Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Christopher L Carpenter"'
Autor:
Xuqing Zhang, Mengyao Luo, Shamael R. Dastagir, Mellissa Nixon, Annie Khamhoung, Andrea Schmidt, Albert Lee, Naren Subbiah, Douglas C. McLaughlin, Christopher L. Moore, Mary Gribble, Nicholas Bayhi, Viral Amin, Ryan Pepi, Sneha Pawar, Timothy J. Lyford, Vikram Soman, Jennifer Mellen, Christopher L. Carpenter, Laurence A. Turka, Thomas J. Wickham, Tiffany F. Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Red blood cells (RBCs) have unique properties that have been exploited for therapeutic uses. Here the authors engineer RBCs to co-express tumor associated antigens on MHC I, 4-1BBL and IL-12, generating artificial antigen presenting cells that can in
Externí odkaz:
https://doaj.org/article/81c7237bdaba401f8b24431f73e5d95a
Autor:
Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. Mohammad
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD
Externí odkaz:
https://doaj.org/article/bb08125c1aa14689b48e6b606c7f9587
Autor:
Christopher L. Carpenter, Eldridge N. Nartey, Dominic Suarez, Elisabeth A. Minthorn, Jesus R. Medina, Louis V. LaFrance, Ralph A. Rivero, James F. Mack, Charles F. McHugh, Xinrong Tian, Dirk A. Heerding, Christina Ng Di Marco, Thomas J. Berrodin, Aishwarya Bhaskar, Biju Mangatt, William Hoi Hong Li, Brackley James, Martyr Cuthbert, Lorena A. Kallal, Michael Butticello, Jacob Rubin
Publikováno v:
Journal of Medicinal Chemistry. 64:16056-16087
Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacological inhibitors that directly target MYC have not yet yielded a drug-like molecule due to the lack of an
Autor:
Peter A. Jones, Ashley K. Wiseman, Helai P. Mohammad, Christopher S. Kershaw, Bryan W. King, Ian D. Waddell, Thau F. Ho, Stephen B. Baylin, Morris Muliaditan, Marcus Bantscheff, Elisabeth A. Minthorn, Thilo Werner, Alan P. Graves, Wendy A. Kellner, Phil Chapman, Mehul Patel, Anthony J. Jurewicz, Allan M. Jordan, Emma E. Fairweather, Rab K. Prinjha, Nino Campobasso, Anna Rutkowska, H. Christian Eberl, Ryan G. Kruger, Charles F. McHugh, Michael T. McCabe, Kristin M. Goldberg, Jon Paul Jaworski, Christopher L. Carpenter, Michael Steidel, Stuart Paul Romeril, Dirk A. Heerding, Lourdes Rueda, David T. Fosbenner, Amy N. Taylor, Jacques Briand, Shawn W. Foley, Arthur Groy, Andrew B. Benowitz, Xiaodong Cheng, Donald J. Ogilvie, Paola Grandi, Cunyu Zhang, Mei Li, Sarath Pathuri, Aidan G. Gilmartin, Christian S. Sherk, Juan I. Luengo, Mark Cockerill, Ali Raoof, Alexandra Stowell, Kathryn Keenan, Melissa B. Pappalardi, Makda Mebrahtu, Kristen Wong, Xing Zhang, Jessica L. Handler, Roger J. Butlin, John R. Horton, Susan Merrihew, Charlotte Burt, Dean E. McNulty
Publikováno v:
Nature Cancer. 2:1002-1017
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as the cytidine analogs decitabine or azacytidine, has demonstrated clinical ben
Autor:
Zachary Deuell, David Evans, Robert Stenberg, Robert Fuchs, Jordan Tozer, Michael J. Vitto, Jason Jennings, Christopher L Carpenter, Michael Joyce, Lindsay Taylor
Publikováno v:
Journal of Ultrasound in Medicine. 41:743-747
Objectives Thoracostomy is often a required treatment in patients with thoracic trauma; however, performing a thoracostomy using traditional techniques can have complications. Ultrasound can be a beneficial tool for identifying the correct thoracosto
Autor:
Douglas C. McLaughlin, Naren Subbiah, Timothy J. Lyford, Laurence A. Turka, Xuqing Zhang, Nicholas Bayhi, Shamael R. Dastagir, Mary Gribble, Ryan Pepi, Mengyao Luo, Viral Amin, Tiffany F. Chen, Christopher L. Moore, Annie Khamhoung, Christopher L. Carpenter, Mellissa J. Nixon, Albert Lee, Vikram Soman, Andrea Schmidt, Jennifer Mellen, Sneha Pawar, Thomas Joseph Wickham
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Checkpoint inhibitors and T-cell therapies have highlighted the critical role of T cells in anti-cancer immunity. However, limitations associated with these treatments drive the need for alternative approaches. Here, we engineer red blood cells into
Autor:
Shannon C. Leonard, Maegan Hoover, Thomas Wickham, Shannon McArdel, Sivan Elloul, Laurence A. Turka, Arjun Bollampalli, Zafira Castaño, Nicholas Bayhi, Christopher L. Carpenter, Enping Hong, Douglas C. McLaughlin, Kelvin Muriuki, Sneha Pawar, Jennifer Mellen, Anne-Sophie Dugast
Publikováno v:
Cancer Immunology, Immunotherapy
Recombinant agonists that activate co-stimulatory and cytokine receptors have shown limited clinical anticancer utility, potentially due to narrow therapeutic windows, the need for coordinated activation of co-stimulatory and cytokine pathways and th
Autor:
Geraldine Ferron-Brady, Naomi B. Haas, Sophie Cousin, Christopher L. Carpenter, Christopher A. French, Meg Annan, Victor Moreno, David S. Hong, Peter J. O'Dwyer, Anastasia Wyce, Rabinder K Prinjha, Nigel J. Parr, Irene Brana, Christine L. Hann, Arindam Dhar, Yuehui Wu, Sarina Anne Piha-Paul, P. A. Cassier, Olena Barbash, Johann S. de Bono, John Hilton, Thierry Horner, Sara Duckworth Harward, Mark C. Markowski, Geoffrey I. Shapiro
Publikováno v:
Scientia
JNCI Cancer Spectrum
JNCI Cancer Spectrum
Carcinoma; Concentració de fàrmac en plasma; Farmacocinètica Carcinoma; Concentración de fármaco en plasma; Farmacocinética Carcinoma; Plasma drug concentration; Pharmacokinetics Background Bromodomain and extra-terminal domain proteins are pro
Autor:
David W. Cescon, Timothy J. Pluard, Joseph A. Sparano, E Cunningham, Arindam Dhar, Christopher L. Carpenter, Elizabeth Tan-Chiu, Yuehui Wu, Mafalda Oliveira, Marc S. Ballas, Sy Oh
Publikováno v:
Cancer Research. 78:OT3-06
Background: Advanced or metastatic ER+BC (estrogen receptor positive breast cancer) is an incurable illness that will prove fatal for most afflicted women. Current standards of care include endocrine, targeted, and chemotherapy. Preclinical data sugg
Autor:
Satyajit R. Rajapurkar, Kelly Federowicz, Rab K. Prinjha, Ashley M. Hughes, Elizabeth Thomas, Natalie Karpinich, Ryan G. Kruger, Christopher L. Carpenter, Lodewyk F. A. Wessels, Melissa B. Pappalardi, James J. Foley, Kimberly N. Smitheman, Tesa M. Severson, Wendy S. Halsey, Helai P. Mohammad, Michael T. McCabe, Fredrick M. Mobegi, Christopher M. Traini, Jenny Laraio, Geraldine Ferron-Brady
Publikováno v:
Haematologica
Haematologica, 104(6)
Haematologica, 104(6)
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD