Výsledky vyhledávání - "Christopher L, Parks"

Akademický článek

Acute-phase innate immune responses in SIVmac239-infected Mamu-B*08+ Indian rhesus macaques may contribute to the establishment of elite control

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionSpontaneous control of chronic-phase HIV/SIV viremia is often associated with the expression of specific MHC class I allotypes. HIV/SIV-specific CD8+ cytotoxic T lymphocytes (CTLs) restricted by these MHC class I allotypes appear to be cr

Externí odkaz: https://doaj.org/article/a278c58415384153962a8239ac4c5dc6

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Akademický článek

Nonhuman Primates Are Protected against Marburg Virus Disease by Vaccination with a Vesicular Stomatitis Virus Vector-Based Vaccine Prepared under Conditions to Allow Advancement to Human Clinical Trials

Publikováno v: Vaccines, Vol 10, Iss 10, p 1582 (2022)

Vaccines are needed to disrupt or prevent continued outbreaks of filoviruses in humans across Western and Central Africa, including outbreaks of Marburg virus (MARV). As part of a filovirus vaccine product development plan, it is important to investi

Externí odkaz: https://doaj.org/article/78453db10ae14ff1a08f2abec5b5cb74

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Akademický článek

Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques

Autor: Nuria Pedreño-Lopez, Brandon C. Rosen, Walter J. Flores, Matthew J. Gorman, Thomas B. Voigt, Michael J. Ricciardi, Kristin Crosno, Kim L. Weisgrau, Christopher L. Parks, Jeffrey D. Lifson, Galit Alter, Eva G. Rakasz, Diogo M. Magnani, Mauricio A. Martins, David I. Watkins

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The antiviral properties of broadly neutralizing antibodies against HIV are well-documented but no vaccine is currently able to elicit protective titers of these responses in primates. While current vaccine modalities can readily induce non-neutraliz

Externí odkaz: https://doaj.org/article/953611f23bac4fb3b5b40dc083c6c0d6

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Akademický článek

Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques.

Publikováno v: PLoS Pathogens, Vol 13, Iss 7, p e1006529 (2017)

The ability to control lentivirus replication may be determined, in part, by the extent to which individual viral proteins are targeted by the immune system. Consequently, defining the antigens that elicit the most protective immune responses may fac

Externí odkaz: https://doaj.org/article/7f9298477dd24bad881bb9021f08cf80

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Akademický článek

A novel, live-attenuated vesicular stomatitis virus vector displaying conformationally intact, functional HIV-1 envelope trimers that elicits potent cellular and humoral responses in mice.

Autor: Svetlana Rabinovich, Rebecca L R Powell, Ross W B Lindsay, Maoli Yuan, Alexei Carpov, Aaron Wilson, Mary Lopez, John W Coleman, Denise Wagner, Palka Sharma, Marina Kemelman, Kevin J Wright, John P Seabrook, Heather Arendt, Jennifer Martinez, Joanne DeStefano, Maria J Chiuchiolo, Christopher L Parks

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106597 (2014)

Though vaccination with live-attenuated SIV provides the greatest protection from progressive disease caused by SIV challenge in rhesus macaques, attenuated HIV presents safety concerns as a vaccine; therefore, live viral vectors carrying HIV immunog

Externí odkaz: https://doaj.org/article/36bceef9cba94e478c80cf88e3a26f5c

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Akademický článek

Immunogenicity of seven new recombinant yellow fever viruses 17D expressing fragments of SIVmac239 Gag, Nef, and Vif in Indian rhesus macaques.

Autor: Mauricio A Martins, Myrna C Bonaldo, Richard A Rudersdorf, Shari M Piaskowski, Eva G Rakasz, Kim L Weisgrau, Jessica R Furlott, Christopher M Eernisse, Marlon G Veloso de Santana, Bertha Hidalgo, Thomas C Friedrich, Maria J Chiuchiolo, Christopher L Parks, Nancy A Wilson, David B Allison, Ricardo Galler, David I Watkins

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54434 (2013)

An effective vaccine remains the best solution to stop the spread of human immunodeficiency virus (HIV). Cellular immune responses have been repeatedly associated with control of viral replication and thus may be an important element of the immune re

Externí odkaz: https://doaj.org/article/3908158303ba449da6ffe4b5c5342ab9

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Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies

Autor: Joanne DeStefano, Aditya Arun Kumar, Aaron J. Wilson, Celia C. La Branche, Sanchari Bhattacharyya, Heather Arendt, David C. Montefiori, Mansi Purwar, Christopher L. Parks, Venkada Subramanian Vignesh, Raghavan Varadarajan, Raksha Das, Ujjwal Rathore

Publikováno v: Journal of Biological Chemistry. 293:15002-15020

Protein minimization is an attractive approach for designing vaccines against rapidly evolving pathogens such as human immunodeficiency virus, type 1 (HIV-1), because it can help in focusing the immune response toward conserved conformational epitope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ee69434387a68a3a3ea787a118be1e
https://doi.org/10.1074/jbc.ra118.005006

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