-location. Documenting these effects is crucial for understanding the dynamics and costs of insecticid
Externí odkaz:
https://doaj.org/article/84a02629ffd642b3b5a93293de0b487c
Autor:
Rebecca E Watts, Anand Odedra, Louise Marquart, Lachlan Webb, Azrin N Abd-Rahman, Laura Cascales, Stephan Chalon, Maria Rebelo, Zuleima Pava, Katharine A Collins, Cielo Pasay, Nanhua Chen, Christopher L Peatey, Jörg J Möhrle, James S McCarthy
Publikováno v:
PLoS Medicine, Vol 17, Iss 8, p e1003203 (2020)
BackgroundArtemisinin resistance is threatening malaria control. We aimed to develop and test a human model of artemisinin-resistant (ART-R) Plasmodium falciparum to evaluate the efficacy of drugs against ART-R malaria.Methods and findingsWe conducte
Externí odkaz:
https://doaj.org/article/f0e834c76c4545578dd2dc713b5572d9
Autor:
Karen-Ann Gray, Karryn J Gresty, Nanhua Chen, Veronica Zhang, Clare E Gutteridge, Christopher L Peatey, Marina Chavchich, Norman C Waters, Qin Cheng
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157906 (2016)
Artemisinin-induced dormancy provides a plausible explanation for recrudescence following artemisinin monotherapy. This phenomenon shares similarities with cell cycle arrest where cyclin dependent kinases (CDKs) and cyclins play an important role.Tra
Externí odkaz:
https://doaj.org/article/e4e8b480e65f49d88f561c6bd5643513
Publikováno v:
Pest Management Science
BACKGROUND In urban environments, some of the most common control tools used against the mosquito disease vector Aedes aegypti are pyrethroid insecticides applied as aerosols, fogs or residual sprays. Their efficacy is compromised by patchy deploymen
Autor:
Christopher L. Peatey, Qin Cheng, Rebecca E. Watts, Paul J. Pickering, Michelle L. Gatton, James S. McCarthy, Nanhua Chen, Karen Anderson, Karryn Gresty
Publikováno v:
The Journal of Infectious Diseases. 223:1631-1638
Background Artemisinin monotherapy of Plasmodium falciparum infection is frequently ineffective due to recrudescence. Artemisinin-induced dormancy, shown in vitro and in animal models, provides a plausible explanation. To date, direct evidence of art
Autor:
Christopher L. Peatey, Leon E. Hugo, Gordana Rašić, Gunter Hartel, Lisa M. Rigby, Nigel W. Beebe, Brian J. Johnson, Gregor J. Devine
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009121 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background The development of insecticide resistance in mosquitoes can have pleiotropic effects on key behaviours such as mating competition and host-location. Documenting these effects is crucial for understanding the dynamics and costs of insectici
Autor:
Christopher L. Peatey, Nigel W. Beebe, Gregor J. Devine, Lisa M. Rigby, Gordana Rašić, Leon E. Hugo
Publikováno v:
Parasites & Vectors
Parasites & Vectors, Vol 13, Iss 1, Pp 1-12 (2020)
Parasites & Vectors, Vol 13, Iss 1, Pp 1-12 (2020)
Background Effective vector control measures are essential in a world where many mosquito-borne diseases have no vaccines or drug therapies available. Insecticidal tools remain the mainstay of most vector-borne disease management programmes, although
Autor:
James S. McCarthy, Paul M. Griffin, Cielo Pasay, Louise Marquart, Claire Y. T. Wang, Silvana Sekuloski, Rebecca Rockett, Christopher L. Peatey, Mark Baker, Peter O'Rourke, Jörg J. Möhrle, Suzanne L. Elliott
Publikováno v:
The Journal of Infectious Diseases
Background. Piperaquine, coformulated with dihydroartemisinin, is a component of a widely used artemisinin combination therapy. There is a paucity of data on its antimalarial activity as a single agent. Such data, if available, would inform selection
Autor:
Nicholas E. Timmins, Gregory S. Watson, Jolanta A. Watson, Marko Guenther, Katharine R. Trenholme, Lars Nielson, Christopher L. Peatey, Christopher L. Brown, Donald L. Gardiner
Publikováno v:
The Journal of Infectious Diseases. 208:1170-1174
Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation sh
Autor:
Christopher L. Peatey, Tina S. Skinner-Adams, Katharine R. Trenholme, Timothy MacDonald, James S. McCarthy, Katherine T. Andrews, Alice S. Butterworth, Nina Eickel, Donald L. Gardiner
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:1334-1337
The stage-specific antimalarial activities of a panel of antiretroviral protease inhibitors (PIs), including two nonpeptidic PIs (tipranavir and darunavir), were tested in vitro against Plasmodium falciparum . While darunavir demonstrated limited ant