Zobrazeno 1 - 10
of 488
pro vyhledávání: '"Christopher L H Huang"'
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do no
Externí odkaz:
https://doaj.org/article/27ffa265831142f6b7a441d2795d3526
Autor:
Qiang Wen, Rui Zhang, Kejun Ye, Jun Yang, Hangchuan Shi, Zhu Liu, Yangpeng Li, Ting Liu, Shiyu Zhang, Wanpei Chen, Jingjing Wu, Weichao Liu, Xiaoqiu Tan, Ming Lei, Christopher L.-H. Huang, Xianhong Ou
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge r
Externí odkaz:
https://doaj.org/article/7a7224d6282a486ca9a2c8a589c4d075
Autor:
Anne-Laure Leoni, Bruno Gavillet, Jean-Sébastien Rougier, Céline Marionneau, Vincent Probst, Solena Le Scouarnec, Jean-Jacques Schott, Sophie Demolombe, Patrick Bruneval, Christopher L H Huang, William H Colledge, Andrew A Grace, Hervé Le Marec, Arthur A Wilde, Peter J Mohler, Denis Escande, Hugues Abriel, Flavien Charpentier
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9298 (2010)
Loss-of-function mutations in SCN5A, the gene encoding Na(v)1.5 Na+ channel, are associated with inherited cardiac conduction defects and Brugada syndrome, which both exhibit variable phenotypic penetrance of conduction defects. We investigated the m
Externí odkaz:
https://doaj.org/article/cdbbe44739414c65b378bc6914b4ef64
Autor:
Federico Bertagna, Shiraz Ahmad, Rebecca Lewis, S. Ravi P. Silva, Johnjoe McFadden, Christopher L.-H. Huang, Hugh R. Matthews, Kamalan Jeevaratnam
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionThe loose-patch clamp technique was first developed and used in native amphibian skeletal muscle (SkM), offering useful features complementing conventional sharp micro-electrode, gap, or conventional patch voltage clamping. It demonstrate
Externí odkaz:
https://doaj.org/article/94e8beade09943b6a18bc501602977b3
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Cardiac arrhythmias cause significant morbidity and mortality and pose a major public health problem. They arise from disruptions in the normally orderly propagation of cardiac electrophysiological activation and recovery through successive cardiomyo
Externí odkaz:
https://doaj.org/article/5931e0cf47424e51a948af6be9c4a03b
Autor:
Joshua A. Morris, Oliver J. Bardsley, Samantha C. Salvage, Antony P. Jackson, Hugh R. Matthews, Christopher L-H. Huang
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Introduction: In addition to gap junction conduction, recent reports implicate possible ephaptic coupling contributions to action potential (AP) propagation between successive adjacent cardiomyocytes. Here, AP generation in an active cell, withdraws
Externí odkaz:
https://doaj.org/article/c07da66d15954f158d1d4733b176bd69
Autor:
Ying H. Huang, MMath, PhD, Jane V. Lyle, BSc, Anisa Shahira Ab Razak, BA, Manasi Nandi, BSc, PhD, Celia M. Marr, BVMS, MVM, PhD, DEIM, DipECEIM, FRCVS, Christopher L.-H. Huang, BA, BM, BCh, PhD, DM, MD, DSc, ScD, FRSB, Philip J. Aston, BSc, PhD, Kamalan Jeevaratnam, DAHP, DVM, MMedSC, PhD, FRCVS
Publikováno v:
Cardiovascular Digital Health Journal, Vol 3, Iss 2, Pp 96-106 (2022)
Background: Atrial fibrillation (AF) is a common cardiac arrhythmia in both human and equine populations. It is associated with adverse outcomes in humans and decreased athletic performance in both populations. Paroxysmal atrial fibrillation (PAF) pr
Externí odkaz:
https://doaj.org/article/8f50d0217e2343dcae7574277cb04b72
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract A finite element analysis modelled diffusional generation of steady-state Ca2+ microdomains within skeletal muscle transverse (T)-tubular-sarcoplasmic reticular (SR) junctions, sites of ryanodine receptor (RyR)-mediated SR Ca2+ release. It u
Externí odkaz:
https://doaj.org/article/48d31e6e90444a8f8b311e1a53fd6e0a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (I Na) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffei
Externí odkaz:
https://doaj.org/article/6f44123619ea4ddabbb1ac1ad20bffe5
Autor:
Esther Bonet-Luz, MMath, PhD, Jane V. Lyle, BSc, Christopher L.-H. Huang, MA, BMBCh, DM, DSc, PhD, MD, ScD, Yanmin Zhang, MD, PhD, Manasi Nandi, BSc, PhD, Kamalan Jeevaratnam, DAHP, DVM, MMedSC, PhD, MRCVS, Philip J. Aston, BSc, PhD
Publikováno v:
Heart Rhythm O2, Vol 1, Iss 5, Pp 368-375 (2020)
Background: Life-threatening arrhythmias resulting from genetic mutations are often missed in current electrocardiogram (ECG) analysis. We combined a new method for ECG analysis that uses all the waveform data with machine learning to improve detecti
Externí odkaz:
https://doaj.org/article/fce511eb313c4fd4a215e909aeff36ca