Výsledky vyhledávání - "Christopher Kohl"

Anticipating acceptance of emerging technologies using twitter: the case of self-driving cars

Autor: Galina Baader, Markus Böhm, Helmut Krcmar, Marlene Knigge, Christopher Kohl

Publikováno v: Journal of Business Economics. 88:617-642

In an early stage of developing emerging technologies, there is often great uncertainty regarding their future success. Companies can reduce this uncertainty by listening to the voice of customers as the customer eventually decides to accept an emerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ccb2bb46595714c9f248c232803733e
https://doi.org/10.1007/s11573-018-0897-5

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S1P1 Modulator-Induced Gαi Signaling and β-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo

Autor: Christopher Kohl, Markus Rey, Ruben de Kanter, Cyrille Lescop, Maxime Boucher, Magdalena Birker-Robaczewska, Oliver Nayler, Martin Bolli, Sylvie Poirey, Beat Steiner

Publikováno v: Molecular Pharmacology. 93:109-118

S1P1 (sphingosine-1-phosphate receptor 1) agonists prevent lymphocyte egress from secondary lymphoid organs and cause a reduction in the number of circulating blood lymphocytes. We hypothesized that S1P1 receptor modulators with pathway-selective sig

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https://doi.org/10.1124/mol.117.109140

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Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria

Autor: Thierry Bruyère, Eric A. Ertel, Stephanie Enderlin-Paput, Hans H. Locher, Michel Enderlin-Paput, Daniel Ritz, Christopher Kohl, Jean-Christophe Gauvin, Patrick Hess, Jean-Philippe Surivet, Azely Mirre, Daniel Bur, Cornelia Zumbrunn, Georg Rueedi, Christian Hubschwerlen, Peter Seiler

Publikováno v: Journal of Medicinal Chemistry. 60:3776-3794

There is an urgent unmet medical need for novel antibiotics that are effective against a broad range of bacterial species, especially multidrug resistant ones. Tetrahydropyran-based inhibitors of bacterial type II topoisomerases (DNA gyrase and topoi

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https://doi.org/10.1021/acs.jmedchem.6b01831

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Novel S1P 1 receptor agonists – Part 4: Alkylaminomethyl substituted aryl head groups

Autor: Thomas Weller, Martin Bolli, Claus Müller, Ruben de Kanter, Markus Rey, Magdalena Birker, Patrick Sieber, Cyrille Lescop, Christopher Kohl, Boris Mathys, Beat Steiner, Patrick Hess, Oliver Nayler

Publikováno v: European Journal of Medicinal Chemistry. 116:222-238

In a previous communication we reported on the discovery of alkylamino pyridine derivatives (e.g. 1) as a new class of potent, selective and efficacious S1P1 receptor (S1PR1) agonists. However, more detailed profiling revealed that this compound clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc8392021bea5d4bf4ef196324d4ad8
https://doi.org/10.1016/j.ejmech.2016.03.048

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Novel S1P1 receptor agonists – Part 5: From amino-to alkoxy-pyridines

Autor: Magdalena Birker, Jörg Velker, Patrick Hess, Ruben de Kanter, Oliver Nayler, Markus Rey, Beat Steiner, Martin Bolli, Patrick Sieber, Christopher Kohl, Cyrille Lescop, Thomas Weller

Publikováno v: European Journal of Medicinal Chemistry. 115:326-341

In a previous communication we reported on the discovery of aminopyridine 1 as a potent, selective and orally active S1P1 receptor agonist. More detailed studies revealed that this compound is phototoxic in vitro. As a result of efforts aiming at eli

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https://doi.org/10.1016/j.ejmech.2016.03.020

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In Vivo Pharmacodynamic Target Investigation of Two Bacterial Topoisomerase Inhibitors, ACT-387042 and ACT-292706, in the Neutropenic Murine Thigh Model against Streptococcus pneumoniae and Staphylococcus aureus

Autor: Daniel Ritz, David R. Andes, Jean-Philippe Surivet, Christopher Kohl, Alex Lepak, Peter Seiler

Publikováno v: Antimicrobial Agents and Chemotherapy. 60:3626-3632

ACT-387042 and ACT-292706 are two novel bacterial topoisomerase inhibitors with broad-spectrum activity against Gram-positive and -negative bacteria, including methicillin-resistant Staphylococcus aureus and penicillin- and fluoroquinolone-resistant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ac36ebf7d64568d3a7ea3f47ef795a
https://doi.org/10.1128/aac.00363-16

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Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug–Drug Interactions

Autor: Alexander Treiber, Stephan Buchmann, Jérôme Segrestaa, Stephane Delahaye, Christopher Kohl, Patricia N. Sidharta, Ruben de Kanter, Carmela Gnerre

Publikováno v: Clinical Pharmacokinetics. 55:369-380

Macitentan is a novel dual endothelin receptor antagonist for the treatment of pulmonary arterial hypertension (PAH). It is metabolized by cytochrome P450 (CYP) enzymes, mainly CYP3A4, to its active metabolite ACT-132577. A physiological-based pharma

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https://doi.org/10.1007/s40262-015-0322-y

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Using the Default Option Bias to Influence Decision Making While Driving

Autor: Jörg Preißinger, Michael Schermann, Christopher Kohl, Helmut Krcmar, Klaus Goffart

Publikováno v: International Journal of Human-Computer Interaction. 32:39-50

Gaining a better understanding of human–computer interaction in multiple-goal environments, such as driving, is critical as people increasingly use information technology to accomplish multiple tasks simultaneously. Extensive research shows that de

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https://doi.org/10.1080/10447318.2015.1085747

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